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GMS 6552 Exam with accurate detailed solutions

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Exam (elaborations)

GMS 6552 Exam with accurate detailed solutions

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18 pages

2024/2025

Institution GMS 6552

Course GMS 6552

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GMS 6552 Exam with accurate detailed solutions

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GMS 6552 Exam with !| !| !| !|

accurate detailed !| !|

solutions

What is the most common molecular drug target?
!| !| !| !| !| !| !| !|

Enzymes

Hormones & Factors !| !|

Receptors

Ion Channels
!|

DNA - Correct answer ✔Receptors
!| !| !| !|

Channel-linked (ionotropic) receptor time scale - Correct answer
!| !| !| !| !| !| !| !|

✔Milliseconds

G-protein coupled receptor time scale - Correct answer ✔Seconds
!| !| !| !| !| !| !| !|

Kinase-linked receptor time scale - Correct answer ✔Minutes
!| !| !| !| !| !| !|

Nuclear receptor time scale - Correct answer ✔Hours
!| !| !| !| !| !| !|

,Number of GPCR receptors - Correct answer ✔>800
!| !| !| !| !| !| !|

GPCR Ligands - Correct answer ✔Hormones, neurotransmitters,
!| !| !| !| !| !| !|

chemokine, ions, amino acids, peptides !| !| !| !|

G alpha proteins - Correct answer ✔20
!| !| !| !| !| !|

G beta proteins - Correct answer ✔6
!| !| !| !| !| !|

G gamma proteins - Correct answer ✔12
!| !| !| !| !| !|

Why use G proteins? - Correct answer ✔Amplify signal, regulate more
!| !| !| !| !| !| !| !| !| !| !|

than one effector
!| !|

signal transduction cascade of cyclic AMP - Correct answer ✔Adrenaline
!| !| !| !| !| !| !| !| !| !|

binds to adrenergic receptor --> alpha GTP activates adenylyl cyclase -->
!| !| !| !| !| !| !| !| !| !| !|

ATP converted to cAMP --> PKA is activated --> transcription changes
!| !| !| !| !| !| !| !| !| !|

What proteins does PKA phosphorylate - Correct answer
!| !| !| !| !| !| !| !|

✔phosphorylase kinase, L-type Ca channels, pyruvate kinase, CREB, !| !| !| !| !| !| !| !|

hormone sensitive lipase !| !|

Phospholipase C activation activates - Correct answer ✔DAG, IP3
!| !| !| !| !| !| !| !|

, Kinase linked receptor signaling - Correct answer ✔hormone binds -->
!| !| !| !| !| !| !| !| !| !|

change in kinase and/or phosphatase activity
!| !| !| !| !|

Protein kinase linked receptors - Correct answer ✔cytosolic kinases,
!| !| !| !| !| !| !| !| !|

tyrosine kinases, serine/threonine kinases
!| !| !|

Cytosolic kinases - Correct answer ✔Ligand binds --> receptors dimerize
!| !| !| !| !| !| !| !| !| !|

--> JAK activated --> STAT activated --> dimerization and nuclear
!| !| !| !| !| !| !| !| !| !|

translocation

Receptor tyrosine kinases - Correct answer ✔an extracellular ligand
!| !| !| !| !| !| !| !| !|

binding and dimerization domain, a single hydrophobic transmembrane
!| !| !| !| !| !| !| !|

alpha helix and a cytosolic domain with intrinsic tyrosine kinase activity
!| !| !| !| !| !| !| !| !| !|

Types of receptor tyrosine kinases - Correct answer ✔single
!| !| !| !| !| !| !| !| !|

transmembrane spanning proteins that dimerize when ligand binds or !| !| !| !| !| !| !| !| !|

covalently linked dimers !| !|

PKB/Akt proteins effects - Correct answer ✔Glycogen synthesis, protein
!| !| !| !| !| !| !| !| !|

synthesis, glycolysis, glucose transport, transcription of specific gene
!| !| !| !| !| !| !|

Serine/threonine receptor kinases - Correct answer ✔ligand binds to !| !| !| !| !| !| !| !| !|

type 2 receptor, type 2 receptor dimerizes type 1 receptor, type 1
!| !| !| !| !| !| !| !| !| !| !| !|

receptor activates SMAD 2, Smad 2 binds to smad 4
!| !| !| !| !| !| !| !| !|

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Uploaded on: July 25, 2025
Number of pages: 18
Written in: 2024/2025
Type: Exam (elaborations)
Contains: Questions & answers

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