Gms 6552 Exam With 100- Correct Answers

GMS 6552 EXAM WITH 100% CORRECT
ANSWERS


Most common drug target - CORRECT ANSWERS ✔✔- receptors
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Channel-linked receptors - CORRECT ANSWERS ✔✔- ion channels open when
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bound to ligand
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- hyperpolarization or depolarization
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- milliseconds
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- ex. nicotinic receptor, ACh receptor
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G-protein coupled receptors - CORRECT ANSWERS ✔✔- use second
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messenger systems to induce cellular effects when bound
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- seconds
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- ex. muscarinic ACh receptor
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Kinase-linked receptors - CORRECT ANSWERS ✔✔- cause protein
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phosphorylation inducing cellular effects when bound
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-minutes
- ex. insulin receptor
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Nuclear receptors - CORRECT ANSWERS ✔✔- induce gene transcription when
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bound
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,- hours
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- ex. estrogen receptor
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Heterotrimeric G proteins - CORRECT ANSWERS ✔✔- receptor \/| \/| \/| \/| \/| \/| \/|




- alpha, beta, gamma - subunits
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- amplify signal
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- induce second messenger systems
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Alpha subunit - CORRECT ANSWERS ✔✔- binds GTP converting to GDP
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GPCR ligands - CORRECT ANSWERS ✔✔- hormones
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- neurotransmitters
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- chemokines
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- ions
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- amino acids
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- peptides
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- etc.
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PKA - CORRECT ANSWERS ✔✔- protein kinase A
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- activated by cyclic AMP
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- enter nucleus and alter transcription
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Phosphorylase kinase - CORRECT ANSWERS ✔✔- activated by PKA \/| \/| \/| \/| \/| \/| \/| \/|

, - breakdown glycogen
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L-type Ca Channels - CORRECT ANSWERS ✔✔- activated by PKA
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- heart contraction
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Pyruvated kinase - CORRECT ANSWERS ✔✔- activated by PKA
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- activate gylcolysis
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Hormone sensitve lipase - CORRECT ANSWERS ✔✔- activated by PKA
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- cause triglyceride breakdown
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CREB - CORRECT ANSWERS ✔✔- activated by PKA
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- cause gene transcription
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Adenylate cyclase - CORRECT ANSWERS ✔✔- activated by GPCR
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- cAMP as second messenger
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- activate PKA
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Phosphollipase C - CORRECT ANSWERS ✔✔- activated by GPCR \/| \/| \/| \/| \/| \/| \/| \/|




- IP3 as second messenger
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- increase Ca2+ causing contraction
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Phospholipase A2 - CORRECT ANSWERS ✔✔- activated by GPCR \/| \/| \/| \/| \/| \/| \/| \/|