ONS/ONCC Chemotherapy Immunotherapy
Certificate / Actual Complete Accurate Quizzes
with Verified Answers / 2025-2026
Terms in this set (135)
Table of content
Lesson 1: Foundations to Set the Stage
Lesson 2: Alkylating Agents
Lesson 7: Cumulative Dose
Lesson 11: Targeted Therapy
Lesson 12: Immunotherapy
Lesson 13: Safe Handling
, Lesson 1: Foundations to
Set the Stage
Focusing on Cellular
Structure and Function
Restriction Point -The transition from the resting phase into an actively dividing
phase (G0-G1) is a point where cellular transformation can occur
-During this time, cells pass through a transition phase known as a
restriction point
-Extracellular growth factors trigger reentry into G1, and
GF are required to send the cells past the restriction
point, or the point of no return
G0 Phase (resting phase) -After mitosis, cells may enter back into the G1 phase or go
into a resting phase, known as G0
-Most cells in the human body reside in G0
-Exceptions to this are -Exceptions to this are those that are metabollically active, such
those that are (Resting in as
G0 phase)
-granulocytes
-and the epithelium of the GI tract
Cell Cycling Time Amount of time from mitosis to mitosis
http://highered.mheducation.com/sites/0072495855/s
Cell cycle video and image tudent_view0/chapter2/animation__how_the_cell_cycle_
works.html
, Check points in the Cell -The cell cycle is carefully controlled through a series of
Cycle: Keeping it All checkpoints
Under Control
-Variation in duplication or distribution of chromosomes
during cell division can alter the genetic information passed
on to daughter cells, leading to cellular dysfunction and
disease, such as cancer
-These checkpoints monitor for DNA integrity and control
progression through mitosis
Progression through the 1. cyclines (D, E, A, B)
cell cycle is controlled
through two proteins:
2. Cyclin-dependent kinases (CDKs)
-Cyclin-CDK complex allows the cell to progress through each
phase of the cell cycle
Locations of proteins -(G0-G1) : Cyclin D and CDK 4/6
Cyclins (D, E, A, B) and
CDKs -Early S: Cyclin E and CDK 1/2
-Late S: Cyclin A and CDK 1/2
-G2: CDK 1/2 and cyclin A
-Before M: CDK 1 and Cyclin B
-prevent progression of the cycle when DNA damage is
detected
Inhibitory proteins
-An example of an inhibitory protein is p53 (AKA
TP53)
Certificate / Actual Complete Accurate Quizzes
with Verified Answers / 2025-2026
Terms in this set (135)
Table of content
Lesson 1: Foundations to Set the Stage
Lesson 2: Alkylating Agents
Lesson 7: Cumulative Dose
Lesson 11: Targeted Therapy
Lesson 12: Immunotherapy
Lesson 13: Safe Handling
, Lesson 1: Foundations to
Set the Stage
Focusing on Cellular
Structure and Function
Restriction Point -The transition from the resting phase into an actively dividing
phase (G0-G1) is a point where cellular transformation can occur
-During this time, cells pass through a transition phase known as a
restriction point
-Extracellular growth factors trigger reentry into G1, and
GF are required to send the cells past the restriction
point, or the point of no return
G0 Phase (resting phase) -After mitosis, cells may enter back into the G1 phase or go
into a resting phase, known as G0
-Most cells in the human body reside in G0
-Exceptions to this are -Exceptions to this are those that are metabollically active, such
those that are (Resting in as
G0 phase)
-granulocytes
-and the epithelium of the GI tract
Cell Cycling Time Amount of time from mitosis to mitosis
http://highered.mheducation.com/sites/0072495855/s
Cell cycle video and image tudent_view0/chapter2/animation__how_the_cell_cycle_
works.html
, Check points in the Cell -The cell cycle is carefully controlled through a series of
Cycle: Keeping it All checkpoints
Under Control
-Variation in duplication or distribution of chromosomes
during cell division can alter the genetic information passed
on to daughter cells, leading to cellular dysfunction and
disease, such as cancer
-These checkpoints monitor for DNA integrity and control
progression through mitosis
Progression through the 1. cyclines (D, E, A, B)
cell cycle is controlled
through two proteins:
2. Cyclin-dependent kinases (CDKs)
-Cyclin-CDK complex allows the cell to progress through each
phase of the cell cycle
Locations of proteins -(G0-G1) : Cyclin D and CDK 4/6
Cyclins (D, E, A, B) and
CDKs -Early S: Cyclin E and CDK 1/2
-Late S: Cyclin A and CDK 1/2
-G2: CDK 1/2 and cyclin A
-Before M: CDK 1 and Cyclin B
-prevent progression of the cycle when DNA damage is
detected
Inhibitory proteins
-An example of an inhibitory protein is p53 (AKA
TP53)
