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1.The 1/2 life of lithium is about?:ANS 24 hours
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2.Fluoxetine is the SSRI with the f f f f f f WD risk?: ANS lowest due to long hal
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f life
3.What antipsychotics are good for pts who miss doses of their meds?: ANS
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f An- tipsychotics with long half-lives:
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1.Cariprazine(Vrylar): (2-4 days-active metabolites up to 3 weeks) f f f f f f f
2.Abilify (3 days) f f
3.Brexipiprazole (4 days) f f
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,4.Pimozide (4-5 days) f f
5.Pimavanserin (2 days, active metabolites 8 days) f f f f f f
4.Disulfiram's alcohol interactions persist for up to how long after the med-
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f ication is stopped?: ANS LONG Half life--2-3 days
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persist up to 2 weeks following stopping
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5.What is the only TCA with a long half life?: ANS Protriptyline (Vivactil)
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6.Most psychotropics have a medium range 1/2 life of approx?: ANS 24 hours
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7.what does "steady state" mean in relation to 1/2 life?: ANS steady state means
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f that you are eliminating the drug at the same overall rate that you are
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f ingesting it f
8.Lithium reaches its 'steady state' when?: ANS 5 half lives
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example:
Day 1: Start pt on Lithium 600 mg daily
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Day 2: (24 hours later) the amount left in his body is 300 mg (day 2 min)
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f because 24 hours has passed--one 1/2 life--therefore the pt has excreted
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,f 1/2 of the initial amount.
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THEN the pt takes his 2nd dose of 600 mg on DAY 2-resulting in a max dose of
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f 900 (300 mg left in body + 600 mg of 2nd dose).
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DAY 3: starts off with 450 mg (1/2 of the 900 mg in pt's system) and after taking
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f the day 3 600 mg dose, the pt now has a total of 1050 mg.
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9.Due to the steady state of Lithium, when do we draw a blood level?: ANS 5
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f half lives f
if you check any earlier, the trough level will underestimate the actual level th
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f pt is on after achieving steady state
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10.Fluoxetine has a half life of about?: ANS 2 weeks 1/2 life f f f f f f f f f f f
take 2.5 months to achieve steady state
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11.Most psychotropic medications operate in this fashion:: ANS "when you
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f double the dose, the serum dose doubles." f f f f f f
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, *minus three SRIs and three anticonvulsants (Fluoxetine, fluvoxamine, paxil
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f gabapentin, valproate and carbamazepine) f f f
12. induces it's own metabolism, hastening excretion and shorten-
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f ing it's half life: ANS A. Carbamazepine (Tegretol)
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*this effect begins to "rev up" after 2-4 weeks--which is why a
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f carbamazepine level is so important on obtaining 1-2 months after starting
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f Tegretol.
13.Carbamazepine (Tegretol) level should be checked how soon after starting to
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f take this med?: ANS 1-2 months due to Tegretol inducing it's own
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f metabolism, hastening excretion and shortening it's half life.
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14. has trouble getting a "serum" level because it binds to proteins that
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f render it therapeutically inactive?: ANS A. Valproate Acid (Depakote)
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-this is particularly true at the lower levels (eg. <50 mcg/mL), so you can
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