NU643 Comprehensive
Questions (Frequently Tested)
with Verified Answers Graded
A+
Amygdala - Answer: controls anxiety/fear/worry - anxiety d/o, phobias, PTSD, result from
malfunctions w/n these circuits. Flight or fight - motor response - PAG (periaqueductal gray)
located in brain stem
Locus Coeruleus - Answer: Home of noradrenergic cell bodies
Autonomic response
Inc BP, Inc HR, Inc RR,
- Prolonged activation = inc risk of atherosclerosis, MI, CAD, Stroke,
fear amygdala. - Answer: Motor response = brain stem(periaqueductal gray) - fight or flight
Endocrine response = hypothalamus
Fear conditioning - Answer: associate feat with neutral stimulus
VMPFC and hippocampus info passes to amygdala
Amygdala can remember stimuli w/ glutamate transmission
Glutamate - Answer: inhibitory stimuli
, conditioned-fear response - Answer: Memories do not get erased but can be rewired
Anxiety can be suppressed but IS NOT REMOVED ENTIRELY
Fear extinction - Answer: progressive reduction of response to stimuli to reduce symptoms
first-line treatment for GAD - Answer: SSRIs, SNRIs
d/t prolonged effectivness - BZ can be used for acute symptoms until effective
Buspar (serotonin) - Answer: 5HT1a affects - Post synaptincally - decreases 5HT activity-
Can help with relaxation - FDA for GAD
clonidine and propranolol - Answer: To tx physical response - decreased BP, HR - monitor VS for
safety
To reduce risk of falls, syncope issues when your BP or HR get low.
Typically used during the day...avoid at night to minimize risk of hypotension.
Avoid with eating DO as hydration can be an issue
Buspirone/anxiety D/O - Answer: GAD - indicated GAD
Used in other type in practice...but FDA indicated in
benzodiazepine GABA - Answer: Inhibitory - influx of Cl - decreases anxiety
SSRI/SNRI - Answer: Zoloft,
paxil, prozac - not mentioned in discussion but is also used for anxiety as well as MDD
Questions (Frequently Tested)
with Verified Answers Graded
A+
Amygdala - Answer: controls anxiety/fear/worry - anxiety d/o, phobias, PTSD, result from
malfunctions w/n these circuits. Flight or fight - motor response - PAG (periaqueductal gray)
located in brain stem
Locus Coeruleus - Answer: Home of noradrenergic cell bodies
Autonomic response
Inc BP, Inc HR, Inc RR,
- Prolonged activation = inc risk of atherosclerosis, MI, CAD, Stroke,
fear amygdala. - Answer: Motor response = brain stem(periaqueductal gray) - fight or flight
Endocrine response = hypothalamus
Fear conditioning - Answer: associate feat with neutral stimulus
VMPFC and hippocampus info passes to amygdala
Amygdala can remember stimuli w/ glutamate transmission
Glutamate - Answer: inhibitory stimuli
, conditioned-fear response - Answer: Memories do not get erased but can be rewired
Anxiety can be suppressed but IS NOT REMOVED ENTIRELY
Fear extinction - Answer: progressive reduction of response to stimuli to reduce symptoms
first-line treatment for GAD - Answer: SSRIs, SNRIs
d/t prolonged effectivness - BZ can be used for acute symptoms until effective
Buspar (serotonin) - Answer: 5HT1a affects - Post synaptincally - decreases 5HT activity-
Can help with relaxation - FDA for GAD
clonidine and propranolol - Answer: To tx physical response - decreased BP, HR - monitor VS for
safety
To reduce risk of falls, syncope issues when your BP or HR get low.
Typically used during the day...avoid at night to minimize risk of hypotension.
Avoid with eating DO as hydration can be an issue
Buspirone/anxiety D/O - Answer: GAD - indicated GAD
Used in other type in practice...but FDA indicated in
benzodiazepine GABA - Answer: Inhibitory - influx of Cl - decreases anxiety
SSRI/SNRI - Answer: Zoloft,
paxil, prozac - not mentioned in discussion but is also used for anxiety as well as MDD
