CCTN Exam Study Guide+Questions with
Correct Solutions
Pediatric indication for intestinal transplant - ANSWER Hirschsprung disease
chronic intestinal pseudo obstruction
volvulus
gastroschisis (abdominal wall herniation)
congenital atresia
necrotizing enterocolitis
trauma
short gut syndrome
Short gut syndrome - ANSWER the inability of the small intestine to adequately absorb nutrition,
fluids, and to regulate electrolytes, can be structural or functional, usually acquired
Indications for Heart Transplant - ANSWER CHF with Class 3-4 symptoms, max therapy,
reduced exercise capacity, severe O2 dependence
End stage heart disease
Myocarditis
Myxomas
Refractory angina
Restrictive, dilated, or ischemic cardiomyopathy
life-threatening V arrhythmias
Pre Transplant Diagnostic Tests - ANSWER Abdominal US
,CXR
EKG
PFT
Panorex
Right heart cath (if indicated)
Pre Transplant Lab Tests - ANSWER ABO Rh
Virology Screening
Panel Reactive Antibody
Human Leukocyte Antibody
Toxoplasma Screening
Cancer Screening
Osteoporosis Screening
TB Screening
Virology Screening - ANSWER determines recipients suitability for transplant and post
transplant infection risk; HIV, EBV, CMV, Hepatitis, RPR (syphilis), TB, toxoplasma, herpes
Panel Reactive Antibody (PRA) - ANSWER The percent PRA value is a measure of a patient's
level of sensitization to donor antigens. It is the percentage of cells from a panel of blood
donors against which a potential recipient's serum reacts. The PRA reflects the percentage of
the general population that a potential recipient makes antibodies (is sensitized) against. The
higher the PRA, the more sensitized a patient is to the general donor pool, and thus the more
difficult it is to find a suitable donor. A patient may become sensitized as a result of
pregnancy, a blood transfusion, or a previous transplant.
Human Leukocyte Antigen (HLA) - ANSWER Molecules found on all nucleated cells in the body
that help the immune system to recognize whether or not a cell is foreign to the body. Human
leukocyte antigens are used to predict likelihood of organ rejection, cannot test within 72
hours of a blood transfusion, on chromosome 6
, HIV patients candidate for transplant - ANSWER - CD4 cell count greater than 200cells/mm3
for longer than 6 months
- HIV RNA are undetectable
- HIV not progressed to AIDS
- Compliance for more than 3 months
- No opportunistic infections
Absolute Contraindication to Transplant - ANSWER - Active drinker, smoker, drug user
- AIDS
- Active infection
- Cancer
- Irreversible damage to another organ
- Diverticulitis
- "Free Bleeder," difficulty clotting
- Non-compliance
- Mental disorders
- PUD
- PE
Paired Exchange - ANSWER Two living donors who do not meet ABO compatibility.
Transplant center coordinates organ exchange for compatible organs to donate to recipients.
Indirect Exchange - ANSWER Living donor donates to first person on deceased donor transplant
list and in exchange their planned recipient moves to the first spot for a deceased donor
Non-Directed Donation - ANSWER A living donor offers a kidney as a Good Samaritan
Correct Solutions
Pediatric indication for intestinal transplant - ANSWER Hirschsprung disease
chronic intestinal pseudo obstruction
volvulus
gastroschisis (abdominal wall herniation)
congenital atresia
necrotizing enterocolitis
trauma
short gut syndrome
Short gut syndrome - ANSWER the inability of the small intestine to adequately absorb nutrition,
fluids, and to regulate electrolytes, can be structural or functional, usually acquired
Indications for Heart Transplant - ANSWER CHF with Class 3-4 symptoms, max therapy,
reduced exercise capacity, severe O2 dependence
End stage heart disease
Myocarditis
Myxomas
Refractory angina
Restrictive, dilated, or ischemic cardiomyopathy
life-threatening V arrhythmias
Pre Transplant Diagnostic Tests - ANSWER Abdominal US
,CXR
EKG
PFT
Panorex
Right heart cath (if indicated)
Pre Transplant Lab Tests - ANSWER ABO Rh
Virology Screening
Panel Reactive Antibody
Human Leukocyte Antibody
Toxoplasma Screening
Cancer Screening
Osteoporosis Screening
TB Screening
Virology Screening - ANSWER determines recipients suitability for transplant and post
transplant infection risk; HIV, EBV, CMV, Hepatitis, RPR (syphilis), TB, toxoplasma, herpes
Panel Reactive Antibody (PRA) - ANSWER The percent PRA value is a measure of a patient's
level of sensitization to donor antigens. It is the percentage of cells from a panel of blood
donors against which a potential recipient's serum reacts. The PRA reflects the percentage of
the general population that a potential recipient makes antibodies (is sensitized) against. The
higher the PRA, the more sensitized a patient is to the general donor pool, and thus the more
difficult it is to find a suitable donor. A patient may become sensitized as a result of
pregnancy, a blood transfusion, or a previous transplant.
Human Leukocyte Antigen (HLA) - ANSWER Molecules found on all nucleated cells in the body
that help the immune system to recognize whether or not a cell is foreign to the body. Human
leukocyte antigens are used to predict likelihood of organ rejection, cannot test within 72
hours of a blood transfusion, on chromosome 6
, HIV patients candidate for transplant - ANSWER - CD4 cell count greater than 200cells/mm3
for longer than 6 months
- HIV RNA are undetectable
- HIV not progressed to AIDS
- Compliance for more than 3 months
- No opportunistic infections
Absolute Contraindication to Transplant - ANSWER - Active drinker, smoker, drug user
- AIDS
- Active infection
- Cancer
- Irreversible damage to another organ
- Diverticulitis
- "Free Bleeder," difficulty clotting
- Non-compliance
- Mental disorders
- PUD
- PE
Paired Exchange - ANSWER Two living donors who do not meet ABO compatibility.
Transplant center coordinates organ exchange for compatible organs to donate to recipients.
Indirect Exchange - ANSWER Living donor donates to first person on deceased donor transplant
list and in exchange their planned recipient moves to the first spot for a deceased donor
Non-Directed Donation - ANSWER A living donor offers a kidney as a Good Samaritan
