Nanomedicine Midterm Prep PRACTICE
QUESTIONS WITH ANSWERS 2024/2025.
Define nanomedicine and list at least three different applications of nanomedicine. -
Nanomedicine is the use of nano-biotechnology in medicine. Different applications of
nanomedicine include imaging agents and diagnostics, real-time assessment to
accelerate clinical translation, multifunctional targeted devices, monitoring predictive
molecular changes, and research enablers like chip-based nano-labs.
Name four examples of FDA-approved nanotechnology-based products, and explain
one advantage of using nanocarriers in drug delivery. - Four examples of FDA-approved
nanotechnology-based products are Abraxane, Doxil, Feraheme, and Mycamine. An
advantage of using nanocarriers in drug delivery is the enhanced targeting and delivery
of therapeutic agents to specific cells or tissues, reducing off-target effects and
improving treatment efficacy.
What physicochemical characteristics influence the toxicity and biodistribution of
nanoconstructs? Provide examples of physical and chemical characteristics. -
Physicochemical characteristics influencing nanoconstructs toxicity and biodistribution
include physical characteristics like size, surface area, and shape, and chemical
characteristics like charge, hydrophobicity/hydrophilicity, and surface chemistry. For
instance, a smaller size and a positive charge may increase cellular uptake, while
hydrophobicity can affect solubility and toxicity.
Summarize the findings reported in the research article "Multivalent HER2-binding
polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery."
- The research co-opts crosslinking-mediated internalization for efficient intracellular
delivery of an anticancer nanomedicine, particularly an HPMA copolymer-based drug
delivery system. The study synthesized and characterized HPMA copolymers-affibody
conjugates, demonstrating that higher valence conjugates enhanced intracellular drug
delivery and cytotoxicity against HER2-positive cells.
What polymerization technique was used in the synthesis of polymer conjugates in the
mentioned article, and why is it relevant for drug delivery systems? - Radical
polymerization was used in the synthesis of polymer conjugates in the article. This
technique is relevant for drug delivery systems because it allows for the controlled and
efficient formation of polymer-drug conjugates, enabling targeted drug delivery to
specific cells or tissues.
List the monomers, initiators, and chain transfer agent used for the synthesis of the
polymer-affibody conjugates. - The monomers used were HPMA and APMA. The
initiator was V50, and the chain transfer agent was 4-cyanopentanoic acid
dithiobenzoate.
QUESTIONS WITH ANSWERS 2024/2025.
Define nanomedicine and list at least three different applications of nanomedicine. -
Nanomedicine is the use of nano-biotechnology in medicine. Different applications of
nanomedicine include imaging agents and diagnostics, real-time assessment to
accelerate clinical translation, multifunctional targeted devices, monitoring predictive
molecular changes, and research enablers like chip-based nano-labs.
Name four examples of FDA-approved nanotechnology-based products, and explain
one advantage of using nanocarriers in drug delivery. - Four examples of FDA-approved
nanotechnology-based products are Abraxane, Doxil, Feraheme, and Mycamine. An
advantage of using nanocarriers in drug delivery is the enhanced targeting and delivery
of therapeutic agents to specific cells or tissues, reducing off-target effects and
improving treatment efficacy.
What physicochemical characteristics influence the toxicity and biodistribution of
nanoconstructs? Provide examples of physical and chemical characteristics. -
Physicochemical characteristics influencing nanoconstructs toxicity and biodistribution
include physical characteristics like size, surface area, and shape, and chemical
characteristics like charge, hydrophobicity/hydrophilicity, and surface chemistry. For
instance, a smaller size and a positive charge may increase cellular uptake, while
hydrophobicity can affect solubility and toxicity.
Summarize the findings reported in the research article "Multivalent HER2-binding
polymer conjugates facilitate rapid endocytosis and enhance intracellular drug delivery."
- The research co-opts crosslinking-mediated internalization for efficient intracellular
delivery of an anticancer nanomedicine, particularly an HPMA copolymer-based drug
delivery system. The study synthesized and characterized HPMA copolymers-affibody
conjugates, demonstrating that higher valence conjugates enhanced intracellular drug
delivery and cytotoxicity against HER2-positive cells.
What polymerization technique was used in the synthesis of polymer conjugates in the
mentioned article, and why is it relevant for drug delivery systems? - Radical
polymerization was used in the synthesis of polymer conjugates in the article. This
technique is relevant for drug delivery systems because it allows for the controlled and
efficient formation of polymer-drug conjugates, enabling targeted drug delivery to
specific cells or tissues.
List the monomers, initiators, and chain transfer agent used for the synthesis of the
polymer-affibody conjugates. - The monomers used were HPMA and APMA. The
initiator was V50, and the chain transfer agent was 4-cyanopentanoic acid
dithiobenzoate.
