HLSC 4P99 FINAL EXAM BRENT FAUGHT -
THERAPEUTIC TRIALS QUESTIONS WITH
100% CORRECT!!
1 of 41
Term
What does TPD stand for?
Give this one a try later!
Drugs Directorate Natural Health Products Directorate
Marketed Health Products Therapeutic Products
Directorate Directorate
, Don't know?
2 of 41
Term
What are some intervention considerations?
Give this one a try later!
1. Generalizability (standard treatment) - not patient but treatment
2.Complexity (1 or multiple treatments) - surgery, radiation, meds
3.Strength - 95/100 have have hypothyroid are successful
D+ = unhealthy
D- = healthy
T+ = Treatment
T- = placebo
P (D+ | T+) non-effective
P (D- | T+) effective
** Look at chart from lecture
1. Patient spectrum
2.Standard treatment
People need to cross over early because if they do it too late there will not be
enough data to collect on them and this data cannot be used
Don't know?
,3 of 41
Definition
Measured from having no control group
Participants are measured pre or at baseline and then measured
post
Example. they measure that they feel 20%/100% good at baseline Post
they say they feel 80%/100%
This means that the treatment have a 60% total effect!
This is used to compare to the regular treatment, if the normal
treatment total effect is 90% we wouldn't switch, however, if the total
effect was 40%, we would switch to this treatment
Give this one a try later!
What does prognostic stratification What happens if a patient switches
need to take place? from treatment to placebo group?
What is the total effect in
Beginning of treatment in RCT a
study?
Don't know?
4 of 41
, Definition
Efficacy trials vs. Effectiveness trials
Efficacy trials = ideal environments
- Best equipment
- Best staff
- Best professionals
1. Non-compliance, less selected patients, less selected
clinicians, impracticaclity, costs = low
2.Internal validity: high
3. External validity: low
Effectiveness trials = non-ideal environments
- Ordinary circumstances
1. Non-compliance, less selected patients, less selected
clinicians, impracticaclity, costs = high
2.Internal validity: low
3. External validity: high
Give this one a try later!
Management of explanatory
trials, whats the difference Guideline 1. Was the assignment of
between an efficacy trial and patients to treatments really
a effectiveness trial? randomized?
Guideline 3. Were the study After determining the individuals
patients recognizably similar to included into the study how are the
your own? comparison groups made?
Don't know?
THERAPEUTIC TRIALS QUESTIONS WITH
100% CORRECT!!
1 of 41
Term
What does TPD stand for?
Give this one a try later!
Drugs Directorate Natural Health Products Directorate
Marketed Health Products Therapeutic Products
Directorate Directorate
, Don't know?
2 of 41
Term
What are some intervention considerations?
Give this one a try later!
1. Generalizability (standard treatment) - not patient but treatment
2.Complexity (1 or multiple treatments) - surgery, radiation, meds
3.Strength - 95/100 have have hypothyroid are successful
D+ = unhealthy
D- = healthy
T+ = Treatment
T- = placebo
P (D+ | T+) non-effective
P (D- | T+) effective
** Look at chart from lecture
1. Patient spectrum
2.Standard treatment
People need to cross over early because if they do it too late there will not be
enough data to collect on them and this data cannot be used
Don't know?
,3 of 41
Definition
Measured from having no control group
Participants are measured pre or at baseline and then measured
post
Example. they measure that they feel 20%/100% good at baseline Post
they say they feel 80%/100%
This means that the treatment have a 60% total effect!
This is used to compare to the regular treatment, if the normal
treatment total effect is 90% we wouldn't switch, however, if the total
effect was 40%, we would switch to this treatment
Give this one a try later!
What does prognostic stratification What happens if a patient switches
need to take place? from treatment to placebo group?
What is the total effect in
Beginning of treatment in RCT a
study?
Don't know?
4 of 41
, Definition
Efficacy trials vs. Effectiveness trials
Efficacy trials = ideal environments
- Best equipment
- Best staff
- Best professionals
1. Non-compliance, less selected patients, less selected
clinicians, impracticaclity, costs = low
2.Internal validity: high
3. External validity: low
Effectiveness trials = non-ideal environments
- Ordinary circumstances
1. Non-compliance, less selected patients, less selected
clinicians, impracticaclity, costs = high
2.Internal validity: low
3. External validity: high
Give this one a try later!
Management of explanatory
trials, whats the difference Guideline 1. Was the assignment of
between an efficacy trial and patients to treatments really
a effectiveness trial? randomized?
Guideline 3. Were the study After determining the individuals
patients recognizably similar to included into the study how are the
your own? comparison groups made?
Don't know?
