Cancer Bio final Questions and Answers A+
Guide
Karotype is the number and appearance of chromosomes - correct answers true
Euploidy is - normal karyotype
Aneuploidy - abnormal karyotype - correct answers true
Central Dogma of life: DNA to Protein to RNA - correct answers false
Because of fact like splicing in drosophila 1 gene can produce 38,016 different mRNAs -
correct answers true
Nucleosome is a complex of histone core over which DNA is would 2 times - correct
answers false
Modifications in histone tail can lead to cancer - correct answers true
glucose uptake and mitogenic activity is reduced in cancer cells - correct answers false
cancer progresses in stages, like hyperplastic, metaplastic, dysplastic, and invasion -
correct answers true
In coffee, caffeic acid at 11.6 mg/g exhibits carcinogenicity in Ames test. Why doesn't
coffee cause widespread cancers - correct answers -pure caffeic acid might not reach
these high concentrations in average serving
-caffeic acid might be conjugated with other natural products
,Cancer Bio final Questions and Answers A+
Guide
cancers are always names according to the organ in which they arise. However, when a
cancer metastasizes to another part of the body, it is named according to the secondary
site - correct answers false
no matter how sophisticated human life seems to be, it all starts with a single, newly
fertilized cell - correct answers true
most of the cancer cases in the world are carcinomas - correct answers true
Monoclonals arise from a single cell and polyclonal arise from different cells/tissues -
correct answers true
the histone core in a nucleosome has following histone proteins - correct answers H2A,
H2B, H3, H4
a chromosome is divided into p-arm and q-arm (short & long) - correct answers true
a gene location 3q31.1 would show a gene on chromosome #3, q arm, region 3, band 1,
sub-band 1 - correct answers true
1909 Dr Peyton Rous showed the chicken breast tumors can be infective and spread
through RNA virus RSV. - correct answers true
what are the properties of transformer cells - correct answers -anchorage independence
-foci formation
-altered cell shaped
(all of the above)
,Cancer Bio final Questions and Answers A+
Guide
Nude mice are used to monitor the transformed cells - correct answers -one can usually
monitor the tumor growth
-because they have impaired immune system and foreign cells grow in them
RSV is an RNA virus, how does it transform cells with DNA as genetic material - correct
answers it has reverse transcriptase
cancer causing properties of RSV and ALV gave rise to the concept of oncogenes, proto-
oncogenes, and concepts like c-myc/v-myc; c/src/-vsrc - correct answers true
oncogenes can be activated by chemicals - correct answers true
NIH 3T3 cells wen transfected with DNA from bladder cancer transformed these cells. The
southern blot on these cells indicated a over expression of gene similar to Harvey murine
sarcoma virus. The protein produced by this gene or the gene itself was observed to be
mutated (G12V). This would lead to altered MAP kinase signaling. - correct answers true
EBV and malaria work together, that means if any one is developed world is infected by EBV
it is highly likely they will not have Burkitt's lymphoma - correct answers true
In Burkitt's lymphomas myc gene comes under the influence of IgC and malaria causes
overexpression go IgC and thus cell transforming gene myc - correct answers false
chronic myelogenous leukemia leads to formation of Bcr-Abl hybrid protein due to
reciprocal translocation of the genes between chromosome 9 and 22. Bcr-Abl is a kinase of
Ser/Thr type - correct answers false
, Cancer Bio final Questions and Answers A+
Guide
chemicals can activate oncogenes - correct answers true
viral infections are responsible for - correct answers 20% cancers
Kaplan Meier plot of HER2 positive and HER2 negative breast cancers shows poor
prognosis for positive one with 60% dying with 12 months of detection. This breast cancer
is curable today. - correct answers true
EBV is to Burkitt's lymphoma as RSV is to sarcoma - correct answers true
Bladder cancer exhibited gene corresponding to H-ras activated, Breast Cancer K-ras
activated, colon cancer src activation... is it true? - correct answers true
fibroblasts grow robustly when the growth factor PDGF is applied to cells having PDGF-r
receptor - correct answers true
Receptor tyrosine kinases all need ectodomain to bind GF for activation - correct answers
of Tyrosine kinase on the cytoplasmic domain
receptor tyrosine kinase usually a monomer and dimerizes upon activation by growth factor
- correct answers true
endocrine secretion of growth factors leads to an activation of - correct answers remote
cells through blood transport
erbB oncogene implicated in breast cancer was found to express as receptor Tyrosine
kinase, with extracellular domain truncated. - correct answers true
Guide
Karotype is the number and appearance of chromosomes - correct answers true
Euploidy is - normal karyotype
Aneuploidy - abnormal karyotype - correct answers true
Central Dogma of life: DNA to Protein to RNA - correct answers false
Because of fact like splicing in drosophila 1 gene can produce 38,016 different mRNAs -
correct answers true
Nucleosome is a complex of histone core over which DNA is would 2 times - correct
answers false
Modifications in histone tail can lead to cancer - correct answers true
glucose uptake and mitogenic activity is reduced in cancer cells - correct answers false
cancer progresses in stages, like hyperplastic, metaplastic, dysplastic, and invasion -
correct answers true
In coffee, caffeic acid at 11.6 mg/g exhibits carcinogenicity in Ames test. Why doesn't
coffee cause widespread cancers - correct answers -pure caffeic acid might not reach
these high concentrations in average serving
-caffeic acid might be conjugated with other natural products
,Cancer Bio final Questions and Answers A+
Guide
cancers are always names according to the organ in which they arise. However, when a
cancer metastasizes to another part of the body, it is named according to the secondary
site - correct answers false
no matter how sophisticated human life seems to be, it all starts with a single, newly
fertilized cell - correct answers true
most of the cancer cases in the world are carcinomas - correct answers true
Monoclonals arise from a single cell and polyclonal arise from different cells/tissues -
correct answers true
the histone core in a nucleosome has following histone proteins - correct answers H2A,
H2B, H3, H4
a chromosome is divided into p-arm and q-arm (short & long) - correct answers true
a gene location 3q31.1 would show a gene on chromosome #3, q arm, region 3, band 1,
sub-band 1 - correct answers true
1909 Dr Peyton Rous showed the chicken breast tumors can be infective and spread
through RNA virus RSV. - correct answers true
what are the properties of transformer cells - correct answers -anchorage independence
-foci formation
-altered cell shaped
(all of the above)
,Cancer Bio final Questions and Answers A+
Guide
Nude mice are used to monitor the transformed cells - correct answers -one can usually
monitor the tumor growth
-because they have impaired immune system and foreign cells grow in them
RSV is an RNA virus, how does it transform cells with DNA as genetic material - correct
answers it has reverse transcriptase
cancer causing properties of RSV and ALV gave rise to the concept of oncogenes, proto-
oncogenes, and concepts like c-myc/v-myc; c/src/-vsrc - correct answers true
oncogenes can be activated by chemicals - correct answers true
NIH 3T3 cells wen transfected with DNA from bladder cancer transformed these cells. The
southern blot on these cells indicated a over expression of gene similar to Harvey murine
sarcoma virus. The protein produced by this gene or the gene itself was observed to be
mutated (G12V). This would lead to altered MAP kinase signaling. - correct answers true
EBV and malaria work together, that means if any one is developed world is infected by EBV
it is highly likely they will not have Burkitt's lymphoma - correct answers true
In Burkitt's lymphomas myc gene comes under the influence of IgC and malaria causes
overexpression go IgC and thus cell transforming gene myc - correct answers false
chronic myelogenous leukemia leads to formation of Bcr-Abl hybrid protein due to
reciprocal translocation of the genes between chromosome 9 and 22. Bcr-Abl is a kinase of
Ser/Thr type - correct answers false
, Cancer Bio final Questions and Answers A+
Guide
chemicals can activate oncogenes - correct answers true
viral infections are responsible for - correct answers 20% cancers
Kaplan Meier plot of HER2 positive and HER2 negative breast cancers shows poor
prognosis for positive one with 60% dying with 12 months of detection. This breast cancer
is curable today. - correct answers true
EBV is to Burkitt's lymphoma as RSV is to sarcoma - correct answers true
Bladder cancer exhibited gene corresponding to H-ras activated, Breast Cancer K-ras
activated, colon cancer src activation... is it true? - correct answers true
fibroblasts grow robustly when the growth factor PDGF is applied to cells having PDGF-r
receptor - correct answers true
Receptor tyrosine kinases all need ectodomain to bind GF for activation - correct answers
of Tyrosine kinase on the cytoplasmic domain
receptor tyrosine kinase usually a monomer and dimerizes upon activation by growth factor
- correct answers true
endocrine secretion of growth factors leads to an activation of - correct answers remote
cells through blood transport
erbB oncogene implicated in breast cancer was found to express as receptor Tyrosine
kinase, with extracellular domain truncated. - correct answers true
