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N554 Exam 3 2025/2026 Exam Questions with Detailed Verified Answers (100% Correct Answers) | Already Graded A+

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N554 Exam 3 2025/2026 Exam Questions with Detailed Verified Answers (100% Correct Answers) | Already Graded A+ Systematic Approach for Selection of Antimicrobials -

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N554 Exam 3 2025/2026 Exam Questions
with Detailed Verified Answers (100%
Correct Answers) | Already Graded A+



Systematic Approach for Selection of Antimicrobials - 🧠 ANSWER

✔✔Confirm the presence of infection


Identify the pathogen

Select empiric therapy considering every infected site

Monitor therapeutic response


Hallmark for ID? - 🧠 ANSWER ✔✔FEVER


Controlled elevation of body temperature above normal range


Temp for fever - 🧠 ANSWER ✔✔> 37°C, 98.6°F


Consider APAP/NSAID mask

and drugs causing fever


How do differential WBC change with infection - 🧠 ANSWER ✔✔Total WBC

over 10,000


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,Increased NEUtrophils

DECREAsed lymphocytes

At least ___ of the 4 following signs and symptoms must be present for a

patient to meet "SIRS" criteria - 🧠 ANSWER ✔✔TWO




Temperature >38°C or <36°C

Heart rate >90 beats per minute

WBC >12,000 or <4,000 or >10% bands

Respiratory rate >20 breaths per minute


Confirming Sepsis - 🧠 ANSWER ✔✔Sepsis: life-threatening ***organ

dysfunction*** caused by a dysregulated host response to infection


Empiric therapy - 🧠 ANSWER ✔✔Best guess at causative organism and

susceptibility

No culture and susceptibility results available

Directed at organisms that are known to cause the infection




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,Definitive therapy - 🧠 ANSWER ✔✔Choosing agent after culture and

susceptibility reports available

Choose antimicrobial of choice for infection if it is susceptible and there are

no contraindications


Selection of empiric therapy HOST factors - 🧠 ANSWER ✔✔Site of

infection

**Drug allergies**

**Age** -> ADR, organ f(x), etiology

Renal and hepatic function

Concomitant drug therapy

Concomitant disease states- CF (Pseudomonas, diabetics, infection)

Pregnancy


Selection of empiric therapy DRUG factors - 🧠 ANSWER ✔✔Tissue

penetration

Pharmacokinetic and pharmacodynamics [PK-PD] considerations

T > MIC

Peak: MIC

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, AUC:MIC

Drug toxicity

Cost

Sanford Guide: Find ABX, antivirals, meds that do NOT require renal

adjustment - 🧠 ANSWER ✔✔Table 17B


azithromycin

ceftriaaxone

chloramphenicol

ciprofloaxicin

clindamycin

doxycycline

linezolid

minocycline

moxifloaxcin

nafcillin

ortiavancin



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