MIC 319 Exam 4 Exam 2025 Questions and
Answers
Extracellular pathogens can be: - ANS bacteria, viruses, fungi, parasite
opsonization = - ANS coating of bacterium with antibody and/or complement
What is the point of opsonization? - ANS To make the pathogen more readily ingested by
phagocytes
complement = - ANS collection of plasma proteins that act in a cascade of reactions to attack
extracellular forms of pathogens
cellular innate responses = - ANS neutrophil and macrophage phagocytosis
Killing of microbes by cellular processes begins when? - ANS when they make contact with
cells. This process continues within the phagolysosome.
Neutrophils are stored in the __________ - ANS bone marrow
What are the 4 stages of extravasation of neutrophils: - ANS 1. Rolling adhesion via LFA and
ICAM-1
2. Tight binding
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, 3. Diapedesis
4. Migration along CXCL8 chemokine gradient
Receptor for complement? - ANS CD4
Receptor for LPS? - ANS CD14
Molecular innate response to extracellular bacteria? - ANS complement proteins
MAC refers to - ANS complement
PF referes to - ANS perforin
Who discovered P1 and P2 - ANS Dr. Podack
The killer domain of pore forming protein is the _____ domain - ANS MACPF
Extracellular batteria are killed by - ANS complement membrane attack complex poly-C9
Virus infected cells are killed by - ANS P1
Intracellular bacteria are killed by - ANS P2
The last event of C9 is _______ - ANS making the hole in the bacteria
Size of poly C-9 pore? - ANS 110-120 A
Pg. 2 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
Answers
Extracellular pathogens can be: - ANS bacteria, viruses, fungi, parasite
opsonization = - ANS coating of bacterium with antibody and/or complement
What is the point of opsonization? - ANS To make the pathogen more readily ingested by
phagocytes
complement = - ANS collection of plasma proteins that act in a cascade of reactions to attack
extracellular forms of pathogens
cellular innate responses = - ANS neutrophil and macrophage phagocytosis
Killing of microbes by cellular processes begins when? - ANS when they make contact with
cells. This process continues within the phagolysosome.
Neutrophils are stored in the __________ - ANS bone marrow
What are the 4 stages of extravasation of neutrophils: - ANS 1. Rolling adhesion via LFA and
ICAM-1
2. Tight binding
Pg. 1 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
, 3. Diapedesis
4. Migration along CXCL8 chemokine gradient
Receptor for complement? - ANS CD4
Receptor for LPS? - ANS CD14
Molecular innate response to extracellular bacteria? - ANS complement proteins
MAC refers to - ANS complement
PF referes to - ANS perforin
Who discovered P1 and P2 - ANS Dr. Podack
The killer domain of pore forming protein is the _____ domain - ANS MACPF
Extracellular batteria are killed by - ANS complement membrane attack complex poly-C9
Virus infected cells are killed by - ANS P1
Intracellular bacteria are killed by - ANS P2
The last event of C9 is _______ - ANS making the hole in the bacteria
Size of poly C-9 pore? - ANS 110-120 A
Pg. 2 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
