Peptic Ulcer Disease (PUD) Exam 2025
Questions and Answers 100% Pass
PUD - ✔✔A condition characterized by mucosal defects ≥5 mm in the stomach or
duodenum that penetrate the muscularis mucosa.
H. pylori infection, NSAID use, and stress-related mucosal damage (SRMD). -
✔✔What are the 3 major causes of PUD?
Imbalance between aggressive factors (acid, pepsin, H. pylori, NSAIDs) and
protective factors (mucus, bicarbonate, blood flow, prostaglandins) - ✔✔What is the
primary mechanism behind PUD development?
It produces urease, which neutralizes stomach acid by converting urea to ammonia -
✔✔How does H. pylori survive in the stomach?
It induces inflammation, disrupts the mucosal barrier, and increases acid secretion -
✔✔How does H. pylori cause ulcers?
Urease, catalase, and oxidase - ✔✔What enzyme activities does H. pylori possess?
In the duodenum - ✔✔Where are H. pylori-induced ulcers most commonly found?
By inhibiting COX-1, reducing prostaglandins that protect the mucosa - ✔✔How do
NSAIDs cause ulcers?
Gastric ulcers - ✔✔Which type of ulcers are more common with NSAID use?
Stress-related mucosal damage occurs in critically ill patients due to mucosal
ischemia - ✔✔What is SRMD and who is at risk?
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 1
Questions and Answers 100% Pass
PUD - ✔✔A condition characterized by mucosal defects ≥5 mm in the stomach or
duodenum that penetrate the muscularis mucosa.
H. pylori infection, NSAID use, and stress-related mucosal damage (SRMD). -
✔✔What are the 3 major causes of PUD?
Imbalance between aggressive factors (acid, pepsin, H. pylori, NSAIDs) and
protective factors (mucus, bicarbonate, blood flow, prostaglandins) - ✔✔What is the
primary mechanism behind PUD development?
It produces urease, which neutralizes stomach acid by converting urea to ammonia -
✔✔How does H. pylori survive in the stomach?
It induces inflammation, disrupts the mucosal barrier, and increases acid secretion -
✔✔How does H. pylori cause ulcers?
Urease, catalase, and oxidase - ✔✔What enzyme activities does H. pylori possess?
In the duodenum - ✔✔Where are H. pylori-induced ulcers most commonly found?
By inhibiting COX-1, reducing prostaglandins that protect the mucosa - ✔✔How do
NSAIDs cause ulcers?
Gastric ulcers - ✔✔Which type of ulcers are more common with NSAID use?
Stress-related mucosal damage occurs in critically ill patients due to mucosal
ischemia - ✔✔What is SRMD and who is at risk?
COPYRIGHT © 2025 BY EMILLY CHARLOTTE, ALL RIGHTS RESERVED 1
