ASCP Hematology Review – Complete Exam Preparation with Questions and Answers (U.S. Certification)

Name the locations of active marrow in adults: ~CORRECT
ANSWER~✓✓sternum, skull, ribs, pelvis, vertebrae



Where does hematopoiesis take place during the first 2 months of gestation?
~CORRECT ANSWER~✓✓yolk sac



Where does the majority of hematopoiesis take place during the 2nd through 7th
month of gestation? ~CORRECT ANSWER~✓✓spleen



When does the bone marrow take over hematopoiesis? ~CORRECT
ANSWER~✓✓after birth



What are the stages in order of the erythrocyte lineage? ~CORRECT
ANSWER~✓✓(1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte,
(5)reticulocyte, (6)erytrocyte



What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil)
lineage? ~CORRECT ANSWER~✓✓(1)myeloblast, (2)promyelocyte,
(3)myelocyte, (4)metamyelocyte, (5)band, (6)segmented (7)eos/baso



What are the stages in order of the macrophage lineage? ~CORRECT
ANSWER~✓✓(1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage

,What are the stages in order of the platelet lineage? ~CORRECT
ANSWER~✓✓(1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte,
(4)platelet



What are the stages in order of the lymphocyte lineage? ~CORRECT
ANSWER~✓✓(1)lymphoblast, (2)prolymphocyte, (3)lymphocyte



Which growth factors stimulate the erythrocyte lineage? ~CORRECT
ANSWER~✓✓GM-CSF, EPO, IL-3



Which growth factors stimulate the granulocyte lineages? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3



Which growth factors stimulate the platelet lineage? ~CORRECT
ANSWER~✓✓GM-CSF, IL-3, TPO



Which growth factors stimulate the lymphocyte lineage? ~CORRECT
ANSWER~✓✓IL-2, IL-4, IL-6, IL-7



Which protein functions in the transport of Fe? ~CORRECT
ANSWER~✓✓transferrin



What is the major storage form of Fe? ~CORRECT ANSWER~✓✓ferritin

,What is the long-term (H20) insoluble Fe storage form called? ~CORRECT
ANSWER~✓✓hemosiderin



Excess Iron is stored where? What does this cause? ~CORRECT
ANSWER~✓✓tissues and body organs, hemosiderosis, hemochromatosis



Porphyrias are attributed to? ~CORRECT ANSWER~✓✓excessive formation of
porphrins due to blockages in any enzymatic step in the heme synthesis
pathway.



Red or port wine colored urine can be seen in which condition related to the
build up of heme precursors? ~CORRECT ANSWER~✓✓porphyria



Neuropsychiatirc symptoms are seen when a build up of which precursors
occurs? ~CORRECT ANSWER~✓✓early precursors (Delta-aminolevulinic
acid/Porphobilinogen)



Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a
build up of which precursors occurs? ~CORRECT ANSWER~✓✓later precursors
(uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)



Synthesis of heme requires what two components? ~CORRECT
ANSWER~✓✓iron, protoporphyrin

, What are the heme precursors in order of synthesis? ~CORRECT
ANSWER~✓✓(1)delta-aminolevulinic acid, (2)porphobilinogen,
(3)uroporphyrinogen, (4)coproporphyrinogen, (5)protoporphyrin, (6)heme



What type of hemoglobin is seen primarily in newborns? ~CORRECT
ANSWER~✓✓Hgb F



What type of hemoglobin is seen primarily in adults? ~CORRECT
ANSWER~✓✓Hgb A2



What type of hemoglobin is rarely seen in adults as well as newborns?
~CORRECT ANSWER~✓✓Hgb A



What hemoglobin types are seen in embryos but not in adults or newborns?
~CORRECT ANSWER~✓✓gower I, gower II, portland



All non-embryonic hemoglobin types are comprised of what type of globin
chain? ~CORRECT ANSWER~✓✓alpha



Hemoglobin A2 is composed of what types of globin chains? ~CORRECT
ANSWER~✓✓alpha, beta



Hemoglobin A is composed of what types of globin chains? ~CORRECT
ANSWER~✓✓alpha, delta