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NURS 642 EXAM

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This expertly curated guide for NURS 642 Exam 3 – Endocrine Section includes 100+ detailed questions and clinically supported answers, specially formatted for 2025/2026 nurse practitioner students. The content is designed for advanced nursing learners seeking mastery of endocrine pathology, including adrenal and thyroid disorders, with a strong emphasis on diagnostic workups, clinical presentations, medication management, and emergency interventions. Topics include hallmark clinical signs and treatment protocols for Addison’s disease, adrenal crisis, and adrenal insufficiency, including the cosyntropin stimulation test, 21-hydroxylase antibody detection, and hydrocortisone/fludrocortisone dosing. It also explores adrenal hemorrhage causes like Waterhouse-Friderichsen syndrome, and autoimmune polyendocrine syndromes. Thyroid disorders are covered extensively: Hashimoto’s thyroiditis, subacute thyroiditis, silent/postpartum thyroiditis, hypothyroidism complications (e.g., myxedema coma), and hyperthyroidism/Graves’ disease. Detailed treatment regimens are provided for thyroid storm, including methimazole, PPU, beta blockers, corticosteroids, and radioiodine therapy precautions. Imaging interpretation, risk factor stratification, and surgical complications are also discussed (e.g., vocal cord paralysis, hypoparathyroidism). Additional content includes Cushing’s syndrome pathophysiology, diagnostic testing (dexamethasone suppression test, ACTH levels, adrenal CT), and differential diagnosis for adrenal incidentalomas, pheochromocytomas, adrenocortical carcinoma, and metastases. Perfect for: AGNP, FNP, and ACNP students MSN/DNP candidates in endocrine, internal medicine, or acute care Courses in Advanced Pathophysiology, Pharmacology, and Diagnostic Reasoning AANP, ANCC, and other national board exam prep Keywords: adrenal crisis symptoms, cosyntropin test, Addison’s disease, ACTH levels, 21-hydroxylase antibody, adrenal hemorrhage, myxedema coma, thyroid storm treatment, methimazole dosing, Graves ophthalmopathy, hypothyroidism bradycardia, levothyroxine titration, subacute thyroiditis, Cushing’s syndrome workup, dexamethasone suppression, adrenal incidentaloma imaging, pheochromocytoma MRI, adrenal carcinoma CT, endocrine emergencies, NP endocrinology review

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NURS 642 Exam 3 Endocrine 2025/2026
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What are the signs and symptoms of adrenal crisis? - 🧠 ANSWER ✔✔The main

presenting problem is shock But there also may be other nonspecific symptoms

like nausea, vomiting, decreased appetite, abdominal pain, fatigue, fever,

confusion, weakness or lethargy


what are the precipitating factors for adrenal crisis ? - 🧠 ANSWER ✔✔-

Deficiencies in mineralocorticoids and glucocorticoids

- Acute stress or serious infection in patients with primary adrenal insufficiency

- Insufficient doses of glucocorticoid/mineralocorticoid in those with adrenal

insufficiency

- Acute destruction of adrenal gland secondary to hemorrhage of adrenal infarction

- Secondary cause due to abrupt cessation of glucocorticoid

,Common feature of primary adrenal insufficiency? - 🧠 ANSWER ✔✔Fatigue


Weight loss

N/V abdominal pain

Muscle and joint pain

Skin hyperpigmentation

Postural hypotension

Salt craving

Hyponatremia

Hyperkalemia

Anemia


Thyroiditis? - 🧠 ANSWER ✔✔-inflammation of the thyroid gland


-autoimmune (hashimoto's) most common

-high antithyroperoxidase or antithyroglobulin

-often progresses to hypothyroidism

- elevated ESR, leukocytosis, fever (infectious)

-middle age or older women


COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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, -common in hepatitis C

-dietary iodine supplements increase risk of developing

-lithium, amiodarone, thalidomide can trigger it

-painful subacute thyroiditis occurs after viral URI (low antithyroid antibodies,

painful large thyroid, dysphagia)

-low TSH and elevated T4

-US shows diffuse heterogenous density with reduced echogenicity

-low uptake with radioiodine (subacute)

-uneven or high uptake with radioiodine (hashimoto)


Hypothyroidism? - 🧠 ANSWER ✔✔*under activity of the thyroid gland


*causes:

-thyroid gland failure

-thyroid resection

-pituitary deficiency of TSH

-Hashimoto's is the most common cause

-medications



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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STATEMENT. ALL RIGHTS RESERVED

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