Nanomedicine Exam 3 Questions with Detailed
Verified Answers (100% Correct Answers) Already
Graded A+
Quiz: NPs can enhance the therapeutic effects of certain drugs by, Ans: -
increasing circulation time
-increasing stability/compatibility
-promoting cellular internalization
-targeted delivery
Quiz: NPs can enhance medical diagnosis by, Ans: -improving detection limit
of target molecules or cells
-reduce the amt of sample needed
-faster
-less invasive methods
Quiz: How can nanomedicine improve surgery?, Ans: 1) direct
-hemostatic NPs promote healing
-nanocoating surgical blades
2) indirect
-prevent post-surgical complications
Quiz: Hemostatic agents, Ans: substances to help prevent/stop bleeding
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,Quiz: blunt trauma, Ans: any kind of physical trauma that occurs by impact,
injury or violence
Quiz: blast trauma, Ans: any kind of physical trauma that occurs from a
direct or indirect exposure to an explosion
Quiz: blunt/blast trauma cause internal bleeding; why is this so bad, Ans: -
blood loss after traumatic injury leading cause of death
-can bleed out quickly
-early intervention to halt bleeding can help patient get to hospital
Quiz: Hemostatic NPs name & structure, Ans: GRGDS-NPs
structure:
-core: polymer PLGA attached to poly-e-lysine= (PLGA-PLL)
-tails: PEG
-on end of tails: peptide sequence RGB
-size abt 400nm
Quiz: 2 common ways to prepare PLGAs, Ans: 1) single emulsion: PLGA &
hydrophobic drug in nonpolar organic solvent added to aqueous stabilizer
solution
2)double emulsion: PLGA solution added to aqueous hydrophilic drug solution
subject to heat and after first emulsion it is poured in aqueous stabilizer
solution as second emulsion
© 2025 Get it right Stuvia US All rights reserved
, Quiz: Blast trauma animal model, Ans: 1) induce injury ((1)apply weight over
certain distance or (2) preform laparotomy)
2) animal die
3) NP (GRGDS-NPs) administered to animals
Quiz: How do the hemostatic NPs work (GRGS-NPs), Ans: enhance the
aggregation of platelets to stop bleeding
-GRGDS-NPs (hemostatic NPs) promote platelet aggregation by binding to the
glycoprotein 2b/3a receptors on the surface of platelets to stabilize the whole
clot
Quiz: How does clotting work, Ans: -clotting is the process by which blood
changes from a liquid to a gel
-platelets: special type of blood cell that clumps after blood vessel injury;
activation results in release of prothrombotic molecules
-platelet aggregation: also trigger the coagulation cascade and formation of
thrombin
-fibrinogen: fibrous protein
after cut/injury the glycoprotein will bind to collagen, glycoprotein recognizes
the exposed von Willebrand factor which activates platelets, platelets change
from spherical to dendritic shape, activation of platelets trigger formation of
clot (introduction of fibrinogen), platelets interact with glycoprotein receptors
and attach to fibrinogen to tangle up with glycoproteins to form the clot
© 2025 Get it right Stuvia US All rights reserved
Verified Answers (100% Correct Answers) Already
Graded A+
Quiz: NPs can enhance the therapeutic effects of certain drugs by, Ans: -
increasing circulation time
-increasing stability/compatibility
-promoting cellular internalization
-targeted delivery
Quiz: NPs can enhance medical diagnosis by, Ans: -improving detection limit
of target molecules or cells
-reduce the amt of sample needed
-faster
-less invasive methods
Quiz: How can nanomedicine improve surgery?, Ans: 1) direct
-hemostatic NPs promote healing
-nanocoating surgical blades
2) indirect
-prevent post-surgical complications
Quiz: Hemostatic agents, Ans: substances to help prevent/stop bleeding
© 2025 Get it right Stuvia US All rights reserved
,Quiz: blunt trauma, Ans: any kind of physical trauma that occurs by impact,
injury or violence
Quiz: blast trauma, Ans: any kind of physical trauma that occurs from a
direct or indirect exposure to an explosion
Quiz: blunt/blast trauma cause internal bleeding; why is this so bad, Ans: -
blood loss after traumatic injury leading cause of death
-can bleed out quickly
-early intervention to halt bleeding can help patient get to hospital
Quiz: Hemostatic NPs name & structure, Ans: GRGDS-NPs
structure:
-core: polymer PLGA attached to poly-e-lysine= (PLGA-PLL)
-tails: PEG
-on end of tails: peptide sequence RGB
-size abt 400nm
Quiz: 2 common ways to prepare PLGAs, Ans: 1) single emulsion: PLGA &
hydrophobic drug in nonpolar organic solvent added to aqueous stabilizer
solution
2)double emulsion: PLGA solution added to aqueous hydrophilic drug solution
subject to heat and after first emulsion it is poured in aqueous stabilizer
solution as second emulsion
© 2025 Get it right Stuvia US All rights reserved
, Quiz: Blast trauma animal model, Ans: 1) induce injury ((1)apply weight over
certain distance or (2) preform laparotomy)
2) animal die
3) NP (GRGDS-NPs) administered to animals
Quiz: How do the hemostatic NPs work (GRGS-NPs), Ans: enhance the
aggregation of platelets to stop bleeding
-GRGDS-NPs (hemostatic NPs) promote platelet aggregation by binding to the
glycoprotein 2b/3a receptors on the surface of platelets to stabilize the whole
clot
Quiz: How does clotting work, Ans: -clotting is the process by which blood
changes from a liquid to a gel
-platelets: special type of blood cell that clumps after blood vessel injury;
activation results in release of prothrombotic molecules
-platelet aggregation: also trigger the coagulation cascade and formation of
thrombin
-fibrinogen: fibrous protein
after cut/injury the glycoprotein will bind to collagen, glycoprotein recognizes
the exposed von Willebrand factor which activates platelets, platelets change
from spherical to dendritic shape, activation of platelets trigger formation of
clot (introduction of fibrinogen), platelets interact with glycoprotein receptors
and attach to fibrinogen to tangle up with glycoproteins to form the clot
© 2025 Get it right Stuvia US All rights reserved
