PHARMACOLOOGY, TOXICOLOGY, PHARMACOKINETICS
PHARMACOLOGY, TOXICOLOGY, PHARMACOKINETICS
Two dose-response curve response plotted on the same graph showed sigmoid curves having the same
slope and height. T curve is located to the right of the A curve. Which of the following statements
is/are correct regarding curves A an:
A is more effective than B
A is more potent than B
A and B have the same ceiling dose
B is the graph produced when A is given with its competitive antagonist
B is the graph produced when A is given with its non-competitive antagonist
Only I and III are correct
Only II, III and IV are correct
Only II and IV are correct
Only III and V are correct
Only V is correct
Two dose-response curve plotted on the same graph showed sigmoid curves A and B, where A is at the
left of the graph with the height greater than B. Which of the following statements is/are correct
regarding curves A and B?
A and B has equal efficacy
A and B have equal potency
B is a partial agonist of A
B is the graph produced when A is given with its competitive antagonist
B is the graph produced when A is given with its non-competitive antagonist
,Only I and III are correct
Only II, III and IV are correct
Only II and IV are correct
Only III and V are correct
Only V is correct
The cumulative number of subjects who display a certain rersponse or effect to a drug is plotted on a
graph as shown below. The graph on the left represents beneficial effect while the graph on the
right represents toxic effect, what is the therapeutic index of the drug?
a.0.5 b. 1.5 c. 2.5 d.4.0 e. 5.0
An administration of one drug leads to a shift in the log dose-response curve of another drug to the left
a range in the maximal efficacy, this is called
Agonism
Partial agonism
Non-competitive antagonism
Competitive antagonism
Potentiation
The action of this drug is dependent on a colligative property
Mannitol
Cocaine
Reserpine
Furosemide
Losartan
Whiich of the following drug groups have mechanisms of aaction that involve binding to enzymes as
target protiens
Benzodiazepines
Barbiturates
Calcium channel blockers
Non-steroidal anti-inflammatory agents
Phenothiazine antipsychotics
Voltage-gated ion channels serve as site of actions for drugs such as
Diltiazem and Nifedipine
Lidocaine and Procaine
Captopril and Losartan
I only
I and II
III only
, a. I #Eand #EIII
b. I, #EII, #Eand #EIII
2. Drugs #Ewith #Emechanism #Eof #Eaction #Ethat #Einvolves #ETubulin-binding #Eleading #Eto #Eloss #Eof #Efunction #Eof
#Ethe #Estructural #Eprotien #Einclude
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
3. What #Etype #Eof #Eprotien #Eis #Eprimarily #Etargeted #Eby #EDigitalis #Eglycosides #Ewhen #Ethey #Eexert #Etheir #Eeffect
#Eon #Ethe #Eheart?
a. Receptors
b. Ion #Echannels
c. Enzymes
d. Transporters
e. Structural #Eprotiens
4. Which #Eof #Ethe #Efollowing #Efeatures #Ecahracterize #Enicotinic, #EGABA-A, #Eand #EGlutamate #Ereceptors?
a. Thay #Econtrol #Ethe #Emovements #Eof #Eions #Eand #Eout #Eof #Ethe #Ecell
b. Their #Eaction #Eis #Emediated #Ebysecondary #Emessengers
c. They #Eall #Ehave #Eexcitatory #Eeffect #Eon #Ethe #Ecell #Emembrane
d. They #Eare #Elocated #Eon #Ethe #Ecytoplasm
5. Which #Eof #Ethe #Efollowing #Edrugs #Ebind #Eto #Ereceptors #Elocated #Eat #Ethe #Ecell #Emembrane?
a. Thyroid #Ehormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin #ED
6. Cyclic #EAdenosine #EMonophophate #E(cAMP) #Eis #Egenerated #Eas #Ea #Esecondary #Emessenger #Eby #Ethe
#Eaction #Eof #Ethe #Eenzyme #EAdenylyl #ECyclase. #EThe #Esubstrate #Efor #Ethe #Esynthesis #Eof #EcAMP #Eis
a. AMD
b. ADP
c. ATP
d. GTP
e. Adenosine
7. Stimulation #Eof #EBeta-adrenoceptor, #Ea #EG-protien-linked #Ereceptor #Einvolves #Ea #Egeneration #Eof #Ea
#Esecondary #Emessenger #Eknown #Eas
a. IP3
b. cGTP
c. DAG
d. cAMP
e. Calcium #Eions
8. What #Eis #Ethe #Emechanism #Eof #Eaction #Eof #ESildenafil, #Ea #Edrug #Epopularly #Eknown #Eas #Eviagra?
a. Inhibits #Ephosphodiesterase #E(PDE) #Eleading #Eto #Eincrease #EcAMP
b. Inhibits #EPDE #Eleading #Eto #Eincrease #EcGMP
c. Stimulates #Eadenylyl #Ecyclase #Eleading #Eto #Eincrease #EcAMP
d. Stimulates #Eguanylyl #Ecyclase #Eleading #Eto #Eincrease #EcGMP
e. Inhibits #Ephosphodiesterase #Eleading #Eto #Eincrease #EcGMP
9. Drugs #Ethat #Eactivate #Ethe #Ephospholipase #EC-inositol #Ephosphate #Esystem #Esuch #Eas #Ealpha-adrenergic
#Eagonists #Elike #Ephenylephrine #Eprimarily #Ecause #Ean #Eincrease #Ein #Ethe #Eintracellular #Elevels #Eof #Ewhich
#Eion?
a. Calcium
, b. Magnesium
c. Sodium
d. Potassium
e. Chloride
10. Which #Eof #Ethe #Efollowing #Estetements #Echaracterizes #Ecompetitive #Eantagonism?
a. There #Eis #Ea #Eshift #Eof #Ethe # E agonist #Elog #Econcentration-effect #Ecurve #Eto #Ethe #Eright #Eand
#Edownwards
b. There #Eis #Ea #Eshift #Eof #Ethe #Eagonist #Elog #Econcentration-effect #Ecurve #Eto #Ethe #Eright #Ewithout #Ea
#Echange #Eon #Ethe #Eslope #Eor #Eamplitude
c. There #Eis #Ean #Eexponential #Erelationship #Ebetween #Edose #Eratio #Eand #Eantagonist #Econcentration
d. There #Eis #Eno #Ecompetition #Efor #Ethe #Ebinding #Esites
e. There #Eis #Ea #Eshift #Eof #Ethe #Eagonist #Elog-concentration #Eeffect #Ecurve #Eto #Ethe #Eleft #Ewithout #Ea
#Echange #Ein #Eslope #Eand #Eamplitude
11. The #Eminimum #Edose #Ethat #Eproduces #Ethe #Emaximum #Eachievable #Eresponse #Eis #Eknown #Eas
a. Potency
b. ED50
c. LD50
d. Ceiling #Edose
e. Minimum #Eeffective #Edose
12. The #Emedium #Edose, #Eor #Ethe #Edose #Eof #Ethe #Edrug #Ethat #Eproduces #Ehalf #Eof #Ethe #Emaximum #Eachievable
#Eresponse #Eis #Ecalled
a. Potency d. #ECeiling #Edose
b. LD50 e. #EBinding #Econstant
c. Therapeutic #Eindex
13. What #Eis #Edescribed #Eby #Ethe #Eequation #Egiven #Eas
#Efollows: #EResponse=f #E(EN #Etotal # E . # E Xa
# E / #E(Xa # E + #EKa)
a. Relationship #Ebetween #Eoccupancy #Eof #Ereceptor #Eand #Ethe #Edose #Eof #Ethe #Edrug
b. Relationship #Ebetween #Eoccupancy #Eof #Ereceptor #Eand #Eresponse #Eto #Ethe #Edrug
c. Relationship #Ebetween #Ethe #Edose #Eof #Ethe #Edrug #Eand #Ethe #Eresponse #Eto #Ethe #Edrug
d. Relationship #Ebetween #Ethe #Enumber #Eof #Ereceptors #Eand #Ethe #Edose #Eof #Ethe #Edrug
e. Relationship #Ebetween #Ethe #Eresponse #Eto #Ethe #Edrug #Eand #Ethe #Etransducer #Efunction #Eof #Ethe
#Etissues
14. Competitive #Eantagonist #Eof #Ethe #Ereceptors #Eof #EDopamine #Eand #EBenzodiazepine #Eare #Eexpected #Eto
#Eproduced #Ewhich #Eeffect?
a. Reversal #Eof #Ethe #Eintrinsic #Eactivity #Eof #Ethe #Ereceptors
b. Maintain #Ethe #Econsitutive #Eactivity #Eof #Ethe #Ereceptors
c. Stimulate #Ethe #Econstitutive #Eactivity #Eof #Ethe #Ereceptors
d. Stimulate #Ethe #Econstitutive #Eactivity #Eof #Ethe #Erecptorsin #Ethe #Eabsence #Eof #Eany #Eligand
e. Produce #Ea #Enegative #Eefficacy
15. The #EPT-INR #Eof #Ea #Epatient #Ewith #EWarfarin #Ehas #Ebeen #Emaintained #Eat #E2.5 #Efor #Ethe #Elast #E3 #Emonths. #E1
#Eweek #Eearlier, #Ethe #Epatient #Ewas #Egiven #EPhenobarbital. #EWhat #Ecan #Ebe #Eexpected #Ewith #Ethe #EPT-INR
#Eof #Ethe #Epatient?
a. Increased #EPT-INR
b. Decreased #EPT-INR
c. Maintained #EPT-INR
16. Phenobarbital #Ewhen #Egiven #Eto #Ea #Epatient #Eon #Echronic #Ewarfarin #Eis #Eclassified #Eas
a. Pharmacodynamic #E antagonist
b. Pharmacokinetic # E antagonist
c. Physiologic #Eantagonist
d. Synergistic #Eagonist
e. Additive #Eagonist
17. Digibind #Ewhich #Eeffetively #Eterminates #Ethe #Eaction #Eof #EDigitalis #Eglycosides #Eis #Eclassified #Eas
PHARMACOLOGY, TOXICOLOGY, PHARMACOKINETICS
Two dose-response curve response plotted on the same graph showed sigmoid curves having the same
slope and height. T curve is located to the right of the A curve. Which of the following statements
is/are correct regarding curves A an:
A is more effective than B
A is more potent than B
A and B have the same ceiling dose
B is the graph produced when A is given with its competitive antagonist
B is the graph produced when A is given with its non-competitive antagonist
Only I and III are correct
Only II, III and IV are correct
Only II and IV are correct
Only III and V are correct
Only V is correct
Two dose-response curve plotted on the same graph showed sigmoid curves A and B, where A is at the
left of the graph with the height greater than B. Which of the following statements is/are correct
regarding curves A and B?
A and B has equal efficacy
A and B have equal potency
B is a partial agonist of A
B is the graph produced when A is given with its competitive antagonist
B is the graph produced when A is given with its non-competitive antagonist
,Only I and III are correct
Only II, III and IV are correct
Only II and IV are correct
Only III and V are correct
Only V is correct
The cumulative number of subjects who display a certain rersponse or effect to a drug is plotted on a
graph as shown below. The graph on the left represents beneficial effect while the graph on the
right represents toxic effect, what is the therapeutic index of the drug?
a.0.5 b. 1.5 c. 2.5 d.4.0 e. 5.0
An administration of one drug leads to a shift in the log dose-response curve of another drug to the left
a range in the maximal efficacy, this is called
Agonism
Partial agonism
Non-competitive antagonism
Competitive antagonism
Potentiation
The action of this drug is dependent on a colligative property
Mannitol
Cocaine
Reserpine
Furosemide
Losartan
Whiich of the following drug groups have mechanisms of aaction that involve binding to enzymes as
target protiens
Benzodiazepines
Barbiturates
Calcium channel blockers
Non-steroidal anti-inflammatory agents
Phenothiazine antipsychotics
Voltage-gated ion channels serve as site of actions for drugs such as
Diltiazem and Nifedipine
Lidocaine and Procaine
Captopril and Losartan
I only
I and II
III only
, a. I #Eand #EIII
b. I, #EII, #Eand #EIII
2. Drugs #Ewith #Emechanism #Eof #Eaction #Ethat #Einvolves #ETubulin-binding #Eleading #Eto #Eloss #Eof #Efunction #Eof
#Ethe #Estructural #Eprotien #Einclude
a. Cyclosporine
b. Neostigmine
c. Colchicine
d. Glibenclamide
e. Metformin
3. What #Etype #Eof #Eprotien #Eis #Eprimarily #Etargeted #Eby #EDigitalis #Eglycosides #Ewhen #Ethey #Eexert #Etheir #Eeffect
#Eon #Ethe #Eheart?
a. Receptors
b. Ion #Echannels
c. Enzymes
d. Transporters
e. Structural #Eprotiens
4. Which #Eof #Ethe #Efollowing #Efeatures #Ecahracterize #Enicotinic, #EGABA-A, #Eand #EGlutamate #Ereceptors?
a. Thay #Econtrol #Ethe #Emovements #Eof #Eions #Eand #Eout #Eof #Ethe #Ecell
b. Their #Eaction #Eis #Emediated #Ebysecondary #Emessengers
c. They #Eall #Ehave #Eexcitatory #Eeffect #Eon #Ethe #Ecell #Emembrane
d. They #Eare #Elocated #Eon #Ethe #Ecytoplasm
5. Which #Eof #Ethe #Efollowing #Edrugs #Ebind #Eto #Ereceptors #Elocated #Eat #Ethe #Ecell #Emembrane?
a. Thyroid #Ehormone
b. Prednisone
c. Estrogen
d. Insulin
e. Vitamin #ED
6. Cyclic #EAdenosine #EMonophophate #E(cAMP) #Eis #Egenerated #Eas #Ea #Esecondary #Emessenger #Eby #Ethe
#Eaction #Eof #Ethe #Eenzyme #EAdenylyl #ECyclase. #EThe #Esubstrate #Efor #Ethe #Esynthesis #Eof #EcAMP #Eis
a. AMD
b. ADP
c. ATP
d. GTP
e. Adenosine
7. Stimulation #Eof #EBeta-adrenoceptor, #Ea #EG-protien-linked #Ereceptor #Einvolves #Ea #Egeneration #Eof #Ea
#Esecondary #Emessenger #Eknown #Eas
a. IP3
b. cGTP
c. DAG
d. cAMP
e. Calcium #Eions
8. What #Eis #Ethe #Emechanism #Eof #Eaction #Eof #ESildenafil, #Ea #Edrug #Epopularly #Eknown #Eas #Eviagra?
a. Inhibits #Ephosphodiesterase #E(PDE) #Eleading #Eto #Eincrease #EcAMP
b. Inhibits #EPDE #Eleading #Eto #Eincrease #EcGMP
c. Stimulates #Eadenylyl #Ecyclase #Eleading #Eto #Eincrease #EcAMP
d. Stimulates #Eguanylyl #Ecyclase #Eleading #Eto #Eincrease #EcGMP
e. Inhibits #Ephosphodiesterase #Eleading #Eto #Eincrease #EcGMP
9. Drugs #Ethat #Eactivate #Ethe #Ephospholipase #EC-inositol #Ephosphate #Esystem #Esuch #Eas #Ealpha-adrenergic
#Eagonists #Elike #Ephenylephrine #Eprimarily #Ecause #Ean #Eincrease #Ein #Ethe #Eintracellular #Elevels #Eof #Ewhich
#Eion?
a. Calcium
, b. Magnesium
c. Sodium
d. Potassium
e. Chloride
10. Which #Eof #Ethe #Efollowing #Estetements #Echaracterizes #Ecompetitive #Eantagonism?
a. There #Eis #Ea #Eshift #Eof #Ethe # E agonist #Elog #Econcentration-effect #Ecurve #Eto #Ethe #Eright #Eand
#Edownwards
b. There #Eis #Ea #Eshift #Eof #Ethe #Eagonist #Elog #Econcentration-effect #Ecurve #Eto #Ethe #Eright #Ewithout #Ea
#Echange #Eon #Ethe #Eslope #Eor #Eamplitude
c. There #Eis #Ean #Eexponential #Erelationship #Ebetween #Edose #Eratio #Eand #Eantagonist #Econcentration
d. There #Eis #Eno #Ecompetition #Efor #Ethe #Ebinding #Esites
e. There #Eis #Ea #Eshift #Eof #Ethe #Eagonist #Elog-concentration #Eeffect #Ecurve #Eto #Ethe #Eleft #Ewithout #Ea
#Echange #Ein #Eslope #Eand #Eamplitude
11. The #Eminimum #Edose #Ethat #Eproduces #Ethe #Emaximum #Eachievable #Eresponse #Eis #Eknown #Eas
a. Potency
b. ED50
c. LD50
d. Ceiling #Edose
e. Minimum #Eeffective #Edose
12. The #Emedium #Edose, #Eor #Ethe #Edose #Eof #Ethe #Edrug #Ethat #Eproduces #Ehalf #Eof #Ethe #Emaximum #Eachievable
#Eresponse #Eis #Ecalled
a. Potency d. #ECeiling #Edose
b. LD50 e. #EBinding #Econstant
c. Therapeutic #Eindex
13. What #Eis #Edescribed #Eby #Ethe #Eequation #Egiven #Eas
#Efollows: #EResponse=f #E(EN #Etotal # E . # E Xa
# E / #E(Xa # E + #EKa)
a. Relationship #Ebetween #Eoccupancy #Eof #Ereceptor #Eand #Ethe #Edose #Eof #Ethe #Edrug
b. Relationship #Ebetween #Eoccupancy #Eof #Ereceptor #Eand #Eresponse #Eto #Ethe #Edrug
c. Relationship #Ebetween #Ethe #Edose #Eof #Ethe #Edrug #Eand #Ethe #Eresponse #Eto #Ethe #Edrug
d. Relationship #Ebetween #Ethe #Enumber #Eof #Ereceptors #Eand #Ethe #Edose #Eof #Ethe #Edrug
e. Relationship #Ebetween #Ethe #Eresponse #Eto #Ethe #Edrug #Eand #Ethe #Etransducer #Efunction #Eof #Ethe
#Etissues
14. Competitive #Eantagonist #Eof #Ethe #Ereceptors #Eof #EDopamine #Eand #EBenzodiazepine #Eare #Eexpected #Eto
#Eproduced #Ewhich #Eeffect?
a. Reversal #Eof #Ethe #Eintrinsic #Eactivity #Eof #Ethe #Ereceptors
b. Maintain #Ethe #Econsitutive #Eactivity #Eof #Ethe #Ereceptors
c. Stimulate #Ethe #Econstitutive #Eactivity #Eof #Ethe #Ereceptors
d. Stimulate #Ethe #Econstitutive #Eactivity #Eof #Ethe #Erecptorsin #Ethe #Eabsence #Eof #Eany #Eligand
e. Produce #Ea #Enegative #Eefficacy
15. The #EPT-INR #Eof #Ea #Epatient #Ewith #EWarfarin #Ehas #Ebeen #Emaintained #Eat #E2.5 #Efor #Ethe #Elast #E3 #Emonths. #E1
#Eweek #Eearlier, #Ethe #Epatient #Ewas #Egiven #EPhenobarbital. #EWhat #Ecan #Ebe #Eexpected #Ewith #Ethe #EPT-INR
#Eof #Ethe #Epatient?
a. Increased #EPT-INR
b. Decreased #EPT-INR
c. Maintained #EPT-INR
16. Phenobarbital #Ewhen #Egiven #Eto #Ea #Epatient #Eon #Echronic #Ewarfarin #Eis #Eclassified #Eas
a. Pharmacodynamic #E antagonist
b. Pharmacokinetic # E antagonist
c. Physiologic #Eantagonist
d. Synergistic #Eagonist
e. Additive #Eagonist
17. Digibind #Ewhich #Eeffetively #Eterminates #Ethe #Eaction #Eof #EDigitalis #Eglycosides #Eis #Eclassified #Eas
