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GMS 6552 Exam with verified detailed solutions

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Exam (elaborations)

GMS 6552 Exam with verified detailed solutions

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27 pages

2024/2025

Institution GMS 6552

Course GMS 6552

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GMS 6552 Exam with verified detailed solutions

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GMS 6552 Exam with !| !| !| !|

verified detailed !| !|

solutions

Most common drug target - Correct answer ✔- receptors
!| !| !| !| !| !| !| !|

Channel-linked receptors - Correct answer ✔- ion channels open when
!| !| !| !| !| !| !| !| !| !|

bound to ligand !| !|

- hyperpolarization or depolarization
!| !| !|

- milliseconds
!|

- ex. nicotinic receptor, ACh receptor
!| !| !| !| !|

G-protein coupled receptors - Correct answer ✔- use second messenger
!| !| !| !| !| !| !| !| !| !|

systems to induce cellular effects when bound
!| !| !| !| !| !|

- seconds
!|

- ex. muscarinic ACh receptor
!| !| !| !|

Kinase-linked receptors - Correct answer ✔- cause protein
!| !| !| !| !| !| !| !|

phosphorylation inducing cellular effects when bound !| !| !| !| !|

-minutes

,- ex. insulin receptor
!| !| !|

Nuclear receptors - Correct answer ✔- induce gene transcription when
!| !| !| !| !| !| !| !| !| !|

bound

- hours
!|

- ex. estrogen receptor
!| !| !|

Heterotrimeric G proteins - Correct answer ✔- receptor
!| !| !| !| !| !| !|

- alpha, beta, gamma - subunits
!| !| !| !| !|

- amplify signal
!| !|

- induce second messenger systems
!| !| !| !|

Alpha subunit - Correct answer ✔- binds GTP converting to GDP
!| !| !| !| !| !| !| !| !| !|

GPCR ligands - Correct answer ✔- hormones
!| !| !| !| !| !|

- neurotransmitters
!|

- chemokines
!|

- ions
!|

- amino acids
!| !|

- peptides
!|

- etc.
!|

PKA - Correct answer ✔- protein kinase A
!| !| !| !| !| !| !|

, - activated by cyclic AMP
!| !| !| !|

- enter nucleus and alter transcription
!| !| !| !| !|

Phosphorylase kinase - Correct answer ✔- activated by PKA
!| !| !| !| !| !| !| !|

- breakdown glycogen
!| !|

L-type Ca Channels - Correct answer ✔- activated by PKA
!| !| !| !| !| !| !| !| !|

- heart contraction
!| !|

Pyruvated kinase - Correct answer ✔- activated by PKA
!| !| !| !| !| !| !| !|

- activate gylcolysis
!| !|

Hormone sensitve lipase - Correct answer ✔- activated by PKA
!| !| !| !| !| !| !| !| !|

- cause triglyceride breakdown
!| !| !|

CREB - Correct answer ✔- activated by PKA
!| !| !| !| !| !| !|

- cause gene transcription
!| !| !|

Adenylate cyclase - Correct answer ✔- activated by GPCR
!| !| !| !| !| !| !| !|

- cAMP as second messenger
!| !| !| !|

- activate PKA
!| !|

Phosphollipase C - Correct answer ✔- activated by GPCR !| !| !| !| !| !| !| !|

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Uploaded on: July 25, 2025
Number of pages: 27
Written in: 2024/2025
Type: Exam (elaborations)
Contains: Questions & answers

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