MIC319 Final 2025/2026 Exam Questions
with Detailed Verified Answers (100%
Correct Answers) | Already Graded A+
False on the consequence of not having NK cells
a. Easily succumb to viral infection
b. Higher incidence of cancer
c. Cell mediated killing of cells expressing high levels of MMC-I in the cell
surface
d. Impaired anti-viral innate immunity - 🧠 ANSWER ✔✔c. Cell mediated
killing of cells expressing high levels of MMC-I in the cell surface
Indicate false about evasion of the immune response by viruses
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,a. Many viruses carry mechanism to downregulate the MMC Class-! To
avoid immune recognition.
b. Evasion of the innate immune response by viruses can prevent all
disease symptoms.
c. Many pathogenic viruses carry anti-apoptotic proteins
d. Viruses have evolved mechanism to evade killing by NK cells - 🧠
ANSWER ✔✔b. Evasion of the innate immune response by viruses can
prevent all disease symptoms.
Identify the false statement about the apoptosome and it formation
a. Cytochrome C released by the mitochondria catalyzes the
oligomerization of APAF with Caspase-9 to form the apoptosome
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,b. It can be directly activated by death receptors via DISC formation and
activation of Caspase-8
c. It is a molecular killing machine that massively activates Caspase-3
d. It is antagonized by anti-apoptotic IAP proteins - 🧠 ANSWER ✔✔b. It can
be directly activated by death receptors via DISC formation and activation
of Caspase-8
Indicate False about TNF-alpha, an inflammatory cytokine that in spite of
binding a receptor containing a dead domain does not cause apoptosis in
many cell types:
a. TNF-alpha treated cells survive because TNF-alpha can't activate the
extrinsic apoptosis pathway through DISC formation
b. TNF-alpha activation of the NFKB pathway leads to transcription of the
anti apoptotic Bcl-2 member Bcl-XL and the IAP apoptosome inhibitor.
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, c. The TNF-alpha receptor activates DISC leading to caspase 8 activation
d. TNF-alpha treated cells can show cleavage of caspase 3 - 🧠 ANSWER
✔✔a. TNF-alpha treated cells survive because TNF-alpha can't activate the
extrinsic apoptosis pathway through DISC formation
Indicate the only mechanism unique to the extrinsic pathway of apoptosis
a. Death receptor recruitment of the adaptor FADD and caspase 8 with
formation of the DISC signaling complex
b. Mitochondrial release of Cytochrome C leading to apoptosome formation
c. Cleavage of pro caspase 3
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with Detailed Verified Answers (100%
Correct Answers) | Already Graded A+
False on the consequence of not having NK cells
a. Easily succumb to viral infection
b. Higher incidence of cancer
c. Cell mediated killing of cells expressing high levels of MMC-I in the cell
surface
d. Impaired anti-viral innate immunity - 🧠 ANSWER ✔✔c. Cell mediated
killing of cells expressing high levels of MMC-I in the cell surface
Indicate false about evasion of the immune response by viruses
COPYRIGHT©BLAIRALISTERNEWTON 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
1
PRIVACY STATEMENT. ALL RIGHTS RESERVED
,a. Many viruses carry mechanism to downregulate the MMC Class-! To
avoid immune recognition.
b. Evasion of the innate immune response by viruses can prevent all
disease symptoms.
c. Many pathogenic viruses carry anti-apoptotic proteins
d. Viruses have evolved mechanism to evade killing by NK cells - 🧠
ANSWER ✔✔b. Evasion of the innate immune response by viruses can
prevent all disease symptoms.
Identify the false statement about the apoptosome and it formation
a. Cytochrome C released by the mitochondria catalyzes the
oligomerization of APAF with Caspase-9 to form the apoptosome
COPYRIGHT©BLAIRALISTERNEWTON 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
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PRIVACY STATEMENT. ALL RIGHTS RESERVED
,b. It can be directly activated by death receptors via DISC formation and
activation of Caspase-8
c. It is a molecular killing machine that massively activates Caspase-3
d. It is antagonized by anti-apoptotic IAP proteins - 🧠 ANSWER ✔✔b. It can
be directly activated by death receptors via DISC formation and activation
of Caspase-8
Indicate False about TNF-alpha, an inflammatory cytokine that in spite of
binding a receptor containing a dead domain does not cause apoptosis in
many cell types:
a. TNF-alpha treated cells survive because TNF-alpha can't activate the
extrinsic apoptosis pathway through DISC formation
b. TNF-alpha activation of the NFKB pathway leads to transcription of the
anti apoptotic Bcl-2 member Bcl-XL and the IAP apoptosome inhibitor.
COPYRIGHT©BLAIRALISTERNEWTON 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
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PRIVACY STATEMENT. ALL RIGHTS RESERVED
, c. The TNF-alpha receptor activates DISC leading to caspase 8 activation
d. TNF-alpha treated cells can show cleavage of caspase 3 - 🧠 ANSWER
✔✔a. TNF-alpha treated cells survive because TNF-alpha can't activate the
extrinsic apoptosis pathway through DISC formation
Indicate the only mechanism unique to the extrinsic pathway of apoptosis
a. Death receptor recruitment of the adaptor FADD and caspase 8 with
formation of the DISC signaling complex
b. Mitochondrial release of Cytochrome C leading to apoptosome formation
c. Cleavage of pro caspase 3
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