MGRADES
Walden 6630 Psychopharmacology Midterm
Study Guide UPDATED ACTUAL Exam
Questions and CORRECT Answers
Serotonin regulates - CORRECT ANSWER - Mood, emotion, feeding, and reproductive
behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of
serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors -
CORRECT ANSWER - SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT ANSWER -
SSRIs
Six Common SSRIs - CORRECT ANSWER - citalopram, escitalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT ANSWER - 4-6 weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWER - Chronic Anxiety, PTSD,
OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include - CORRECT ANSWER - Anxiety, insomnia,
GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - CORRECT
ANSWER - suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other
serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - CORRECT ANSWER - Serotonin
Syndrome
,MGRADES
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
CORRECT ANSWER - Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWER - Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome - CORRECT ANSWER - Cyproheptadine (5-HT2
receptor antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWER - blocking 5-HT2
receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
CORRECT ANSWER - Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - CORRECT ANSWER - Prolonged QT
interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
CORRECT ANSWER - Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT ANSWER -C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT ANSWER -
fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWER - duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
, MGRADES
This antidepressant class of medications works by binding to presynaptic SERT and NET to
inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the
synaptic cleft - CORRECT ANSWER - SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWER - Anxiety and neuropathic pain
(peripheral neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWER - urinary
incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWER - social anxiety,
panic disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - CORRECT ANSWER - Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - CORRECT
ANSWER - suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other
serotonergic drugs: - CORRECT ANSWER - Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - CORRECT ANSWER -
venlafaxine
This SNRI is hepatotoxic: - CORRECT ANSWER - duloxetine
MAOIs increase the levels of: - CORRECT ANSWER - Serotonin, Norepinephrine, and
Dopamine
Norepinephrine regulates: - CORRECT ANSWER - alertness and focus
Walden 6630 Psychopharmacology Midterm
Study Guide UPDATED ACTUAL Exam
Questions and CORRECT Answers
Serotonin regulates - CORRECT ANSWER - Mood, emotion, feeding, and reproductive
behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of
serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors -
CORRECT ANSWER - SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT ANSWER -
SSRIs
Six Common SSRIs - CORRECT ANSWER - citalopram, escitalopram, fluoxetine,
fluvoxamine, sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT ANSWER - 4-6 weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWER - Chronic Anxiety, PTSD,
OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include - CORRECT ANSWER - Anxiety, insomnia,
GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - CORRECT
ANSWER - suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other
serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - CORRECT ANSWER - Serotonin
Syndrome
,MGRADES
Excess accumulation of serotonin resulting in overstimulation of the nervous system -
CORRECT ANSWER - Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWER - Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome - CORRECT ANSWER - Cyproheptadine (5-HT2
receptor antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWER - blocking 5-HT2
receptors (serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
CORRECT ANSWER - Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - CORRECT ANSWER - Prolonged QT
interval (normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects -
CORRECT ANSWER - Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT ANSWER -C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT ANSWER -
fluoxetine, fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWER - duloxetine, venlafaxine,
desvenlafaxine, milnacipran, levomilnacipran
, MGRADES
This antidepressant class of medications works by binding to presynaptic SERT and NET to
inhibit them from reuptake of serotonin and norepinephrine to increase their levels in the
synaptic cleft - CORRECT ANSWER - SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWER - Anxiety and neuropathic pain
(peripheral neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWER - urinary
incontinence and Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWER - social anxiety,
panic disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - CORRECT ANSWER - Insomnia, nausea,
sexual dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - CORRECT
ANSWER - suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other
serotonergic drugs: - CORRECT ANSWER - Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - CORRECT ANSWER -
venlafaxine
This SNRI is hepatotoxic: - CORRECT ANSWER - duloxetine
MAOIs increase the levels of: - CORRECT ANSWER - Serotonin, Norepinephrine, and
Dopamine
Norepinephrine regulates: - CORRECT ANSWER - alertness and focus
