GMS 6552 Exam 2 with !| !| !| !| !|
accurate detailed solutions !| !|
Most common Drug Target
!| !| !|
Receptors
Time frame for Channel-linked Receptors
!| !| !| !|
Milliseconds
Class name for Channel-linked Receptors
!| !| !| !|
Ionotropic receptors!|
Example of Channel-linked Receptors
!| !| !|
Nicotinic/ACh Receptors !|
Time frame for GPCRs
!| !| !|
Seconds
Class name for GPCRs
!| !| !|
Metabotropic Receptors !|
Example of GPCRs
!| !|
Muscarinic/ACh Receptors !|
Time frame for Kinase-linked Receptors
!| !| !| !|
Minutes
Insulin receptors fall under which type of receptor category?
!| !| !| !| !| !| !| !|
Kinase-linked Receptors !|
,How long does it take for insulin to take effect?
!| !| !| !| !| !| !| !| !|
Minutes
Time frame of Nuclear receptors
!| !| !| !|
Hours to Days !| !|
How many transmembrane domains are there on GPCRs?
!| !| !| !| !| !| !|
7
The alpha subunit of G protein is what type of enzyme?
!| !| !| !| !| !| !| !| !| !|
GTPase (slow) !|
The G-proteins are [intracellular or extracellular]?
!| !| !| !| !|
intracellular, but membrane associated !| !| !|
The N-terminus of the GPCR is
!| !| !| !| !|
Extracellular
The C-terminus of the GPCR is
!| !| !| !| !|
Intracellular
When what is bound to alpha subunit, are the g proteins turned on?
!| !| !| !| !| !| !| !| !| !| !| !|
GTP
alpha S subunit of G protein activates
!| !| !| !| !| !|
adenylyl cyclase !|
Adenylyl cyclase increases !| !|
cAMP
cAMP activates !|
PKA
alpha I subunit of G proteins inhibits
!| !| !| !| !| !|
,Adenylyl cyclase !|
alpha q subunit of G protein activates
!| !| !| !| !| !|
PLC
PLC increases levels of what two things?
!| !| !| !| !| !|
DAG and IP3 !| !|
IP3 increases levels of intracellular _________
!| !| !| !| !|
Calcium
DAG activates !|
PKC
T/F: There are no 2nd messengers in Kinase-linked receptor signaling
!| !| !| !| !| !| !| !| !|
True
In receptors associated w/ cytosolic kinases:
!| !| !| !| !|
Receptors are initially _____________________ !| !| !|
once ligand binds, they _______________________
!| !| !| !|
After that, ________ gets activated which will phosphorylate
!| !| !| !| !| !| !| !|
__________ residues. !|
monomeric; dimerize; JAK; Tyrosine !| !| !|
In receptors associated w/ cytosolic kinases, proteins with _______
!| !| !| !| !| !| !| !| !|
domains (such as STAT, SHC, GRB2, PI3K) bind and gets activated via
!| !| !| !| !| !| !| !| !| !| !| !|
______________ of those residues. Once activated, they act as !| !| !| !| !| !| !| !| !|
__________________ and translocate to the ______________. !| !| !| !| !|
SH2; phosphorylation; Trxn factors; nucleus
!| !| !| !|
Receptor tyrosine kinases have ____________________ tyrosine
!| !| !| !| !| !|
kinase activity. !|
Intrinsic
, T/F: Insulin acts on receptor tyrosine kinases.
!| !| !| !| !| !|
True
The _____ subunits of receptor tyrosine kinases phosphorylate
!| !| !| !| !| !| !| !|
_________ residues. !|
beta; tyrosine !|
In receptor tyrosine kinases that have insulin bound, phosphorylated
!| !| !| !| !| !| !| !| !|
tyrosine residues will phosphorylate ________ which will activate
!| !| !| !| !| !| !| !|
______________ and the ___________ pathways. !| !| !| !|
IRS; GRB2/mSOS; PI3K
!| !|
The GRB2/mSOS pathway activates _____________.
!| !| !| !|
mek, MAPK, etc. !| !|
The PI3K pathway activates _____________ pathway which
!| !| !| !| !| !| !|
phosphorylates effector proteins. !| !|
PKB/AKT
In receptor Ser/Thr kinases, ligands bind to type _____ receptor which
!| !| !| !| !| !| !| !| !| !| !|
will then ___________ with the type ___ receptor.
!| !| !| !| !| !| !|
2; dimerize; 1
!| !|
Once receptor Ser/Thr Kinases are activated, the type ____ receptor
!| !| !| !| !| !| !| !| !| !|
will phosphorylate the type ____ receptor.
!| !| !| !| !|
2; 1 !|
Once the type 1 receptor is phosphorylated on Ser/Thr kinase receptors,
!| !| !| !| !| !| !| !| !| !| !|
it will phosphorylate which type of proteins?
!| !| !| !| !| !|
SMADs or Receptor Activated SMADs or R-SMADs
!| !| !| !| !| !|
SMADs will then act as _________ which translocate to the nucleus
!| !| !| !| !| !| !| !| !| !|
Trxn Factors !|
accurate detailed solutions !| !|
Most common Drug Target
!| !| !|
Receptors
Time frame for Channel-linked Receptors
!| !| !| !|
Milliseconds
Class name for Channel-linked Receptors
!| !| !| !|
Ionotropic receptors!|
Example of Channel-linked Receptors
!| !| !|
Nicotinic/ACh Receptors !|
Time frame for GPCRs
!| !| !|
Seconds
Class name for GPCRs
!| !| !|
Metabotropic Receptors !|
Example of GPCRs
!| !|
Muscarinic/ACh Receptors !|
Time frame for Kinase-linked Receptors
!| !| !| !|
Minutes
Insulin receptors fall under which type of receptor category?
!| !| !| !| !| !| !| !|
Kinase-linked Receptors !|
,How long does it take for insulin to take effect?
!| !| !| !| !| !| !| !| !|
Minutes
Time frame of Nuclear receptors
!| !| !| !|
Hours to Days !| !|
How many transmembrane domains are there on GPCRs?
!| !| !| !| !| !| !|
7
The alpha subunit of G protein is what type of enzyme?
!| !| !| !| !| !| !| !| !| !|
GTPase (slow) !|
The G-proteins are [intracellular or extracellular]?
!| !| !| !| !|
intracellular, but membrane associated !| !| !|
The N-terminus of the GPCR is
!| !| !| !| !|
Extracellular
The C-terminus of the GPCR is
!| !| !| !| !|
Intracellular
When what is bound to alpha subunit, are the g proteins turned on?
!| !| !| !| !| !| !| !| !| !| !| !|
GTP
alpha S subunit of G protein activates
!| !| !| !| !| !|
adenylyl cyclase !|
Adenylyl cyclase increases !| !|
cAMP
cAMP activates !|
PKA
alpha I subunit of G proteins inhibits
!| !| !| !| !| !|
,Adenylyl cyclase !|
alpha q subunit of G protein activates
!| !| !| !| !| !|
PLC
PLC increases levels of what two things?
!| !| !| !| !| !|
DAG and IP3 !| !|
IP3 increases levels of intracellular _________
!| !| !| !| !|
Calcium
DAG activates !|
PKC
T/F: There are no 2nd messengers in Kinase-linked receptor signaling
!| !| !| !| !| !| !| !| !|
True
In receptors associated w/ cytosolic kinases:
!| !| !| !| !|
Receptors are initially _____________________ !| !| !|
once ligand binds, they _______________________
!| !| !| !|
After that, ________ gets activated which will phosphorylate
!| !| !| !| !| !| !| !|
__________ residues. !|
monomeric; dimerize; JAK; Tyrosine !| !| !|
In receptors associated w/ cytosolic kinases, proteins with _______
!| !| !| !| !| !| !| !| !|
domains (such as STAT, SHC, GRB2, PI3K) bind and gets activated via
!| !| !| !| !| !| !| !| !| !| !| !|
______________ of those residues. Once activated, they act as !| !| !| !| !| !| !| !| !|
__________________ and translocate to the ______________. !| !| !| !| !|
SH2; phosphorylation; Trxn factors; nucleus
!| !| !| !|
Receptor tyrosine kinases have ____________________ tyrosine
!| !| !| !| !| !|
kinase activity. !|
Intrinsic
, T/F: Insulin acts on receptor tyrosine kinases.
!| !| !| !| !| !|
True
The _____ subunits of receptor tyrosine kinases phosphorylate
!| !| !| !| !| !| !| !|
_________ residues. !|
beta; tyrosine !|
In receptor tyrosine kinases that have insulin bound, phosphorylated
!| !| !| !| !| !| !| !| !|
tyrosine residues will phosphorylate ________ which will activate
!| !| !| !| !| !| !| !|
______________ and the ___________ pathways. !| !| !| !|
IRS; GRB2/mSOS; PI3K
!| !|
The GRB2/mSOS pathway activates _____________.
!| !| !| !|
mek, MAPK, etc. !| !|
The PI3K pathway activates _____________ pathway which
!| !| !| !| !| !| !|
phosphorylates effector proteins. !| !|
PKB/AKT
In receptor Ser/Thr kinases, ligands bind to type _____ receptor which
!| !| !| !| !| !| !| !| !| !| !|
will then ___________ with the type ___ receptor.
!| !| !| !| !| !| !|
2; dimerize; 1
!| !|
Once receptor Ser/Thr Kinases are activated, the type ____ receptor
!| !| !| !| !| !| !| !| !| !|
will phosphorylate the type ____ receptor.
!| !| !| !| !|
2; 1 !|
Once the type 1 receptor is phosphorylated on Ser/Thr kinase receptors,
!| !| !| !| !| !| !| !| !| !| !|
it will phosphorylate which type of proteins?
!| !| !| !| !| !|
SMADs or Receptor Activated SMADs or R-SMADs
!| !| !| !| !| !|
SMADs will then act as _________ which translocate to the nucleus
!| !| !| !| !| !| !| !| !| !|
Trxn Factors !|
