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*Dosing for low dose colchicine - Correct Answer-✔✔1.2 mg followed by 0.6 one
hour later or 1.8 mg total
*Dosing for high dose colchicine - Correct Answer-✔✔1.2 mg followed by 0.6 mg
every 4 to 6 hours; or 4.8 mg total.
What is the difference between low dosing and high dosing of colchicine - Correct
Answer-✔✔low dose is as effective as high dose with lower side effect profile
What medication is used for gout? - Correct Answer-✔✔Colchicine
What does colchicine do? - Correct Answer-✔✔Used for gout and to treat and
prevent gout attacks. Also Behcets syndrome.
Sid effects of Cochicine - Correct Answer-✔✔Always Diarrhea. Upset Stomach,
nausea, abdominal pain.
Instructions for colchicine - Correct Answer-✔✔take with food to help decrease GI
side effects
,What should be checked with colchicine? - Correct Answer-✔✔Renal Function
before and during treatment. (BUN, Creatinine)
Patient Education for Colchicine - Correct Answer-✔✔Always causes severe
degree of diarrhea so make sure that people understand that.
Mr. Holloway presents to your clinic with a significantly swollen, painful big toe
and you diagnose him with gout. Of the following options which would be the
best treatment for Mr. Holloway?
a. Acetaminophen with codeine
b. Low-dose colchicine
c. High-dose colchicine
d. High-dose aspirin - Correct Answer-✔✔Low-dose colchicine. Low-dose
colchicine is 1.2 mg followed by 0.6 mg one hour later or 1.8 mg total. High-dose
colchicine is 1.2 mg followed by 0.6 mg Q4 to Q6 hours or 4.8 mg total. The
difference between the two is low-dose is as effective as high-dose with a lower
side effect profile.
Patient education when prescribing colchicine includes?
a. Moderate amounts of alcohol are safe with colchicine
b. Colchicine may be constipating
c. Colchicine always causes some degree of diarrhea
d. Mild muscle weakness is normal - Correct Answer-✔✔B. Colchicine always
causes some degree of diarrhea
,What lab value should be monitored with gout? - Correct Answer-✔✔Check renal
function test, BUN, Creatine
Cholchesine - Correct Answer-✔✔for gout, think about alcohol
Allopurinol is used for what? - Correct Answer-✔✔Gout
MOA Allopurinol - Correct Answer-✔✔xanthine oxidase inhibitor. uric acid
reducer, prevents flare ups and kidney stones
SE of Allopurinol - Correct Answer-✔✔skin rash, flu like symptoms, painful or little
urination, drowsi, dizzy
Monitor what with Allopurinol - Correct Answer-✔✔BUN, Creatinine, Liver
Function
You have a patient who is taking allopurinol to prevent gout. What labs will you
monitor for this patient on allopurinol?
a. Blood glucose
b. Complete blood count
c. BUN, creatinine, and creatinine clearance
d. C-reactive protein - Correct Answer-✔✔BUN, creatinine, and creatinine
clearance
, Patient teaching for Uloric - Correct Answer-✔✔Gout may worsen with therapy
initially
Uloric other medication - Correct Answer-✔✔Febuxostat
Febuxostat (Uloric) MOA - Correct Answer-✔✔xanthine oxidase inhibitor, uric acid
reducer for its with gout and prevent flares.
SE of Febuxostat (Uloric) - Correct Answer-✔✔gout flares, nausea, mild rash, liver
problems, heart attack symptoms
Febuxostat (Uloric) need to monitor what? - Correct Answer-✔✔liver and renal
function
Patient education for Uloric - Correct Answer-✔✔Got may worsen with therapy
initially
What medication can you take with Uloric? - Correct Answer-✔✔NSAID or
colchicine for up to 6 months w/ beginning of treatment for gouty flare ups
Mr. Thompson has just started taking febuxostat (Uloric) to treat his gout and he
needs to be educated on what to expect.
a. Feuxostat may cause severe diarrhea
b. He will need frequent CBC monitoring
c. He should consume a high-calcium diet