BMTCN — CHAPTER 1: BASIC CONCEPTS AND INDICATIONS FOR TRANSPLANTATION, BMTCN REVIEW MANUAL CH 1-7, BMTCN REVIEW CHAPTER 2- TYPES OF TRANSPLANTS AND SOURCES OF STEM CELLS, BMTCN REVIEW CHAPTER 3 - PRETRANSPLANT ISSUES, BMTCN CH 5 - GVHD, BMTCN CHAPTER 6: P

TABLE OF CONTENT BMTCN — Chapter 1: Basic Concepts and Indications for Transplantation [ANSWERED] BMTCN review manual CH 1-7 [ANSWERED] BMTCN Review Chapter 2-Types of Transplants and Sources of Stem Cells [ANSWERED] BMTCN Review Chapter 3 - Pretransplant Issues [ANSWERED] BMTCN Ch 5 - GVHD [ANSWERED] BMTCN Chapter 6: Post-Transplant Issues [ANSWERED] BMTCN Chapter 7: Surivorship Issues [ANSWERED] BMTCN Review Chapter 8 - Professional Practice [ANSWERED] Chapter 52 – GVHD [ANSWERED] What is hematopoiesis? formation of blood cellular components Red bone marrow produces... Red blood cells, white blood cells, and platelets. Found in the long and flat bones Yellow bone marrow and fat cells produce... Fat, cartilage, and bone. Located in the long bones. Components of hematopoiesis HSC develop prior to birth, produced in long bones during childhood and axial skeleton during adulthood. •Bone marrow stroma = hub of cellular activity •Chemokines and cytokines = control proliferation and mobilization of cells Primary function of hematopoiesis Maintain peripheral blood with proper level of blood components Myeloid stem cells produce Megakaryoblast - platelets Monoblasts - dendritic cells, monocytes, macrophages Erythroblasts - erythrocytes Myeloblasts - the phils (eosinophils, neutrophils, basophils) Tissue mast cells lymphoid progenitor cells produce Lymphocytes (t lymph cells, b lymph cells - memory plasma cells) NK t cells Primary Immune System Organs Bone marrow Thymus (t cells, anterior mediastinum) Lymph nodes (immunologic filtration) Spleen (filtering WBCs, platelets, and other) Microbiome (maturation of immune response) Senescence loss of a cell's power of division and growth, occurs with age but also canxer tx and transplantation. •Immunosenescence = reduction in size of thymus and immune cell function (not decrease in number) Who are the first responders to injury and not pathogen specific? Myeloid cells Who come later in an immune response and are pathogen specific? Lymphoid cells What is high -resolution human leukocyte antigen typing used for