Exam 6 – Pharm Questions and Answers
A+ Guide 2025
Pharmacologic uses to kill cancer are known as: - correct answers - Anticancer drug
- Cancer chemotherapeutic agents
- Antineoplastic drugs
- Cytotoxic drugs
More than 1 mutation is required before a _______________________ can develop. - correct
answers malignancy
5 Phases of cell cycle process - correct answers Gap 1 (G1) - Growth and preparation
Synthesis (S) - DNA synthesis
Gap 2 (G2) - Further growth and preparation
Mitosis (M) - Mitosis/Cell division
Gap 0 (G0) - Dormant phase/resting phase
Most tumors grow in the _________________ phase - correct answers Gap 0 (G0)
Anticancer drugs - correct answers stop or slow the growth of cancer cells; interfere w/cell
replication classified according to their action
Cell Cycle Nonspecific (CCNS) drugs - correct answers acts during any phase of the cell
cycle; alkylating drugs, anti-tumor antibiotics, hormones
Cell Cycle Specific drugs (CCS) - correct answers drugs that are cytotoxic during a specific
phase of the cell cycle; most effective against rapidly growing cancer cells;
antimetabolites, alkylating agents, vinca alkaloids
,Exam 6 – Pharm Questions and Answers
A+ Guide 2025
nadir - correct answers time the blood count is the lowest
When does the nadir occur after chemotherapy treatment? - correct answers 7-10 days
after a chemo treatment
*infection risks are most high during this time
Adjuvant therapy - correct answers surgery is done first; then chemo is used to eliminate
any residual cancer cells
Neoadjuvant therapy - correct answers chemo is given first to shrink large tumors so they
can be surgically removed
Palliative chemotherapy - correct answers advanced disease state; relieves symptoms
such as pain or shortness of air; improves quality of life
Combinating chemotherapy - correct answers enhances tumoricidal activity; increases
chance of affecting cancer cells in all phases of cell cycle; increases synergistic effects to
kill chance; decreases drug resistance
General side effects and adverse effects of chemo - correct answers affects skin and hair
growth, GI tract, mucous membranes, bone marrow, reproductive systems
Alkylating Agents action and SE - correct answers Damage cell's DNA preventing
reproduction of cancer cells
*ex: cyclophosphamide
, Exam 6 – Pharm Questions and Answers
A+ Guide 2025
SE: anaphylaxis, hemorrhagic, cystitis, cardiomyopathy, GI distress, stomatitis, wt loss,
fever, increased skin pigmentation
Alkylating Agents drug interactions - correct answers Aspirin, allopurinol, Phenobarbital,
warfarin; cautious w/garlic, ginseng
Antimetabolites action - correct answers affects cells w/high metabolic rates, such as
hair follicles, endothelium, GI tract cells, bone marrow, causes apoptosis cells
Antimetabolites example and uses - correct answers methotrexate
Uses: treats malignant and nonmalignant; RA; psoriasis, leukemias, cancers of the GI,
head, neck, breasts, ovaries
Antimetabolites interactions - correct answers PCN and PPI's can cause toxicity; Toxic to
pregnant pts
Give NSAIDs before, with, and after this medication. - correct answers methotrexate
Anti-tumor antibiotics action and SE - correct answers Interferes w/DNA replication and
RNA transcription of cancer cels
SE: reddish colored urine, stomatitis, rash, fever, hyperpigmentation of nail beds,
cardiotoxicity
Anti-tumor antibiotics example and uses - correct answers doxorubicin
A+ Guide 2025
Pharmacologic uses to kill cancer are known as: - correct answers - Anticancer drug
- Cancer chemotherapeutic agents
- Antineoplastic drugs
- Cytotoxic drugs
More than 1 mutation is required before a _______________________ can develop. - correct
answers malignancy
5 Phases of cell cycle process - correct answers Gap 1 (G1) - Growth and preparation
Synthesis (S) - DNA synthesis
Gap 2 (G2) - Further growth and preparation
Mitosis (M) - Mitosis/Cell division
Gap 0 (G0) - Dormant phase/resting phase
Most tumors grow in the _________________ phase - correct answers Gap 0 (G0)
Anticancer drugs - correct answers stop or slow the growth of cancer cells; interfere w/cell
replication classified according to their action
Cell Cycle Nonspecific (CCNS) drugs - correct answers acts during any phase of the cell
cycle; alkylating drugs, anti-tumor antibiotics, hormones
Cell Cycle Specific drugs (CCS) - correct answers drugs that are cytotoxic during a specific
phase of the cell cycle; most effective against rapidly growing cancer cells;
antimetabolites, alkylating agents, vinca alkaloids
,Exam 6 – Pharm Questions and Answers
A+ Guide 2025
nadir - correct answers time the blood count is the lowest
When does the nadir occur after chemotherapy treatment? - correct answers 7-10 days
after a chemo treatment
*infection risks are most high during this time
Adjuvant therapy - correct answers surgery is done first; then chemo is used to eliminate
any residual cancer cells
Neoadjuvant therapy - correct answers chemo is given first to shrink large tumors so they
can be surgically removed
Palliative chemotherapy - correct answers advanced disease state; relieves symptoms
such as pain or shortness of air; improves quality of life
Combinating chemotherapy - correct answers enhances tumoricidal activity; increases
chance of affecting cancer cells in all phases of cell cycle; increases synergistic effects to
kill chance; decreases drug resistance
General side effects and adverse effects of chemo - correct answers affects skin and hair
growth, GI tract, mucous membranes, bone marrow, reproductive systems
Alkylating Agents action and SE - correct answers Damage cell's DNA preventing
reproduction of cancer cells
*ex: cyclophosphamide
, Exam 6 – Pharm Questions and Answers
A+ Guide 2025
SE: anaphylaxis, hemorrhagic, cystitis, cardiomyopathy, GI distress, stomatitis, wt loss,
fever, increased skin pigmentation
Alkylating Agents drug interactions - correct answers Aspirin, allopurinol, Phenobarbital,
warfarin; cautious w/garlic, ginseng
Antimetabolites action - correct answers affects cells w/high metabolic rates, such as
hair follicles, endothelium, GI tract cells, bone marrow, causes apoptosis cells
Antimetabolites example and uses - correct answers methotrexate
Uses: treats malignant and nonmalignant; RA; psoriasis, leukemias, cancers of the GI,
head, neck, breasts, ovaries
Antimetabolites interactions - correct answers PCN and PPI's can cause toxicity; Toxic to
pregnant pts
Give NSAIDs before, with, and after this medication. - correct answers methotrexate
Anti-tumor antibiotics action and SE - correct answers Interferes w/DNA replication and
RNA transcription of cancer cels
SE: reddish colored urine, stomatitis, rash, fever, hyperpigmentation of nail beds,
cardiotoxicity
Anti-tumor antibiotics example and uses - correct answers doxorubicin
