GMS 6401 MOCK EXAM 2025
QUESTIONS AND ANSWERS
The kidney consists of specialized vascular and tubular structures (the nephron) which
collaborate in the production of urine: - ANS The glomerular capillary is surrounded by an
epithelial structure which forms the beginning of the tubule.
A diagnostic renal clearance experiment is conducted and the following steady state (=
equilibrium) measurements are obtained on a 34 year old male subject, weighing 60 kg (assume
that the renal plasma flow (RPF) is the same as the effective renal plasma flow (ERPF):
Urine inulin = 200 mg/100ml
Plasma inulin = 4 mg/100ml
Urine flow (V) = 2ml/min
Urine PAH = 1200 mg/100ml
Plasma PAH = 6 mg/100ml - ANS GFR = 100ml/min
Any substance which is freely filtered at the glomerulus, is reabsorbed and is not secreted, will
have a renal clearance that is: Choose one best answer. - ANS Less than the clearance of
inulin
An increased protein excretion (proteinuria) can indicate glomerular damage. Which of the
following changes are likely to cause proteinuria? Choose 1 best answer: - ANS Loss of
nephrin from the epithelial slit pore diaphragm
Maintenance of a high glomerular filtration rate (GFR) is required for optimal kidney function.
Which of the following options would be most likely to associate with a below optimal GFR in
man? - ANS A low glomerular capillary water permeability
1 Copyright ©2025 FYNDLAY ALL RIGHTS RESERVED.
QUESTIONS AND ANSWERS
The kidney consists of specialized vascular and tubular structures (the nephron) which
collaborate in the production of urine: - ANS The glomerular capillary is surrounded by an
epithelial structure which forms the beginning of the tubule.
A diagnostic renal clearance experiment is conducted and the following steady state (=
equilibrium) measurements are obtained on a 34 year old male subject, weighing 60 kg (assume
that the renal plasma flow (RPF) is the same as the effective renal plasma flow (ERPF):
Urine inulin = 200 mg/100ml
Plasma inulin = 4 mg/100ml
Urine flow (V) = 2ml/min
Urine PAH = 1200 mg/100ml
Plasma PAH = 6 mg/100ml - ANS GFR = 100ml/min
Any substance which is freely filtered at the glomerulus, is reabsorbed and is not secreted, will
have a renal clearance that is: Choose one best answer. - ANS Less than the clearance of
inulin
An increased protein excretion (proteinuria) can indicate glomerular damage. Which of the
following changes are likely to cause proteinuria? Choose 1 best answer: - ANS Loss of
nephrin from the epithelial slit pore diaphragm
Maintenance of a high glomerular filtration rate (GFR) is required for optimal kidney function.
Which of the following options would be most likely to associate with a below optimal GFR in
man? - ANS A low glomerular capillary water permeability
1 Copyright ©2025 FYNDLAY ALL RIGHTS RESERVED.
