UNE Medical Biochemistry Midterm Exam
Questions With Correct Answers
Which |of |the |following |proteins |is |likely |to |have |quaternary |structure? |- |CORRECT |
ANSWER✔✔-A |multimeric |protein |that |contains |multiple |peptide |chains
Prosthetic |groups |are |complex |nonprotein |molecules |that |participate |in |catalysis |by |providing |
functional |groups |that |form |a |covalent |intermediate |between |the |enzyme |and |the |substrate. |
Which |of |the |following |is |an |example |of |a |coenzyme |or |cofactor |that |participates |in |a |covalent
|catalysis |reaction? |- |CORRECT |ANSWER✔✔-Pyridoxal |phosphate
Which |of |the |following |best |describes |a |protein |domain? |- |CORRECT |ANSWER✔✔-A |section |of
|a |protein |structure |sufficient |to |perform |a |particular |chemical |or |physical |task
Cleavage |of |fructose |1,6 |bisphosphate |to |dihydroxyacetone |and |Glyceraldehyde |3-phosphate |
involves |the |breaking |of |a |carbon-carbon |bond |through |a |process |other |than |oxidation |or |
hydrolysis. |This |is |achieved |by |what |class |of |enzymes? |- |CORRECT |ANSWER✔✔-Lyase
A |55-year |old |man |is |brought |to |the |emergency |room |with |a |chief |complaint |of |chest |pain |and
|tingling |in |his |left |arm. |Elevation |of |which |of |the |following |enzymes |in |circulation |would |be |
most |indicative |of |myocardial |infarction? |- |CORRECT |ANSWER✔✔-Troponin
Allosteric |activators |of |hemoglobin |will |increase |substrate |binding |through |which |of |the |
following |mechanisms? |- |CORRECT |ANSWER✔✔-Binding |the |protein, |and |keeping |it |in |the |"R" |
conformation
Which |of |the |following |best |describes |tertiary |structure? |- |CORRECT |ANSWER✔✔-Interactions |
between |alpha |helices |and |beta |sheets |to |form |a |domain
, How |do |most |enzymes |reduce |the |activation |energy |needed |to |move |a |reaction |forward? |- |
CORRECT |ANSWER✔✔-providing |an |active |site |most |complementary |to |the |transition |state
Domains |are |common |structural |elements |that |retain |a |particular |function |within |the |protein. |
Which |of |the |following |is |an |example |of |a |protein |domain? |- |CORRECT |ANSWER✔✔-An |
arrangement |of |beta-strands |connected |by |alpha-helices |(beta-alpha-beta-alpha)
Which |amino |acid |would |not |be |commonly |found |in |the |middle |of |an |alpha-helical |domain? |- |
CORRECT |ANSWER✔✔-Proline
Which |of |the |following |is |a |true |statement |with |regards |to |the |malate-aspartate |shuttle |
system? |- |CORRECT |ANSWER✔✔-Generates |2.5 |molecules |of |ATP |in |mitochondria |per |each |
NADH |from |glycolysis.
Complex |II |(Succinate |Q-reductase) |is |not |considered |part |of |the |process |of |oxidative |
phosphorylation |because |it |is |unable |to |do |which |of |the |following |activities? |- |CORRECT |
ANSWER✔✔-Pump |protons |from |the |mitochondrial |matrix |into |the |inter |membrane |space.
Succinate |is |a |substrate |for |which |complex |in |the |electron |transport |chain? |- |CORRECT |
ANSWER✔✔-Complex |II |(Succinate-Q |reductase)
The |glycerophosphate |shuttle |is |the |major |shuttle |of |most |tissues. |Which |of |the |following |best
|describes |the |transfer |of |electrons |by |this |shuttle? |- |CORRECT |ANSWER✔✔-Electrons |are |
directly |transferred |from |glycerol |3-phosphate |to |an |FAD |containing |glycerol |phosphate |
dehydrogenase.
A |19-year |old |male |is |being |evaluated |for |muscle |weakness. |Evaluation |of |a |muscle |biopsy |
revealed |normal |rates |of |succinate |oxidation |but |very |low |rates |of |pyruvate |oxidation. |Further |
testing |determined |normal |levels |of |enzymatic |activity |in |both |malate |dehydrogenase |and |
pyruvate |dehydrogenase. |Based |on |this |data, |the |patient |may |have |a |mutation |in |a |gene |
encoding |for |which |mitochondrial |protein? |- |CORRECT |ANSWER✔✔-Complex |I |(NADH |Q-
oxidoreductase)
Questions With Correct Answers
Which |of |the |following |proteins |is |likely |to |have |quaternary |structure? |- |CORRECT |
ANSWER✔✔-A |multimeric |protein |that |contains |multiple |peptide |chains
Prosthetic |groups |are |complex |nonprotein |molecules |that |participate |in |catalysis |by |providing |
functional |groups |that |form |a |covalent |intermediate |between |the |enzyme |and |the |substrate. |
Which |of |the |following |is |an |example |of |a |coenzyme |or |cofactor |that |participates |in |a |covalent
|catalysis |reaction? |- |CORRECT |ANSWER✔✔-Pyridoxal |phosphate
Which |of |the |following |best |describes |a |protein |domain? |- |CORRECT |ANSWER✔✔-A |section |of
|a |protein |structure |sufficient |to |perform |a |particular |chemical |or |physical |task
Cleavage |of |fructose |1,6 |bisphosphate |to |dihydroxyacetone |and |Glyceraldehyde |3-phosphate |
involves |the |breaking |of |a |carbon-carbon |bond |through |a |process |other |than |oxidation |or |
hydrolysis. |This |is |achieved |by |what |class |of |enzymes? |- |CORRECT |ANSWER✔✔-Lyase
A |55-year |old |man |is |brought |to |the |emergency |room |with |a |chief |complaint |of |chest |pain |and
|tingling |in |his |left |arm. |Elevation |of |which |of |the |following |enzymes |in |circulation |would |be |
most |indicative |of |myocardial |infarction? |- |CORRECT |ANSWER✔✔-Troponin
Allosteric |activators |of |hemoglobin |will |increase |substrate |binding |through |which |of |the |
following |mechanisms? |- |CORRECT |ANSWER✔✔-Binding |the |protein, |and |keeping |it |in |the |"R" |
conformation
Which |of |the |following |best |describes |tertiary |structure? |- |CORRECT |ANSWER✔✔-Interactions |
between |alpha |helices |and |beta |sheets |to |form |a |domain
, How |do |most |enzymes |reduce |the |activation |energy |needed |to |move |a |reaction |forward? |- |
CORRECT |ANSWER✔✔-providing |an |active |site |most |complementary |to |the |transition |state
Domains |are |common |structural |elements |that |retain |a |particular |function |within |the |protein. |
Which |of |the |following |is |an |example |of |a |protein |domain? |- |CORRECT |ANSWER✔✔-An |
arrangement |of |beta-strands |connected |by |alpha-helices |(beta-alpha-beta-alpha)
Which |amino |acid |would |not |be |commonly |found |in |the |middle |of |an |alpha-helical |domain? |- |
CORRECT |ANSWER✔✔-Proline
Which |of |the |following |is |a |true |statement |with |regards |to |the |malate-aspartate |shuttle |
system? |- |CORRECT |ANSWER✔✔-Generates |2.5 |molecules |of |ATP |in |mitochondria |per |each |
NADH |from |glycolysis.
Complex |II |(Succinate |Q-reductase) |is |not |considered |part |of |the |process |of |oxidative |
phosphorylation |because |it |is |unable |to |do |which |of |the |following |activities? |- |CORRECT |
ANSWER✔✔-Pump |protons |from |the |mitochondrial |matrix |into |the |inter |membrane |space.
Succinate |is |a |substrate |for |which |complex |in |the |electron |transport |chain? |- |CORRECT |
ANSWER✔✔-Complex |II |(Succinate-Q |reductase)
The |glycerophosphate |shuttle |is |the |major |shuttle |of |most |tissues. |Which |of |the |following |best
|describes |the |transfer |of |electrons |by |this |shuttle? |- |CORRECT |ANSWER✔✔-Electrons |are |
directly |transferred |from |glycerol |3-phosphate |to |an |FAD |containing |glycerol |phosphate |
dehydrogenase.
A |19-year |old |male |is |being |evaluated |for |muscle |weakness. |Evaluation |of |a |muscle |biopsy |
revealed |normal |rates |of |succinate |oxidation |but |very |low |rates |of |pyruvate |oxidation. |Further |
testing |determined |normal |levels |of |enzymatic |activity |in |both |malate |dehydrogenase |and |
pyruvate |dehydrogenase. |Based |on |this |data, |the |patient |may |have |a |mutation |in |a |gene |
encoding |for |which |mitochondrial |protein? |- |CORRECT |ANSWER✔✔-Complex |I |(NADH |Q-
oxidoreductase)
