GCU NUR 635 midterm Questions and Answers
Pharmacokinetics includes - Correct Answer - absorption, distribution, metabolism,
elimination
absorption of drugs factors - Correct Answer - PH changes, gastric emptying, gastric
enzymes, bile acids, GI flora, food and nutrient interactions, lipid solubility
Where is cyp450 system found - Correct Answer - endoplasmic reticulum of hepatocytes
CYP3A4/5 - Correct Answer - most abundant CYP450 isoform which metabolizes the most
prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin.
CYP2D6 - Correct Answer - metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active
CYP2c8/9 - Correct Answer - warfarin
CYP1A2 - Correct Answer - AcetAminophen
CRAP GPS induces my rage - Correct Answer - carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas
, rectal admin has what absorption - Correct Answer - variable and erratic
steady state (SS) is usually reached within how many half-lives of a drug - Correct Answer -
4-5
zero-order(nonlinear) pharmacokinetics means a drug is metabolized - Correct Answer - at
a constant rate per unit time
Michaelis-menten pharmacokinetics - Correct Answer - the rate of drug elimination is
directly proportion to the concentration of free drug (phenytoin)
theraputic index - Correct Answer - TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index
Agonist - Correct Answer - drugs that alter the physiology of a cell by binding to plasma
membrane or intracellular receptors
Antagonists (drugs) - Correct Answer - These drugs block the actions caused by agonists
off-label use - Correct Answer - a drug can be used for an unapproved indication and is
legitimate if there is clinical data supporting its use for that indication
"safe" drug means - Correct Answer - the FDA has determined the drugs benefits are
greater than the possible risks involved with its use
elimination of drugs most often involves what function - Correct Answer - renal
Beta Blockers - Correct Answer - -olol
Pharmacokinetics includes - Correct Answer - absorption, distribution, metabolism,
elimination
absorption of drugs factors - Correct Answer - PH changes, gastric emptying, gastric
enzymes, bile acids, GI flora, food and nutrient interactions, lipid solubility
Where is cyp450 system found - Correct Answer - endoplasmic reticulum of hepatocytes
CYP3A4/5 - Correct Answer - most abundant CYP450 isoform which metabolizes the most
prescribed
" "drugs. Especially important for bioavailability due to its abundance in
" "cells lining the GI tract. Can be induced by a wide variety of drugs "
"and is potently inhibited by ketoconazole and erythromycin.
CYP2D6 - Correct Answer - metabolizes 25% of prescribed drugs
*3*4*5 majority of bad metabolizers
Antidepressants
Antipsychotics
Antiarrythmics
*carvedilol, *metoprolol
*codeine → morphine
*tamoxifen to active
CYP2c8/9 - Correct Answer - warfarin
CYP1A2 - Correct Answer - AcetAminophen
CRAP GPS induces my rage - Correct Answer - carbamazepine, rifampin,
alcohol, phenytoin, griseofulun, phenobarbitone, sulfonylureas
, rectal admin has what absorption - Correct Answer - variable and erratic
steady state (SS) is usually reached within how many half-lives of a drug - Correct Answer -
4-5
zero-order(nonlinear) pharmacokinetics means a drug is metabolized - Correct Answer - at
a constant rate per unit time
Michaelis-menten pharmacokinetics - Correct Answer - the rate of drug elimination is
directly proportion to the concentration of free drug (phenytoin)
theraputic index - Correct Answer - TD50 = median toxic dose
ED50 = median effective dose
window = between those doses
safe drugs have a wider or high window/index
Agonist - Correct Answer - drugs that alter the physiology of a cell by binding to plasma
membrane or intracellular receptors
Antagonists (drugs) - Correct Answer - These drugs block the actions caused by agonists
off-label use - Correct Answer - a drug can be used for an unapproved indication and is
legitimate if there is clinical data supporting its use for that indication
"safe" drug means - Correct Answer - the FDA has determined the drugs benefits are
greater than the possible risks involved with its use
elimination of drugs most often involves what function - Correct Answer - renal
Beta Blockers - Correct Answer - -olol
