NCLEX-RN Safety and Infection Control
(42 LATEST QUESTIONS 2025
QUESTION 1
The nurse is preparing a client for surgery. Which methods are appropriate for the nurse to use in
removing excessive body hair?
Select all that apply.
1. Shaving the hair with a razor.
2. Removing the hair with clippers.
3. Lathering the skin with soap and water prior to shaving with a razor.
4. Using a depilatory cream.
5. Always use a new, sharp razor.
(2. & 4. Correct: Not removing the hair at all is preferred, but if this is not an option the use of clippers or
a depilatory cream may be used to prevent trauma to the skin before surgery.
QUESTION 2
The nurse is planning to teach a group of assisted living residents about tuberculosis (TB) infection.
What should the nurse include?
Select all that apply.
1. Cover mouth when coughing.
2. Proper handwashing.
3. Obtain a TB skin test.
4. Obtain a yearly chest x-ray.
5. Proper disposal of tissues.
(1., 2., 3. & 5. Correct: In an effort to prevent transmission of TB to others, the nurse should carefully
instruct about the importance of hygiene measures, including mouth care, covering the mouth when
coughing and sneezing, proper disposal of tissues, and hand hygiene. A TB skin test is especially
important when living in tight quarters such as an assisted living center.
,QUESTION 3
Which client diagnosis would require the nurse to initiate droplet precaution?
1. Methicillin-resistant Staphylococcus aureus (MRSA)
2. Varicella
3. Vancomycin-resistant enterococci (VRE)
4. Whooping cough
(4. Correct: Droplet isolation precautions are used for diseases or germs that are spread in tiny droplets
caused by coughing and sneezing (examples: pneumonia, influenza, whooping cough, bacterial
meningitis). Healthcare workers should wear a surgical mask while in the room. Mask must be discarded
in trash after leaving the room. Clean hands (hand washing or use hand sanitizer) when they enter the
room and when they leave the room.
QUESTION 4
A new mother calls the clinic and tells the nurse, "I don't have any help taking care of my 3 week old
baby. I don't know what to do. I just feel like I can't take care of him anymore. I wish I never had him
sometimes. Maybe then my husband would spend more time at home." What would be the nurse's best
response?
1. "You are experiencing maternity blues, which will go away on its own."
2. "You are just tired. Tell your husband that you need his help."
3. "Come to the clinic now so that we can help you."
4. "Have you thought about getting a family member to help with the baby?"
(3. Correct: This client is exhibiting signs of postpartum psychosis. Post partum psychosis is characterized
by depressed mood, agitation, indecision, lack of concentration, guilt, and an abnormal attitude toward
bodily functions. There is a lack of interest in or rejection of the baby, or a morbid fear that the baby
may be harmed. Risks of suicide and infanticide should not be overlooked.
QUESTION 5
The nurse is caring for a client with a perineal burn. The skin is not intact. What signs are suggestive of
infection? Select all that apply.
1. Color Changes
2. Drainage
3. Odor
, 4. Fever
5. Bleeding
6. Increased Pain
(1., 2., 3., 4. & 6. Correct: Infections may cause color changes, drainage, odor, fever, & increased pain.
Bleeding is a sign of hemorrhage, trauma, anemia or other blood disorders but not infection.
QUESTION 6
The new nurse is caring for a client receiving oxygen by nasal cannula. Which action would require the
charge nurse to intervene?
1. Apply gauze padding beneath the tubing.
2. Use petroleum jelly on the nares and cheeks.
3. Provide mouth and nose care every 4 hours as needed.
4. Place the oxygen tubing above the ears.
2. Use petroleum jelly on the nares and cheeks.
(2. Correct: Petroleum jelly is a combustible substance. It should not be used with oxygen therapy.
QUESTION 7
The nurse administers chemotherapeutic drugs to a client with breast cancer. Where should the nurse
dispose of the medication vials?
1. In a puncture-resistant biohazard container
2. In a chemotherapy sharps container
3. In a biohazard waste container
4. In a chemical container
2. In a chemotherapy sharps container
(2. Correct: Empty vials and sharps such as needles and syringes used in delivering chemotherapy agents
should be disposed of in a chemotherapy sharps container. These waste containers are designed to
protect workers from injuries and are disposed of by incineration at regulated medical waste facilities.
QUESTION 8
These clients have arrived at the emergency department (ED) following an explosion at a local industrial
plant. The ED is operating under disaster protocol. Which client should be treated first?
(42 LATEST QUESTIONS 2025
QUESTION 1
The nurse is preparing a client for surgery. Which methods are appropriate for the nurse to use in
removing excessive body hair?
Select all that apply.
1. Shaving the hair with a razor.
2. Removing the hair with clippers.
3. Lathering the skin with soap and water prior to shaving with a razor.
4. Using a depilatory cream.
5. Always use a new, sharp razor.
(2. & 4. Correct: Not removing the hair at all is preferred, but if this is not an option the use of clippers or
a depilatory cream may be used to prevent trauma to the skin before surgery.
QUESTION 2
The nurse is planning to teach a group of assisted living residents about tuberculosis (TB) infection.
What should the nurse include?
Select all that apply.
1. Cover mouth when coughing.
2. Proper handwashing.
3. Obtain a TB skin test.
4. Obtain a yearly chest x-ray.
5. Proper disposal of tissues.
(1., 2., 3. & 5. Correct: In an effort to prevent transmission of TB to others, the nurse should carefully
instruct about the importance of hygiene measures, including mouth care, covering the mouth when
coughing and sneezing, proper disposal of tissues, and hand hygiene. A TB skin test is especially
important when living in tight quarters such as an assisted living center.
,QUESTION 3
Which client diagnosis would require the nurse to initiate droplet precaution?
1. Methicillin-resistant Staphylococcus aureus (MRSA)
2. Varicella
3. Vancomycin-resistant enterococci (VRE)
4. Whooping cough
(4. Correct: Droplet isolation precautions are used for diseases or germs that are spread in tiny droplets
caused by coughing and sneezing (examples: pneumonia, influenza, whooping cough, bacterial
meningitis). Healthcare workers should wear a surgical mask while in the room. Mask must be discarded
in trash after leaving the room. Clean hands (hand washing or use hand sanitizer) when they enter the
room and when they leave the room.
QUESTION 4
A new mother calls the clinic and tells the nurse, "I don't have any help taking care of my 3 week old
baby. I don't know what to do. I just feel like I can't take care of him anymore. I wish I never had him
sometimes. Maybe then my husband would spend more time at home." What would be the nurse's best
response?
1. "You are experiencing maternity blues, which will go away on its own."
2. "You are just tired. Tell your husband that you need his help."
3. "Come to the clinic now so that we can help you."
4. "Have you thought about getting a family member to help with the baby?"
(3. Correct: This client is exhibiting signs of postpartum psychosis. Post partum psychosis is characterized
by depressed mood, agitation, indecision, lack of concentration, guilt, and an abnormal attitude toward
bodily functions. There is a lack of interest in or rejection of the baby, or a morbid fear that the baby
may be harmed. Risks of suicide and infanticide should not be overlooked.
QUESTION 5
The nurse is caring for a client with a perineal burn. The skin is not intact. What signs are suggestive of
infection? Select all that apply.
1. Color Changes
2. Drainage
3. Odor
, 4. Fever
5. Bleeding
6. Increased Pain
(1., 2., 3., 4. & 6. Correct: Infections may cause color changes, drainage, odor, fever, & increased pain.
Bleeding is a sign of hemorrhage, trauma, anemia or other blood disorders but not infection.
QUESTION 6
The new nurse is caring for a client receiving oxygen by nasal cannula. Which action would require the
charge nurse to intervene?
1. Apply gauze padding beneath the tubing.
2. Use petroleum jelly on the nares and cheeks.
3. Provide mouth and nose care every 4 hours as needed.
4. Place the oxygen tubing above the ears.
2. Use petroleum jelly on the nares and cheeks.
(2. Correct: Petroleum jelly is a combustible substance. It should not be used with oxygen therapy.
QUESTION 7
The nurse administers chemotherapeutic drugs to a client with breast cancer. Where should the nurse
dispose of the medication vials?
1. In a puncture-resistant biohazard container
2. In a chemotherapy sharps container
3. In a biohazard waste container
4. In a chemical container
2. In a chemotherapy sharps container
(2. Correct: Empty vials and sharps such as needles and syringes used in delivering chemotherapy agents
should be disposed of in a chemotherapy sharps container. These waste containers are designed to
protect workers from injuries and are disposed of by incineration at regulated medical waste facilities.
QUESTION 8
These clients have arrived at the emergency department (ED) following an explosion at a local industrial
plant. The ED is operating under disaster protocol. Which client should be treated first?
