1|Page
JACI PRIMER EXAM LATEST 2025 ACTUAL EXAM WITH COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS (100% VERIFIED
ANSWERS) |ALREADY GRADED A+| ||PROFESSOR VERIFIED||
||BRANDNEW!!!||
Question 1. Which of the following statements concerning severe
combined immunodeficiency (SCID) is true?
A. SCID is characterized by severe deficiency of T cells.
B. SCID is characterized by severe deficiency of T and B cells.
C. SCID is characterized by severe deficiency of T, B, and natural
killer cells.
D. SCID is characterized by severe deficiency of both
lymphocytes and neutrophils. - ANSWER-1. Answer: A
Explanation: SCID includes a heterogeneous group of
disorders characterized by severe defects in T-cell
development. Some (but not all) forms of SCID also have
defects in B-cell development, natural killer cell
development, or both, whereas impaired myeloid
differentiation is restricted to a few rare forms of SCID.
Regardless of the presence or absence of B cells, patients
with SCID have a severe defect in antibody production,
reflecting a lack of T lymphocytes.
,2|Page
Question 2. Which of the following statements concerning X-
linked agammaglobulinemia (XLA) is true?
A. XLA is characterized by lack of immunoglobulins in spite of a
normal number of circulating B cells.
B. XLA is characterized by a virtual lack of circulating B cells.
C. In patients with XLA, the profound deficiency of
immunoglobulins reflects defects of TH lymphocytes.
D. The mainstay of treatment of patients with XLA is antibiotic
prophylaxis. - ANSWER-2. Answer: B
Explanation: XLA and all other forms of congenital
agammaglobulinemia are caused by genetic defects that
affect signaling through the pre-B-cell receptor in the bone
marrow. Therefore patients with congenital
agammaglobulinemia typically lack circulating mature B
cells.
Question 3. Which of the following presentations is common in
patients with chronic granulomatous disease?
A. autoimmune manifestations resembling systemic lupus
erythematosus
B. interstitial pneumonia caused by Pneumocystis jiroveci
,3|Page
C. purulent lymphadenitis
D. recurrent otitis media - ANSWER-3. Answer: C
Explanation: Neutrophils are important in the defense
against bacteria and fungi. Patients with neutrophil defects
often present with severe infections, among which purulent
lymphadenitis is common.
Question 4. Which of the following statements concerning treat-
ment with immunoglobulins is true?
A. Initial treatment for patients with agammaglobulinemia should
be with intravenous immunoglobulin, 100 mg/kg every 3 weeks.
B. Subcutaneous immunoglobulins should be used at the dose of
100 mg/kg/wk in children less than 14 years of age. Beyond that
age, the dose for adults is 4 g/wk.
C. The usual dose for subcutaneous immunoglobulins is 100
mg/kg/wk.
D. Patients with IgA deficiency should receive preparations
enriched in IgA. - ANSWER-4. Answer: C
Explanation: It is important that patients with antibody
deficiency receive appropriate replacement treatment. This is
usually achieved with 400 mg/kg/mo intravenous
, 4|Page
immunoglobulins or with weekly injections of subcutaneous
immunoglobulins at a dose of 100 mg/kg/ wk. This regimen
applies to patients of any age.
Question 1. An 18-year-old woman presents with a history of
recurrent respiratory tract infections in the past 3 months. She has
been previously healthy. Which of the following is the most likely
cause of immunodeficiency in this patient?
A. severe combined immunodeficiency
B. HIV infection
C. X-linked agammaglobulinemia
D. hyper-IgM syndrome - ANSWER-1. Answer: B
Explanation: From the 4 options, option B is the most likely
answer. HIV infection can be considered as a cause of
immunodeficiency at any age. Options A, C, and D are
primary immunodeficiencies that present clinically in infancy
or early childhood.
Question 2. Which of the following is a characteristic of a sec-
ondary immunodeficiency?
JACI PRIMER EXAM LATEST 2025 ACTUAL EXAM WITH COMPLETE
QUESTIONS AND CORRECT DETAILED ANSWERS (100% VERIFIED
ANSWERS) |ALREADY GRADED A+| ||PROFESSOR VERIFIED||
||BRANDNEW!!!||
Question 1. Which of the following statements concerning severe
combined immunodeficiency (SCID) is true?
A. SCID is characterized by severe deficiency of T cells.
B. SCID is characterized by severe deficiency of T and B cells.
C. SCID is characterized by severe deficiency of T, B, and natural
killer cells.
D. SCID is characterized by severe deficiency of both
lymphocytes and neutrophils. - ANSWER-1. Answer: A
Explanation: SCID includes a heterogeneous group of
disorders characterized by severe defects in T-cell
development. Some (but not all) forms of SCID also have
defects in B-cell development, natural killer cell
development, or both, whereas impaired myeloid
differentiation is restricted to a few rare forms of SCID.
Regardless of the presence or absence of B cells, patients
with SCID have a severe defect in antibody production,
reflecting a lack of T lymphocytes.
,2|Page
Question 2. Which of the following statements concerning X-
linked agammaglobulinemia (XLA) is true?
A. XLA is characterized by lack of immunoglobulins in spite of a
normal number of circulating B cells.
B. XLA is characterized by a virtual lack of circulating B cells.
C. In patients with XLA, the profound deficiency of
immunoglobulins reflects defects of TH lymphocytes.
D. The mainstay of treatment of patients with XLA is antibiotic
prophylaxis. - ANSWER-2. Answer: B
Explanation: XLA and all other forms of congenital
agammaglobulinemia are caused by genetic defects that
affect signaling through the pre-B-cell receptor in the bone
marrow. Therefore patients with congenital
agammaglobulinemia typically lack circulating mature B
cells.
Question 3. Which of the following presentations is common in
patients with chronic granulomatous disease?
A. autoimmune manifestations resembling systemic lupus
erythematosus
B. interstitial pneumonia caused by Pneumocystis jiroveci
,3|Page
C. purulent lymphadenitis
D. recurrent otitis media - ANSWER-3. Answer: C
Explanation: Neutrophils are important in the defense
against bacteria and fungi. Patients with neutrophil defects
often present with severe infections, among which purulent
lymphadenitis is common.
Question 4. Which of the following statements concerning treat-
ment with immunoglobulins is true?
A. Initial treatment for patients with agammaglobulinemia should
be with intravenous immunoglobulin, 100 mg/kg every 3 weeks.
B. Subcutaneous immunoglobulins should be used at the dose of
100 mg/kg/wk in children less than 14 years of age. Beyond that
age, the dose for adults is 4 g/wk.
C. The usual dose for subcutaneous immunoglobulins is 100
mg/kg/wk.
D. Patients with IgA deficiency should receive preparations
enriched in IgA. - ANSWER-4. Answer: C
Explanation: It is important that patients with antibody
deficiency receive appropriate replacement treatment. This is
usually achieved with 400 mg/kg/mo intravenous
, 4|Page
immunoglobulins or with weekly injections of subcutaneous
immunoglobulins at a dose of 100 mg/kg/ wk. This regimen
applies to patients of any age.
Question 1. An 18-year-old woman presents with a history of
recurrent respiratory tract infections in the past 3 months. She has
been previously healthy. Which of the following is the most likely
cause of immunodeficiency in this patient?
A. severe combined immunodeficiency
B. HIV infection
C. X-linked agammaglobulinemia
D. hyper-IgM syndrome - ANSWER-1. Answer: B
Explanation: From the 4 options, option B is the most likely
answer. HIV infection can be considered as a cause of
immunodeficiency at any age. Options A, C, and D are
primary immunodeficiencies that present clinically in infancy
or early childhood.
Question 2. Which of the following is a characteristic of a sec-
ondary immunodeficiency?
