1|Page
UNE (UNIVERSITY OF NEW ENGLAND) MEDICAL BIOCHEMISTRY
FINAL EXAM (2 LATEST VERSIONS) LATEST 2025 ACTUAL EXAM
WITH COMPLETE QUESTIONS AND CORRECT DETAILED ANSWERS
(100% VERIFIED ANSWERS) |ALREADY GRADED A+| ||PROFESSOR
VERIFIED|| ||BRANDNEW!!!||
VERSION A
Which of the following is the regulatory enzyme in cholesterol
synthesis?
HMG-CoA synthase
HMG-CoA reductase
Acetyl CoA carboxylase
Carnitine palmitoyl transferase I (CPTI) - ANSWER-HMG-CoA
reductase
Ketogenesis is regulated by the rate of several other processes.
Which of the following would decrease the rate of ketone body
synthesis?
Increased flux through the TCA cycle.
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Increased β-oxidation
Increased lipolysis
Increased transport of FFA across the mitochondrial membrane -
ANSWER-Increased flux through the TCA cycle.
A 3-year-old male is brought to the emergency department by his
parents. He is unconscious on admittance and his blood glucose
was 15 mg/dl, ( normal 75 - 105 mg/dl). Further testing showed
this individual had a deficiency in carnitine. Based on this
diagnosis you would also expect which of the following to be true
with regards to metabolism:
This patient would have decreased levels of lipolysis.
This patient would have increased ketogenesis.
This patient would have elevated levels of circulating free fatty
acids.
This patient would have increased activity of gluconeogenesis. -
ANSWER-This patient would have elevated levels of circulating
free fatty acids.
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An individual goes to bed around 8 pm and doesn't wake up until
9 am the next morning. During this time, which of the following is
the primary oxidizable substrate for skeletal muscle?
Free fatty acids
Lactate
Glycogen
Amino acids - ANSWER-Free fatty acids
In the liver, which of the following key inhibitory events ensures
that newly synthesized palmitoyl-CoA is not immediately
oxidized?
Carnitine acylcarnitine translocase (CAT) by palmitoyl-CoA
Carnitine palmitoyl transferase-I (CPTI) by palmitoylcarnitine
Acyl-CoA synthetase by malonyl CoA
Carnitine palmitoyl transferase-II (CPTII) by acetyl-CoA
Carnitine palmitoyl transferase-I (CPTI) by malonyl-CoA -
ANSWER-Carnitine palmitoyl transferase-I (CPTI) by malonyl-
CoA
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A 3 day-old male is brought to the emergency department by
ambulance. He is unconscious on admission. Laboratory analysis
of a blood sample shows hypoglycemia and no ketones. Blood
spot analysis showed elevation of medium chain acylcarnitines as
hexanoyl carnitine (C6), octanoyl carnitine (C8). A urine sample
was positive for dicarboxylic acids. This clinical picture is most
consistent with a defect in the:
α-oxidation of very long chain fatty acids
β-oxidation of medium chain fatty acids
Carnitine transporter for long chain fatty acids
ω-oxidation of short chain fatty acids - ANSWER-β-oxidation of
medium chain fatty acids
Which of the following is the regulatory enzyme for fatty acid
synthesis?
Acetyl-CoA carboxylase
Citrate lyase
UNE (UNIVERSITY OF NEW ENGLAND) MEDICAL BIOCHEMISTRY
FINAL EXAM (2 LATEST VERSIONS) LATEST 2025 ACTUAL EXAM
WITH COMPLETE QUESTIONS AND CORRECT DETAILED ANSWERS
(100% VERIFIED ANSWERS) |ALREADY GRADED A+| ||PROFESSOR
VERIFIED|| ||BRANDNEW!!!||
VERSION A
Which of the following is the regulatory enzyme in cholesterol
synthesis?
HMG-CoA synthase
HMG-CoA reductase
Acetyl CoA carboxylase
Carnitine palmitoyl transferase I (CPTI) - ANSWER-HMG-CoA
reductase
Ketogenesis is regulated by the rate of several other processes.
Which of the following would decrease the rate of ketone body
synthesis?
Increased flux through the TCA cycle.
,2|Page
Increased β-oxidation
Increased lipolysis
Increased transport of FFA across the mitochondrial membrane -
ANSWER-Increased flux through the TCA cycle.
A 3-year-old male is brought to the emergency department by his
parents. He is unconscious on admittance and his blood glucose
was 15 mg/dl, ( normal 75 - 105 mg/dl). Further testing showed
this individual had a deficiency in carnitine. Based on this
diagnosis you would also expect which of the following to be true
with regards to metabolism:
This patient would have decreased levels of lipolysis.
This patient would have increased ketogenesis.
This patient would have elevated levels of circulating free fatty
acids.
This patient would have increased activity of gluconeogenesis. -
ANSWER-This patient would have elevated levels of circulating
free fatty acids.
,3|Page
An individual goes to bed around 8 pm and doesn't wake up until
9 am the next morning. During this time, which of the following is
the primary oxidizable substrate for skeletal muscle?
Free fatty acids
Lactate
Glycogen
Amino acids - ANSWER-Free fatty acids
In the liver, which of the following key inhibitory events ensures
that newly synthesized palmitoyl-CoA is not immediately
oxidized?
Carnitine acylcarnitine translocase (CAT) by palmitoyl-CoA
Carnitine palmitoyl transferase-I (CPTI) by palmitoylcarnitine
Acyl-CoA synthetase by malonyl CoA
Carnitine palmitoyl transferase-II (CPTII) by acetyl-CoA
Carnitine palmitoyl transferase-I (CPTI) by malonyl-CoA -
ANSWER-Carnitine palmitoyl transferase-I (CPTI) by malonyl-
CoA
, 4|Page
A 3 day-old male is brought to the emergency department by
ambulance. He is unconscious on admission. Laboratory analysis
of a blood sample shows hypoglycemia and no ketones. Blood
spot analysis showed elevation of medium chain acylcarnitines as
hexanoyl carnitine (C6), octanoyl carnitine (C8). A urine sample
was positive for dicarboxylic acids. This clinical picture is most
consistent with a defect in the:
α-oxidation of very long chain fatty acids
β-oxidation of medium chain fatty acids
Carnitine transporter for long chain fatty acids
ω-oxidation of short chain fatty acids - ANSWER-β-oxidation of
medium chain fatty acids
Which of the following is the regulatory enzyme for fatty acid
synthesis?
Acetyl-CoA carboxylase
Citrate lyase
