BIOC 384 Exam 3 | 123 Questions And Correct
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New Update 2025
what might lead to a positive regulatory mechanism? - ANSWER -An increase
in enzyme activity caused by an increase in enzyme synthesis
-An enhancement of catalytic efficiency caused by conformation changes in the
enzyme active site
What are the two mechanisms in which enzyme regulation is mediate by? -
ANSWER -Bioavailability, how much of that enzyme is present in tissues and
cell compartments
-Catalytic efficiency through protein modification- covalent and non-covalent
bonds
RNA synthesis, RNA processing, Protein Synthesis, Protein Targeting, and Protein
Degradation are all processes that control what mechanism of enzyme regulation?
- ANSWER Enzyme Bioavailability
Binding of regulatory molecules, covalent modification, and proteolytic processing
all contribute to what mechanism of enzyme regulation? - ANSWER Catalytic
Efficiency
The difference between reversible and irreversible enzyme inhibition comes down
to what? - ANSWER The type of interaction with catalytic groups at the active
site (covalent vs noncovalent)
,How can we distinguish a reversible inhibitor from an irreversible inhibitor? -
ANSWER By dilution. A diluted reversible will have decreased effect, while an
irreversible will still partake in activity.
What is the effect on fumarate production when malonate levels are high? -
ANSWER Fumarate production decreases
Dehydration of succinate leads to formation of what product? - ANSWER
Fumarate (citric acid cycle intermediate)
a1-antitrypsin is an example of what? - ANSWER An irreversible inhibitor
how does diisopropylflourophosphate work to act as an irreversible inhibitor on
elastase proteases? - ANSWER By using its phosphate to bond with serine
residues
what is a pharmaceutical benefit of reversible inhibitors? - ANSWER no drug
withdrawal
What defines a competitive inhibitor? - ANSWER That it binds to the active
site or alters the active site ability to bind to a substrate
Increasing concentration of an inhibitor increases the ____ and need for substrate
concentration to reach ____ - ANSWER K(m) and V(max)
, Indinavir and Saquinavir interrupt the HIV lifecycle how? - ANSWER By being
competitive inhibitors to an aspartate protease enzyme in HIV, which is vital to
maturation of HIV
Excess end product of a metabolic pathway acting as an inhibitor of the first
enzyme in the pathway is a simple example of ______ ______ - ANSWER
Feedback Inhibition
What acts as feedback inhibition for ATCase? - ANSWER ATP and CTP (the
product of the pyrimidine pathway)
High levels of ATP in the pyrimidine pathway will do what to ATCase? -
ANSWER It will increase ATCase because high ATP levels signify high energy in
the cell available to synthesize DNA (via ATCase)
What are homotropic allosteric activators? - ANSWER Substrates that bind to
an active site which increase affinity for binding of the same type of substrate to
other sites on the enzyme
Carbomyl phosphate and aspartate bind to the active site of what? - ANSWER
Aspartate tricarbomylate (ATCase)
Where do ATP and CTP bind on ATC ase? - ANSWER The regulatory subunit, as
opposed to the catalytic subunit w/ the active site
When ATP is bound to ATCase regulatory subunit, what happens? - ANSWER
ATCase goes into the relaxed state, which is the active state and that forms CTP
Answers (Verified Answers) | Already Graded A+ |
New Update 2025
what might lead to a positive regulatory mechanism? - ANSWER -An increase
in enzyme activity caused by an increase in enzyme synthesis
-An enhancement of catalytic efficiency caused by conformation changes in the
enzyme active site
What are the two mechanisms in which enzyme regulation is mediate by? -
ANSWER -Bioavailability, how much of that enzyme is present in tissues and
cell compartments
-Catalytic efficiency through protein modification- covalent and non-covalent
bonds
RNA synthesis, RNA processing, Protein Synthesis, Protein Targeting, and Protein
Degradation are all processes that control what mechanism of enzyme regulation?
- ANSWER Enzyme Bioavailability
Binding of regulatory molecules, covalent modification, and proteolytic processing
all contribute to what mechanism of enzyme regulation? - ANSWER Catalytic
Efficiency
The difference between reversible and irreversible enzyme inhibition comes down
to what? - ANSWER The type of interaction with catalytic groups at the active
site (covalent vs noncovalent)
,How can we distinguish a reversible inhibitor from an irreversible inhibitor? -
ANSWER By dilution. A diluted reversible will have decreased effect, while an
irreversible will still partake in activity.
What is the effect on fumarate production when malonate levels are high? -
ANSWER Fumarate production decreases
Dehydration of succinate leads to formation of what product? - ANSWER
Fumarate (citric acid cycle intermediate)
a1-antitrypsin is an example of what? - ANSWER An irreversible inhibitor
how does diisopropylflourophosphate work to act as an irreversible inhibitor on
elastase proteases? - ANSWER By using its phosphate to bond with serine
residues
what is a pharmaceutical benefit of reversible inhibitors? - ANSWER no drug
withdrawal
What defines a competitive inhibitor? - ANSWER That it binds to the active
site or alters the active site ability to bind to a substrate
Increasing concentration of an inhibitor increases the ____ and need for substrate
concentration to reach ____ - ANSWER K(m) and V(max)
, Indinavir and Saquinavir interrupt the HIV lifecycle how? - ANSWER By being
competitive inhibitors to an aspartate protease enzyme in HIV, which is vital to
maturation of HIV
Excess end product of a metabolic pathway acting as an inhibitor of the first
enzyme in the pathway is a simple example of ______ ______ - ANSWER
Feedback Inhibition
What acts as feedback inhibition for ATCase? - ANSWER ATP and CTP (the
product of the pyrimidine pathway)
High levels of ATP in the pyrimidine pathway will do what to ATCase? -
ANSWER It will increase ATCase because high ATP levels signify high energy in
the cell available to synthesize DNA (via ATCase)
What are homotropic allosteric activators? - ANSWER Substrates that bind to
an active site which increase affinity for binding of the same type of substrate to
other sites on the enzyme
Carbomyl phosphate and aspartate bind to the active site of what? - ANSWER
Aspartate tricarbomylate (ATCase)
Where do ATP and CTP bind on ATC ase? - ANSWER The regulatory subunit, as
opposed to the catalytic subunit w/ the active site
When ATP is bound to ATCase regulatory subunit, what happens? - ANSWER
ATCase goes into the relaxed state, which is the active state and that forms CTP
