►
7i
h,ov-...., Jo c. ell p-roc.e£ses Oc.c..v-r 'u ~ o vv c on.. ""'e co n.-\-ro\ -,-h ero .
-1...,nde,st-ar-d i ng ~act-ors ;,,-y-,pon::on t-- v, -tne cle:-<;;;i9 f""\ t, s elec1:_., b n of-
0 1 orro-\-ef,af;'
J OCOJ q re-a J
s-t-rvc-h.,'"" e - pr-Ope,-l-y -1:'fpe s o-\-- 'o '() 'l"l")o+e.r, 0 1,;;
• bi oc.ornpo-t-'i b , L·, \- y · b1orr101-er10.l sete ct i<:::>r-.
def, nifions
1. A non.,-viab/e mo-teria/ usecl in a rnec/ica/ device no+ 1riter,ded 4' -to
1n+-er-ac-t vv/ bi0\0:3 1 ca1 Systems
2 . A
~ ·t::'hcse d~,n, CIO\f.:; f-QCVS Q("\ lce\rq ·,"<Je,-t,but not-nir-,g ·,'2, +r-v\'7' \ner--\:;
<T10~1<Il +rat- inter--oc\--'S "YV 1\:-h
0
3. a. viold.e O'r <lO'n viab\e t--'ne biol~ical
envi ""o-nn,e<"\b l, 1-\:S -h..... nc.\- "1e>n \5 -1::o dioq0ose , tree+ / Support; ovgme0t O '<
r-eo\a.ce po,t. o, all of o Liv·,:13 S'/S-1-em _
c Dn.icat needs for b;orriatcnal.s
biolcq·,ca1 qraf---\-£
➔ OLrt-oq,afi- - from 'y'ou,,...self-
~ otLoq,of+ - f,ort) sorneore eise cte-rnond
➔ X'enog ,a-f--\--s - from on\trrne< spe.c\es;;
~ con<o1de..- p,OS O CO\""")S cl e:;ach 9'°---r-T
· c.o",,i,dev- bi o~v nc~\onoLH::y CZJ biocornP=t-tibi li+y
~ ·,0-f lOl'fln'at10° ➔ a\le-rg,c:.. reGPart3e
4 wovnd heolirg -, \ rifect'lon
• nOSt Y-eGp:)~ m o \-et", 0 \ res~ r, 9=
_,_ 1n.i 'clo I events: -K:.Or1... 0'S-t6Y"\
➔ i "f\.f- \om fY""I a \-I en -, fa-t,gue
-'> irnmvno\cx3'1cal . ..:i, +rCl C t"U\"e'
➔ en'Z.y mat ·,c ➔ deg ,oda-hOt"\
I/
-bocte,no.L "infecbo0 _., od~Or-ption Locs o~ t.',a \
_., neopto<;:·o. and e-r-ror ' 1
, tr~ dr \'.J·,cnro1€'t·,o,c:
Me-\-QlS
· o~~,·, C()T1C)'I\ · c,m·, tot-\ons
4 l oocl \:::eQri r-,9 ~c;;+-re~ ,;-'r\1e\d1~
-, ·Jo,nt- ("e~\cx:.cme"'\- -, 'oicx.om~be- -} co,,os;.., 6n
_, f-',x~,cf1 de.v·,c.e, co~ti,o ➔b\ocdcornp:th\:Jle 4 ra\- ·, gve 1., '-NE=O •
vvho\- s+reo~ shi e\d1nq?
\C
. t=>vtti n.9 more stress/ l.<x)d on +re \mp\on+ ti -t-'ne ot;ner
·,s wea\lened b/c ·,ts; not dc,rg \/VO'r"'V-
Ce'\am,c..s
· a.pp\·1 ccrho0 • advonto.ge . \,·,rn,-ta.--0on)
-+l.Qod-teonng ~ontr C>\ \ob\e -'I -fr-a~
➔ .)()\rL-t"
~ bioo:>rn\:X)t\be/lnert
~ Ort:'fl08='d1C ➔ Lub,i~on
--, b,orrY,rneb,c
.Po\yrne<.s
OPV,G cai-bD ·odv • \'1 rr, ·,-tot-1 D ns-
~survr-eS 7 con-\-,D \lob 'c°' ~ V...eQ\(
drug-delivery --l-d cx:::ornfC-1_~ ,b\c ..::, :rri',st:1 otcn ·,r, pro~-Mc .s-
-ei
➔ b,ooeg md obe ~ d ~ion µn:x::h.; cts
e·,o ~c:g\co\ Mo-ler-',a ts
· appL,cabc:>t)S' ·advornc:x:aeG
➔ vv O\..J nd d re~ O:_J ~bi q-n\ ~ \ c -. CX~'\Ye"
~ drug de.l'ive ,Y -, b1ooom \:Dt'1b'e ➔ in-\'.-e'4 or- rnecro n\ ca L
__,, i,S~\..)-e: e;n91~l°3 P roper-t\es
~ 11m·1-ted ~uppt.y
,, arro119e\"r\e-nt g ·~s vc:;: d1-f-fe,e0c ~,o~e r bes
. rnob-e,·, al SelecbOI") G-t,o.tegy
_. rnet'l.l, ce-ro m\c I Poly me-<
I() m ; C.l""OYl S
se-ve -. o 1
~
~ C.ell
9...-01ns
) I mm \-"(_· 1rnl'\'l o . 1 - I nm -< D. I n.rn
d~-pe~c:le,...., \- o....._
4 c, ~n-ic loovx::i
o-6-orns
d; ~~r-en. :r types of- b<::>rd'3
w otl-,er bords;'
• i c:,Y"""'li.C: c.eroYl"l°iC ( 5t.ron~s-\:f:._ <o()O- 1'366 kJ / mo\ ~ hydro<3e"
__, - Von 4e...- \.Vool 's-
- e\ect,0$-l'S ore eho.red bc""'1n \oD~h 0-t-~y-y-'5'
• ~taLL; c....: rneto\S
➔ c...ondvc-t-·r ve 'o(c of- free e\cct-ron clo vd b iDn ccl'"eS
c. cr,~·,ciev-·,r,g Cl ,ron9eTT1C().-\::;
• La.tt;c.es 9·•"e ~<;;;e to d• E-feren¼ prope,t.-, e s
~ ~
• b----\ \.:... ?ropc....-t:·,-es
• ......,...,-ec.hon;c\..
criorge t> c..'"'-em,c..o.l comp
• -\,-r-,err-nc:ll • Surra~ ten~•on l) ev-.e.'"'3)"
T'r'Q.-i::e(• o.t proper+ie5 ( ni -ti::> \o')
. de..n.5 ,-t:v : rne t:Q.L _, ceV""Cl rr,,c ➔
c:.onovcJ;:;\vi t-y
. l"l)ecnon.i c.a.L. ,..,....,et-al ~ c..-erGYYl°iCS _, yoc,yme,5 ➔ c.o vnp csiteG
, 10 O°I 2 02 3
e \ec'\-roeo -rd·, cgra rn ·.
· v'\h I \~n) e·, ~\'""'I D'Je.f"L.
. ,~-~vnc
• cz., \'-1-eT" ""·,v-~ fV"ov-ed -rn:y-- w/ he:::>,rt-
. used p0c:,c-ogrQphiC paper to record r("lovemen+
c.. 0
IT"lpo~'("'IT43 of- Cl bi <:)n")edi ca.1 device·.
- bio -eensor · a.rd c.on..ve-<" t- er-:
- ci t"1 "lp1·, fie, 1,.. d y c.ui l::-9 ~ 4 di spt oy ~'<"ecord/G+oroge
· gain J s,~o~H-1o01rg 14 ctigH-o' stqna1
· v--., n Q-'t- \ ·s a se0 s or '?
4 d-ev\c:..,e +no\-- c..a~,,ev-\-s a. ph'-f-i1ca\ s\gna\ '31 ,1-s "lor:o ~O\l
·,n1-o on e\CC\-r-·,co\ 6ign.o \
· w\1Q.\- ·,s o ~ransduce~:
Y converts a pn..yeicoJ s\groL 1n.-to ono+-'neY- -t"{f:>e c::,f
?hy<o\ co\ G\gnal ( -r-hen-y, oresist-o<)
b 1os\gnols ,nclude:
~ +ef"") p ~ -f (OV'v
~ fa'rc'("" -, pc::F-, ,t-", on
~ prs~r-e __.,e\ectr-icol t=>Oten-ho\
1lr;-f!/J'Z/bffl.,, .ef>er~.,a,~.en~
active SeOGO<
--t needs e')('..+eY-f\O\ eource. er. e>".c·, ~ · , on
➔ -eg·. ree·, sta.nc.e- t:)Clsed: 5e~,s
.. a cun-en+ mvat be p::)s~ed -tnr~n -\-'nem &i
c..oY-respc,od;~ i.--. .----i
+""'e CUI I ec ,+~ vo1-to9e v--i\\\ '-'v r<easurc:,....r -to de+e~rn·, ne
~'he ree\stoOQ:- VO. I\Je
pass,ve aera::::r
-, ro::::,\c:eS it-e:, own eiecmcoL ov+-put- si.gnal w/o extern.at
vo\+ages or cu~ren,t
___,. e. g: t nerv-noc ov p,es
· gene"ate on.. cleot-r'ical \i'Ott-oqe
sen5·r\::-•,vity: rono of- cu-rput- cha ~-e -to ct ~·,ven c:.nonqe \f"'
·,n...p\.A-
1--!J n:~ sen-ca·, tivit-y s ma\,l cnonqe ·1~t- ~ lor~ c.nonge ·,n ovtpu+- ,n.
e)(.: ~ernperatvre sen-et>r
A·. O- \ 0 c --t
B·. 0 - 100° _.. Q-\DV
O - \0 V \ I • •
f6
7i
h,ov-...., Jo c. ell p-roc.e£ses Oc.c..v-r 'u ~ o vv c on.. ""'e co n.-\-ro\ -,-h ero .
-1...,nde,st-ar-d i ng ~act-ors ;,,-y-,pon::on t-- v, -tne cle:-<;;;i9 f""\ t, s elec1:_., b n of-
0 1 orro-\-ef,af;'
J OCOJ q re-a J
s-t-rvc-h.,'"" e - pr-Ope,-l-y -1:'fpe s o-\-- 'o '() 'l"l")o+e.r, 0 1,;;
• bi oc.ornpo-t-'i b , L·, \- y · b1orr101-er10.l sete ct i<:::>r-.
def, nifions
1. A non.,-viab/e mo-teria/ usecl in a rnec/ica/ device no+ 1riter,ded 4' -to
1n+-er-ac-t vv/ bi0\0:3 1 ca1 Systems
2 . A
~ ·t::'hcse d~,n, CIO\f.:; f-QCVS Q("\ lce\rq ·,"<Je,-t,but not-nir-,g ·,'2, +r-v\'7' \ner--\:;
<T10~1<Il +rat- inter--oc\--'S "YV 1\:-h
0
3. a. viold.e O'r <lO'n viab\e t--'ne biol~ical
envi ""o-nn,e<"\b l, 1-\:S -h..... nc.\- "1e>n \5 -1::o dioq0ose , tree+ / Support; ovgme0t O '<
r-eo\a.ce po,t. o, all of o Liv·,:13 S'/S-1-em _
c Dn.icat needs for b;orriatcnal.s
biolcq·,ca1 qraf---\-£
➔ OLrt-oq,afi- - from 'y'ou,,...self-
~ otLoq,of+ - f,ort) sorneore eise cte-rnond
➔ X'enog ,a-f--\--s - from on\trrne< spe.c\es;;
~ con<o1de..- p,OS O CO\""")S cl e:;ach 9'°---r-T
· c.o",,i,dev- bi o~v nc~\onoLH::y CZJ biocornP=t-tibi li+y
~ ·,0-f lOl'fln'at10° ➔ a\le-rg,c:.. reGPart3e
4 wovnd heolirg -, \ rifect'lon
• nOSt Y-eGp:)~ m o \-et", 0 \ res~ r, 9=
_,_ 1n.i 'clo I events: -K:.Or1... 0'S-t6Y"\
➔ i "f\.f- \om fY""I a \-I en -, fa-t,gue
-'> irnmvno\cx3'1cal . ..:i, +rCl C t"U\"e'
➔ en'Z.y mat ·,c ➔ deg ,oda-hOt"\
I/
-bocte,no.L "infecbo0 _., od~Or-ption Locs o~ t.',a \
_., neopto<;:·o. and e-r-ror ' 1
, tr~ dr \'.J·,cnro1€'t·,o,c:
Me-\-QlS
· o~~,·, C()T1C)'I\ · c,m·, tot-\ons
4 l oocl \:::eQri r-,9 ~c;;+-re~ ,;-'r\1e\d1~
-, ·Jo,nt- ("e~\cx:.cme"'\- -, 'oicx.om~be- -} co,,os;.., 6n
_, f-',x~,cf1 de.v·,c.e, co~ti,o ➔b\ocdcornp:th\:Jle 4 ra\- ·, gve 1., '-NE=O •
vvho\- s+reo~ shi e\d1nq?
\C
. t=>vtti n.9 more stress/ l.<x)d on +re \mp\on+ ti -t-'ne ot;ner
·,s wea\lened b/c ·,ts; not dc,rg \/VO'r"'V-
Ce'\am,c..s
· a.pp\·1 ccrho0 • advonto.ge . \,·,rn,-ta.--0on)
-+l.Qod-teonng ~ontr C>\ \ob\e -'I -fr-a~
➔ .)()\rL-t"
~ bioo:>rn\:X)t\be/lnert
~ Ort:'fl08='d1C ➔ Lub,i~on
--, b,orrY,rneb,c
.Po\yrne<.s
OPV,G cai-bD ·odv • \'1 rr, ·,-tot-1 D ns-
~survr-eS 7 con-\-,D \lob 'c°' ~ V...eQ\(
drug-delivery --l-d cx:::ornfC-1_~ ,b\c ..::, :rri',st:1 otcn ·,r, pro~-Mc .s-
-ei
➔ b,ooeg md obe ~ d ~ion µn:x::h.; cts
e·,o ~c:g\co\ Mo-ler-',a ts
· appL,cabc:>t)S' ·advornc:x:aeG
➔ vv O\..J nd d re~ O:_J ~bi q-n\ ~ \ c -. CX~'\Ye"
~ drug de.l'ive ,Y -, b1ooom \:Dt'1b'e ➔ in-\'.-e'4 or- rnecro n\ ca L
__,, i,S~\..)-e: e;n91~l°3 P roper-t\es
~ 11m·1-ted ~uppt.y
,, arro119e\"r\e-nt g ·~s vc:;: d1-f-fe,e0c ~,o~e r bes
. rnob-e,·, al SelecbOI") G-t,o.tegy
_. rnet'l.l, ce-ro m\c I Poly me-<
I() m ; C.l""OYl S
se-ve -. o 1
~
~ C.ell
9...-01ns
) I mm \-"(_· 1rnl'\'l o . 1 - I nm -< D. I n.rn
d~-pe~c:le,...., \- o....._
4 c, ~n-ic loovx::i
o-6-orns
d; ~~r-en. :r types of- b<::>rd'3
w otl-,er bords;'
• i c:,Y"""'li.C: c.eroYl"l°iC ( 5t.ron~s-\:f:._ <o()O- 1'366 kJ / mo\ ~ hydro<3e"
__, - Von 4e...- \.Vool 's-
- e\ect,0$-l'S ore eho.red bc""'1n \oD~h 0-t-~y-y-'5'
• ~taLL; c....: rneto\S
➔ c...ondvc-t-·r ve 'o(c of- free e\cct-ron clo vd b iDn ccl'"eS
c. cr,~·,ciev-·,r,g Cl ,ron9eTT1C().-\::;
• La.tt;c.es 9·•"e ~<;;;e to d• E-feren¼ prope,t.-, e s
~ ~
• b----\ \.:... ?ropc....-t:·,-es
• ......,...,-ec.hon;c\..
criorge t> c..'"'-em,c..o.l comp
• -\,-r-,err-nc:ll • Surra~ ten~•on l) ev-.e.'"'3)"
T'r'Q.-i::e(• o.t proper+ie5 ( ni -ti::> \o')
. de..n.5 ,-t:v : rne t:Q.L _, ceV""Cl rr,,c ➔
c:.onovcJ;:;\vi t-y
. l"l)ecnon.i c.a.L. ,..,....,et-al ~ c..-erGYYl°iCS _, yoc,yme,5 ➔ c.o vnp csiteG
, 10 O°I 2 02 3
e \ec'\-roeo -rd·, cgra rn ·.
· v'\h I \~n) e·, ~\'""'I D'Je.f"L.
. ,~-~vnc
• cz., \'-1-eT" ""·,v-~ fV"ov-ed -rn:y-- w/ he:::>,rt-
. used p0c:,c-ogrQphiC paper to record r("lovemen+
c.. 0
IT"lpo~'("'IT43 of- Cl bi <:)n")edi ca.1 device·.
- bio -eensor · a.rd c.on..ve-<" t- er-:
- ci t"1 "lp1·, fie, 1,.. d y c.ui l::-9 ~ 4 di spt oy ~'<"ecord/G+oroge
· gain J s,~o~H-1o01rg 14 ctigH-o' stqna1
· v--., n Q-'t- \ ·s a se0 s or '?
4 d-ev\c:..,e +no\-- c..a~,,ev-\-s a. ph'-f-i1ca\ s\gna\ '31 ,1-s "lor:o ~O\l
·,n1-o on e\CC\-r-·,co\ 6ign.o \
· w\1Q.\- ·,s o ~ransduce~:
Y converts a pn..yeicoJ s\groL 1n.-to ono+-'neY- -t"{f:>e c::,f
?hy<o\ co\ G\gnal ( -r-hen-y, oresist-o<)
b 1os\gnols ,nclude:
~ +ef"") p ~ -f (OV'v
~ fa'rc'("" -, pc::F-, ,t-", on
~ prs~r-e __.,e\ectr-icol t=>Oten-ho\
1lr;-f!/J'Z/bffl.,, .ef>er~.,a,~.en~
active SeOGO<
--t needs e')('..+eY-f\O\ eource. er. e>".c·, ~ · , on
➔ -eg·. ree·, sta.nc.e- t:)Clsed: 5e~,s
.. a cun-en+ mvat be p::)s~ed -tnr~n -\-'nem &i
c..oY-respc,od;~ i.--. .----i
+""'e CUI I ec ,+~ vo1-to9e v--i\\\ '-'v r<easurc:,....r -to de+e~rn·, ne
~'he ree\stoOQ:- VO. I\Je
pass,ve aera::::r
-, ro::::,\c:eS it-e:, own eiecmcoL ov+-put- si.gnal w/o extern.at
vo\+ages or cu~ren,t
___,. e. g: t nerv-noc ov p,es
· gene"ate on.. cleot-r'ical \i'Ott-oqe
sen5·r\::-•,vity: rono of- cu-rput- cha ~-e -to ct ~·,ven c:.nonqe \f"'
·,n...p\.A-
1--!J n:~ sen-ca·, tivit-y s ma\,l cnonqe ·1~t- ~ lor~ c.nonge ·,n ovtpu+- ,n.
e)(.: ~ernperatvre sen-et>r
A·. O- \ 0 c --t
B·. 0 - 100° _.. Q-\DV
O - \0 V \ I • •
f6
