PMT
Oxford Cambridge and RSA
Monday 12 October 2020 – Morning
A Level Biology B (Advancing Biology)
H422/01 Fundamentals of biology
Time allowed: 2 hours 15 minutes
You can use:
•a scientific or graphical calculator
•a ruler (cm/mm)
*H42201*
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be given
for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 110.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 32 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2020 [601/4720/9]
DC (CE/SW) 1 93338/5
OCR is an exempt Charity
Turn over
, PM
2
SECTION A
You should spend a maximum of 40 minutes on this section.
Write your answer to each question in the box provided.
Answer all the questions.
1 Which of the options, A to D, is the potency of adult bone marrow stem cells?
A multipotent
B pluripotent
C totipotent
D unipotent
Your answer
[1]
2 Which of the molecules, A to D, reduces the permeability of the plasma membrane to most
substances?
A carbohydrate
B cholesterol
C glycoprotein D protein
Your answer
[1]
3 To which of the substances, A to D, is the plasma membrane of an axon least permeable?
A ATP
B glucose
C K+ D Na+
Your answer
[1]
© OCR 2020
, PM
3
4 Which of the following, A to D, describes the structure of haemoglobin?
A each of the four polypeptide chains is combined with an identical haem group
B each polypeptide chain has a quaternary structure
C the quaternary structure of each polypeptide chain contains ionic bonds
D two polypeptide chains contain an alpha haem group and two contain a beta haem group
Your answer
[1]
5 Which of the following statements is/are true of anaerobic respiration in both animal and yeast
cells?
1: Pyruvate is produced in glycolysis.
2: Reduced NAD is oxidised.
3: Two molecules of ATP are produced net, per glucose molecule.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct D Only 1 is correct
Your answer
[1]
6 The diagram below shows the structure of an amino acid. Four regions are labelled A to D.
B
H H O
H N C C OH
R
D A C
Which of the regions, A to D, is removed from the amino acid to produce urea?
Your answer
© OCR 2020 Turn over
, PM
4
[1]
7 Which of the cell organelles, A to D, is most likely to increase the mass of a newly-translated
protein?
A Golgi apparatus
B lysosome
C nucleus
D smooth endoplasmic reticulum
Your answer
[1]
8 Which of the following statements is/are true of variable number tandem repeats (VNTRs) and
single nucleotide polymorphisms (SNPs)?
1: Both VNTRs and SNPs are only found in intronic regions of DNA.
2: VNTRs are used in forensics to identify potential crime suspects.
3: VNTRs are generally more polymorphic than SNPs.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct D Only 1 is correct
Your answer
[1]
9 Which of the protein types, A to D, could be coded for by a tumour suppressor gene? A
a protein activated by a growth factor
B a protein that helps prevent apoptosis
C a protein that promotes the cell cycle D a protein that
repairs DNA
© OCR 2020
Oxford Cambridge and RSA
Monday 12 October 2020 – Morning
A Level Biology B (Advancing Biology)
H422/01 Fundamentals of biology
Time allowed: 2 hours 15 minutes
You can use:
•a scientific or graphical calculator
•a ruler (cm/mm)
*H42201*
Please write clearly in black ink. Do not write in the barcodes.
Centre number Candidate number
First name(s)
Last name
INSTRUCTIONS
• Use black ink. You can use an HB pencil, but only for graphs and diagrams.
• Write your answer to each question in the space provided. If you need extra space use
the lined pages at the end of this booklet. The question numbers must be clearly shown.
• Answer all the questions.
• Where appropriate, your answer should be supported with working. Marks might be given
for using a correct method, even if your answer is wrong.
INFORMATION
• The total mark for this paper is 110.
• The marks for each question are shown in brackets [ ].
• Quality of extended response will be assessed in questions marked with an asterisk (*).
• This document has 32 pages.
ADVICE
• Read each question carefully before you start your answer.
© OCR 2020 [601/4720/9]
DC (CE/SW) 1 93338/5
OCR is an exempt Charity
Turn over
, PM
2
SECTION A
You should spend a maximum of 40 minutes on this section.
Write your answer to each question in the box provided.
Answer all the questions.
1 Which of the options, A to D, is the potency of adult bone marrow stem cells?
A multipotent
B pluripotent
C totipotent
D unipotent
Your answer
[1]
2 Which of the molecules, A to D, reduces the permeability of the plasma membrane to most
substances?
A carbohydrate
B cholesterol
C glycoprotein D protein
Your answer
[1]
3 To which of the substances, A to D, is the plasma membrane of an axon least permeable?
A ATP
B glucose
C K+ D Na+
Your answer
[1]
© OCR 2020
, PM
3
4 Which of the following, A to D, describes the structure of haemoglobin?
A each of the four polypeptide chains is combined with an identical haem group
B each polypeptide chain has a quaternary structure
C the quaternary structure of each polypeptide chain contains ionic bonds
D two polypeptide chains contain an alpha haem group and two contain a beta haem group
Your answer
[1]
5 Which of the following statements is/are true of anaerobic respiration in both animal and yeast
cells?
1: Pyruvate is produced in glycolysis.
2: Reduced NAD is oxidised.
3: Two molecules of ATP are produced net, per glucose molecule.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct D Only 1 is correct
Your answer
[1]
6 The diagram below shows the structure of an amino acid. Four regions are labelled A to D.
B
H H O
H N C C OH
R
D A C
Which of the regions, A to D, is removed from the amino acid to produce urea?
Your answer
© OCR 2020 Turn over
, PM
4
[1]
7 Which of the cell organelles, A to D, is most likely to increase the mass of a newly-translated
protein?
A Golgi apparatus
B lysosome
C nucleus
D smooth endoplasmic reticulum
Your answer
[1]
8 Which of the following statements is/are true of variable number tandem repeats (VNTRs) and
single nucleotide polymorphisms (SNPs)?
1: Both VNTRs and SNPs are only found in intronic regions of DNA.
2: VNTRs are used in forensics to identify potential crime suspects.
3: VNTRs are generally more polymorphic than SNPs.
A 1, 2 and 3 are correct
B Only 1 and 2 are correct
C Only 2 and 3 are correct D Only 1 is correct
Your answer
[1]
9 Which of the protein types, A to D, could be coded for by a tumour suppressor gene? A
a protein activated by a growth factor
B a protein that helps prevent apoptosis
C a protein that promotes the cell cycle D a protein that
repairs DNA
© OCR 2020
