VPHY 4600 Neurotoxicology Drugs of Abuse

VPHY 4600 Neurotoxicology Drugs of
Abuse
adrenergic - ANSWERS? receptors mediate sympathetic signaling


alpha-1 - ANSWERSadrenergic receptor for vascular smooth muscle


alpha-2 - ANSWERSadrenergic receptor in CNS and small amount of vascular smooth muscle


beta-1 - ANSWERSadrenergic receptor in heart and CNS


beta-2 - ANSWERSadrenergic receptor in bronchial smooth muscle, vascular smooth muscle, skeletal muscle,
CNS, and a little bit of cardiac muscle


alpha-1 - ANSWERSadrenergic receptor that causes vasoconstriction, increased peripheral resistance,
increased BP, and mydriasis


beta-1 - ANSWERSadrenergic receptor that causes tachycardia and increased myocardial contractility


beta-2 - ANSWERSadrenergic receptor that causes vasodilation, slightly decreased peripheral resistance, and
bronchodilation


phenylpropanolamine (PPA, norephedrine) - ANSWERSoriginal use: appetite suppressant or decongestant in
human OTC meds--in 2000, FDA advised removal of it from human products due to risk of hypertension and
stroke; causes NE release (from basically all sympathetic neurons) -> stimulates alpha and beta receptors ->
many peripheral effects but enters CNS to some extent also; an active metabolite of amphetamine; currently
used to manage urinary incontinence in dogs


sympathetic - ANSWERSbladder filling: ? NS predominates