7/22/25, 9:48 AM Rush - Advanced Pharmacology - NSG 531 - Exam 1 (2025 updated) QUESTIONS AND ANSWERS (DETAILED & ELABORATED)…
Rush - Advanced Pharmacology - NSG 531 -
Exam 1 (2025 updated) QUESTIONS AND
ANSWERS (DETAILED & ELABORATED) fully
solved
Save
Terms in this set (131)
a substance intended for use in the diagnosis, cure,
mitigation, treatment, or prevention of disease and a
Drug
substance, other than food, intended to affect the
structure or any function of the body
T/F most drugs are strong F - most drugs are weak acids or weak bases
acids or strong bases
1. absorbs it
2. distributes it (think about it - most drugs don't have
what are the four things
MOA in the stomach or GI tract, the body distributes
that the body does to a
to where it acts)
drug?
3. biotransforms or metabolizes it
4. eliminates it
Pharmacokinetics what the body does to the drug
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 1/25
,7/22/25, 9:48 AM Rush - Advanced Pharmacology - NSG 531 - Exam 1 (2025 updated) QUESTIONS AND ANSWERS (DETAILED & ELABORATED)…
drugs that are given orally have to get out of the gut
and into circulation
in order to do that the drugs have to pass through cell
membranes
Describe absorption this means there has to be some form of solubility for
the drug to pass through the cell membrane
cell membranes are made of lipids
therefore drugs have to have some form of lipid
solubility
What are cell membranes phsopholipid bilayer
made of?
What is the only route of IV push - because it goes directly into circulation
drug that does not have to
pass through the cell
membrane?
What are the four 1. simple diffusion
mechanisms of transport 2. channel-mediated
across the cell 3. carrier-mediated
membrane? 4. Active Transport
-drug has to be lipid soluble
-there has to be a concentration gradient present
Simple diffusion - what
-if a drug is high in fat solubility it is not going to be
has to be true?
very water soluble - these two properties balance
each other out
If a drug is high in lipid it may meet an aqueous solution and because it is not
solubility and it is able to highly water soluble it will need to bind to a carrier
be transported by simple protein to be transported throughout the circulation
diffusion, what will happen
once it crosses the cell
membrane?
What are the channels in channels are two groups of proteins on each side that
Channel mediated create a pore in the cell membrane
transport
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 2/25
, 7/22/25, 9:48 AM Rush - Advanced Pharmacology - NSG 531 - Exam 1 (2025 updated) QUESTIONS AND ANSWERS (DETAILED & ELABORATED)…
there are two groups of proteins on each side that
create a pore in the cell membrane
how does channel
there is water within the pore/channel that the water
mediated transport work?
soluble drug can go through and the protein walls of
the channel create a barrier from the lipid bilayer
-there is a carrier protein embedded in the surface of
the cell membrane that fits the drug that is trying to
pass
-you have to have a complementary fit between the
protein and the drug
How does carrier
-if it fits then it binds causing a conformation change
mediated transport work?
-the orientation of the protein flips over so that the
open side of the protein is now on the opposite side
and the drug is transported to the other side of the
cell membrane
-again a concentration gradient is needed
a change in how something is oriented
i.e. carrier-mediated transport where the protein
conformational change accepts the drug, then flips, orienting the open side
of the protein to the opposite side of the cell
membrane
what are the three types simple diffusion, channel-mediated, carrier-mediated
of passive transport
Does a lipid soluble or lipid soluble
water soluble drug get
absorbed more quickly?
-whether the drug is an acid or a base
what does solubility of a
-the pH of the environment in which the drug is
drug depend on?
located
hydrogen ion concentration
what does pH measure?
pH = -log (H+)
what happens when you it gives up its' hydrogen ion and releases it into
put an acidic drug in solution
solution?
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 3/25
Rush - Advanced Pharmacology - NSG 531 -
Exam 1 (2025 updated) QUESTIONS AND
ANSWERS (DETAILED & ELABORATED) fully
solved
Save
Terms in this set (131)
a substance intended for use in the diagnosis, cure,
mitigation, treatment, or prevention of disease and a
Drug
substance, other than food, intended to affect the
structure or any function of the body
T/F most drugs are strong F - most drugs are weak acids or weak bases
acids or strong bases
1. absorbs it
2. distributes it (think about it - most drugs don't have
what are the four things
MOA in the stomach or GI tract, the body distributes
that the body does to a
to where it acts)
drug?
3. biotransforms or metabolizes it
4. eliminates it
Pharmacokinetics what the body does to the drug
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 1/25
,7/22/25, 9:48 AM Rush - Advanced Pharmacology - NSG 531 - Exam 1 (2025 updated) QUESTIONS AND ANSWERS (DETAILED & ELABORATED)…
drugs that are given orally have to get out of the gut
and into circulation
in order to do that the drugs have to pass through cell
membranes
Describe absorption this means there has to be some form of solubility for
the drug to pass through the cell membrane
cell membranes are made of lipids
therefore drugs have to have some form of lipid
solubility
What are cell membranes phsopholipid bilayer
made of?
What is the only route of IV push - because it goes directly into circulation
drug that does not have to
pass through the cell
membrane?
What are the four 1. simple diffusion
mechanisms of transport 2. channel-mediated
across the cell 3. carrier-mediated
membrane? 4. Active Transport
-drug has to be lipid soluble
-there has to be a concentration gradient present
Simple diffusion - what
-if a drug is high in fat solubility it is not going to be
has to be true?
very water soluble - these two properties balance
each other out
If a drug is high in lipid it may meet an aqueous solution and because it is not
solubility and it is able to highly water soluble it will need to bind to a carrier
be transported by simple protein to be transported throughout the circulation
diffusion, what will happen
once it crosses the cell
membrane?
What are the channels in channels are two groups of proteins on each side that
Channel mediated create a pore in the cell membrane
transport
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 2/25
, 7/22/25, 9:48 AM Rush - Advanced Pharmacology - NSG 531 - Exam 1 (2025 updated) QUESTIONS AND ANSWERS (DETAILED & ELABORATED)…
there are two groups of proteins on each side that
create a pore in the cell membrane
how does channel
there is water within the pore/channel that the water
mediated transport work?
soluble drug can go through and the protein walls of
the channel create a barrier from the lipid bilayer
-there is a carrier protein embedded in the surface of
the cell membrane that fits the drug that is trying to
pass
-you have to have a complementary fit between the
protein and the drug
How does carrier
-if it fits then it binds causing a conformation change
mediated transport work?
-the orientation of the protein flips over so that the
open side of the protein is now on the opposite side
and the drug is transported to the other side of the
cell membrane
-again a concentration gradient is needed
a change in how something is oriented
i.e. carrier-mediated transport where the protein
conformational change accepts the drug, then flips, orienting the open side
of the protein to the opposite side of the cell
membrane
what are the three types simple diffusion, channel-mediated, carrier-mediated
of passive transport
Does a lipid soluble or lipid soluble
water soluble drug get
absorbed more quickly?
-whether the drug is an acid or a base
what does solubility of a
-the pH of the environment in which the drug is
drug depend on?
located
hydrogen ion concentration
what does pH measure?
pH = -log (H+)
what happens when you it gives up its' hydrogen ion and releases it into
put an acidic drug in solution
solution?
https://quizlet.com/1061586217/rush-advanced-pharmacology-nsg-531-exam-1-2025-updated-questions-and-answers-detailed-elaborated-fully-solve… 3/25
