Questions and Answers 100% Pass
Pharmacodynamics - ✔✔How a drug affects the body
Receptors - ✔✔Large molecules that interact with and mediate the action of drugs
Up-regulation - ✔✔Increases the number of receptors; if an antagonist causes this can
get rebound effects if the drug is abruptly withdrawn
Down-regulation - ✔✔Decreases the number of receptors; if an agonist causes this can
limit the length of time the patient can take the drug
Agonists - ✔✔Activators; stimulates receptors.
Promotes normal function of the protein (receptor).
Antagonists - ✔✔Blockers; occupy receptors without stimulating them, prevent other
molecules from occupying that site.
Silences the protein and prevents function.
Beers Criteria - ✔✔List of potentially inappropriate medications that are best avoided
by older adults in most circumstances or with specific disease or conditions
Partial agonists - ✔✔Bind to receptors but stimulate only some of them, can help
prevent too extreme of a response
Therapeutic index - ✔✔Ratio of dose that causes ADRs to therapeutic dose, safer to
have a wide range than a narrow range
Prodrugs - ✔✔L-Dopa, codeine, hydrocodone, meperidine; inactive compounds that
rely on metabolism to become active
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