NR565 / NR565 Advanced Pharmacology
Fundamentals Midterm / Final Exam|
Questions and 100 % Correct Answers |
Rated A Quiz bank | LATEST, 2025/
2026 | Chamberlain College
1. Kasey fractured his ankle in two places and is asking for medication for his pain.
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The appropriate first-line medication would be:
bq bq bq bq bq bq
- Acetaminophen with hydrocodone (Vicodin) bq bq bq
2. Jack, age 8, has attention deficit disorder (ADD) and is prescribed
bq bq bq bq bq bq bq bq bq bq
methylphenidate (Ritalin). He and his parents should be educated about the side
bq bq bq bq bq bq bq bq bq bq bq bq
effects of methylphenidate, which are:
bq bq bq bq bq
- Insomnia and decreased appetite bq bq bq
3. Monitoring for a child on methylphenidate for attention deficit hyperactivity
bq bq bq bq bq bq bq bq bq
disorder (ADHD) includes:
bq bq bq
- ADHD symptoms bq
- Routine height and weight checks bq bq bq bq
- Amount of methylphenidate being used bq bq bq bq
4. When prescribing Adderall (amphetamine and dextroamphetamine) to adults with ADHD
bq bq bq bq bq bq bq bq bq
the nurse practitioner will need to monitor:
bq bq bq bq bq bq bq
- Blood pressure bq
5. Common mistakes practitioners make in treating anxiety disorders include:
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- Thinking a partial response to medication is acceptable
bq bq bq bq bq bq bq
6. An appropriate first-line drug to try for mild to moderate generalized anxiety
bq bq bq bq bq bq bq bq bq bq bq
disorder would be:
bq bq bq
- Buspirone (Buspar) bq
7. An appropriate drug to initially treat panic disorder is:
bq bq bq bq bq bq bq bq
- Diazepam (Valium) bq
8. Prior to starting antidepressants, patients should have laboratory testing to rule out:
bq bq bq bq bq bq bq bq bq bq bq
- Hypothyroidism
,9. David is a 34-year-old patient who is starting on paroxetine (Paxil) for
bq bq bq bq bq bq bq bq bq bq bq
depression. David's education regarding his medication would include:
bq bq bq bq bq bq bq bq
- He may experience sexual dysfunction beginning a month after he starts therapy.
bq bq bq bq bq bq bq bq bq bq bq
10. Jamison has been prescribed citalopram (Celexa) to treat his depression. Education
bq bq bq bq bq bq bq bq bq bq
bqregarding how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants
bq bq bq bq bq bq bq bq
bqwork would be:bq bq
- Appetite and concentration improve in the first 1 to 2 weeks.
bq bq bq bq bq bq bq bq bq bq
11. The racial difference in drug pharmacokinetics seen in American Indian or
bq bq bq bq bq bq bq bq bq bq
bqAlaskan Natives are: bq bq
- Largely unknown due to lack of studies of this population
bq bq bq bq bq bq bq bq bq
12. Pharmacokinetics among Asians are universal to all the Asian ethnic groups. bq bq bq bq bq bq bq bq bq bq
A. True
B. False
13. Alterations in drug metabolism among Asians may lead to:
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- Slower metabolism of antidepressants, requiring lower doses
bq bq bq bq bq bq
14. Asians from Eastern Asia are known to be fast acetylators. Fast acetylators:
bq bq bq bq bq bq bq bq bq bq bq
- Require higher doses of drugs metabolized by acetylization to achieve efficacy
bq bq bq bq bq bq bq bq bq bq
15. Hispanic native healers (curanderas):
bq bq bq
A. Are not heavily utilized by Hispanics who immigrate to the United States
bq bq bq bq bq bq bq bq bq bq bq
B. Use herbs and teas in their treatment of illness
bq bq bq bq bq bq bq bq
C. Provide unsafe advice to Hispanics and should not be trusted
bq bq bq bq bq bq bq bq bq
D. Need to be licensed in their home country in order to practice in the United States
bq bq bq bq bq bq bq bq bq bq bq bq bq bq bq b q
16. Genetic polymorphisms account for differences in metabolism, including:
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- Poor metabolizers, who lack a working enzyme
bq bq bq bq bq bq
- Intermediate metabolizers, who have one working, wild-type allele and one bq bq bq bq bq bq bq bq bq
mutant allele
bq bq
- Extensive metabolizers, with two normally functioning alleles
bq bq bq bq bq bq
17. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
bq bq bq bq bq bq bq bq bq bq
- Increased dosages needed of drugs metabolized by 2D6, such as the
bq bq bq bq bq bq bq bq bq bq
selective serotonin reuptake inhibitors
bq bq bq bq
18. Drugs that use CYP 3A4 isoenzymes for metabolism may:
bq bq bq bq bq bq bq bq
- Induce the metabolism of another drug bq bq bq bq bq
, - Inhibit the metabolism of another drug
bq bq bq bq bq
19. Rifampin is a nonspecific CYP450 inducer that may:
bq bq bq bq bq bq bq
- Induce the metabolism of drugs, such as oral contraceptives, leading to
bq bq bq bq bq bq bq bq bq bq
therapeutic failure
bq bq
20. Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
bq bq bq bq bq bq bq bq bq bq bq
- Increased levels of a co-administered drug, such as digoxin, that requires
bq bq bq bq bq bq bq bq bq bq
P- glycoprotein for absorption and elimination
bq bq bq bq bq bq
21. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to:
bq bq bq bq bq bq bq bq bq bq bq
- Decreased response to warfarin bq bq bq
22. Genetic testing for VCORC1 mutation to assess potential warfarin resistance is
bq bq bq bq bq bq bq bq bq bq
required prior to prescribing warfarin.
bq bq bq bq bq
A. True
B. False
23. Pharmacogenetic testing is required by the U.S. Food and Drug Administration prior bq bq bq bq bq bq bq bq bq bq bq
bqto prescribing:
bq
- Cetuximab
24. Carbamazepine has a Black Box Warning recommending testing for the HLA- bq bq bq bq bq bq bq bq bq bq
B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
bq bq bq bq bq bq bq bq bq bq bq bq
- Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-
bq bq bq bq bq bq bq bq bq
B*1502 allele bq
25. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38
bq bq bq bq bq bq bq bq bq bq bq bq
bqis inactivated by the body may lead to
bq bq bq bq bq bq bq
- Increased adverse drug reactions, such as neutropenia bq bq bq bq bq bq
26. Patients who have a poor metabolism phenotype will have:
bq bq bq bq bq bq bq bq
- Slowed metabolism of a prodrug into an active drug, leading to accumulation
bq bq bq bq bq bq bq bq bq bq bq
of prodrugbq bq
27. A patient's nutritional intake and laboratory results reflect hypoalbuminemia. This
bq bq bq bq bq bq bq bq bq
bqis critical to prescribing because:
bq bq bq bq
- Distribution of drugs to target tissue may be affected. bq bq bq bq bq bq bq bq
28. Drugs that have a significant first-pass effect:
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- Are rapidly metabolized by the liver and may have little if any desired action
bq bq bq bq bq bq bq bq bq bq bq bq bq
29. The route of excretion of a volatile drug will likely be the:
bq bq bq bq bq bq bq bq bq bq bq
- Lungs
Fundamentals Midterm / Final Exam|
Questions and 100 % Correct Answers |
Rated A Quiz bank | LATEST, 2025/
2026 | Chamberlain College
1. Kasey fractured his ankle in two places and is asking for medication for his pain.
bq bq bq bq bq bq bq bq bq bq bq bq bq bq
The appropriate first-line medication would be:
bq bq bq bq bq bq
- Acetaminophen with hydrocodone (Vicodin) bq bq bq
2. Jack, age 8, has attention deficit disorder (ADD) and is prescribed
bq bq bq bq bq bq bq bq bq bq
methylphenidate (Ritalin). He and his parents should be educated about the side
bq bq bq bq bq bq bq bq bq bq bq bq
effects of methylphenidate, which are:
bq bq bq bq bq
- Insomnia and decreased appetite bq bq bq
3. Monitoring for a child on methylphenidate for attention deficit hyperactivity
bq bq bq bq bq bq bq bq bq
disorder (ADHD) includes:
bq bq bq
- ADHD symptoms bq
- Routine height and weight checks bq bq bq bq
- Amount of methylphenidate being used bq bq bq bq
4. When prescribing Adderall (amphetamine and dextroamphetamine) to adults with ADHD
bq bq bq bq bq bq bq bq bq
the nurse practitioner will need to monitor:
bq bq bq bq bq bq bq
- Blood pressure bq
5. Common mistakes practitioners make in treating anxiety disorders include:
bq bq bq bq bq bq bq bq
- Thinking a partial response to medication is acceptable
bq bq bq bq bq bq bq
6. An appropriate first-line drug to try for mild to moderate generalized anxiety
bq bq bq bq bq bq bq bq bq bq bq
disorder would be:
bq bq bq
- Buspirone (Buspar) bq
7. An appropriate drug to initially treat panic disorder is:
bq bq bq bq bq bq bq bq
- Diazepam (Valium) bq
8. Prior to starting antidepressants, patients should have laboratory testing to rule out:
bq bq bq bq bq bq bq bq bq bq bq
- Hypothyroidism
,9. David is a 34-year-old patient who is starting on paroxetine (Paxil) for
bq bq bq bq bq bq bq bq bq bq bq
depression. David's education regarding his medication would include:
bq bq bq bq bq bq bq bq
- He may experience sexual dysfunction beginning a month after he starts therapy.
bq bq bq bq bq bq bq bq bq bq bq
10. Jamison has been prescribed citalopram (Celexa) to treat his depression. Education
bq bq bq bq bq bq bq bq bq bq
bqregarding how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants
bq bq bq bq bq bq bq bq
bqwork would be:bq bq
- Appetite and concentration improve in the first 1 to 2 weeks.
bq bq bq bq bq bq bq bq bq bq
11. The racial difference in drug pharmacokinetics seen in American Indian or
bq bq bq bq bq bq bq bq bq bq
bqAlaskan Natives are: bq bq
- Largely unknown due to lack of studies of this population
bq bq bq bq bq bq bq bq bq
12. Pharmacokinetics among Asians are universal to all the Asian ethnic groups. bq bq bq bq bq bq bq bq bq bq
A. True
B. False
13. Alterations in drug metabolism among Asians may lead to:
bq bq bq bq bq bq bq bq
- Slower metabolism of antidepressants, requiring lower doses
bq bq bq bq bq bq
14. Asians from Eastern Asia are known to be fast acetylators. Fast acetylators:
bq bq bq bq bq bq bq bq bq bq bq
- Require higher doses of drugs metabolized by acetylization to achieve efficacy
bq bq bq bq bq bq bq bq bq bq
15. Hispanic native healers (curanderas):
bq bq bq
A. Are not heavily utilized by Hispanics who immigrate to the United States
bq bq bq bq bq bq bq bq bq bq bq
B. Use herbs and teas in their treatment of illness
bq bq bq bq bq bq bq bq
C. Provide unsafe advice to Hispanics and should not be trusted
bq bq bq bq bq bq bq bq bq
D. Need to be licensed in their home country in order to practice in the United States
bq bq bq bq bq bq bq bq bq bq bq bq bq bq bq b q
16. Genetic polymorphisms account for differences in metabolism, including:
bq bq bq bq bq bq bq
- Poor metabolizers, who lack a working enzyme
bq bq bq bq bq bq
- Intermediate metabolizers, who have one working, wild-type allele and one bq bq bq bq bq bq bq bq bq
mutant allele
bq bq
- Extensive metabolizers, with two normally functioning alleles
bq bq bq bq bq bq
17. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
bq bq bq bq bq bq bq bq bq bq
- Increased dosages needed of drugs metabolized by 2D6, such as the
bq bq bq bq bq bq bq bq bq bq
selective serotonin reuptake inhibitors
bq bq bq bq
18. Drugs that use CYP 3A4 isoenzymes for metabolism may:
bq bq bq bq bq bq bq bq
- Induce the metabolism of another drug bq bq bq bq bq
, - Inhibit the metabolism of another drug
bq bq bq bq bq
19. Rifampin is a nonspecific CYP450 inducer that may:
bq bq bq bq bq bq bq
- Induce the metabolism of drugs, such as oral contraceptives, leading to
bq bq bq bq bq bq bq bq bq bq
therapeutic failure
bq bq
20. Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
bq bq bq bq bq bq bq bq bq bq bq
- Increased levels of a co-administered drug, such as digoxin, that requires
bq bq bq bq bq bq bq bq bq bq
P- glycoprotein for absorption and elimination
bq bq bq bq bq bq
21. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to:
bq bq bq bq bq bq bq bq bq bq bq
- Decreased response to warfarin bq bq bq
22. Genetic testing for VCORC1 mutation to assess potential warfarin resistance is
bq bq bq bq bq bq bq bq bq bq
required prior to prescribing warfarin.
bq bq bq bq bq
A. True
B. False
23. Pharmacogenetic testing is required by the U.S. Food and Drug Administration prior bq bq bq bq bq bq bq bq bq bq bq
bqto prescribing:
bq
- Cetuximab
24. Carbamazepine has a Black Box Warning recommending testing for the HLA- bq bq bq bq bq bq bq bq bq bq
B*1502 allele in patients with Asian ancestry prior to starting therapy due to:
bq bq bq bq bq bq bq bq bq bq bq bq
- Increased risk for Stevens-Johnson syndrome in Asian patients with HLA-
bq bq bq bq bq bq bq bq bq
B*1502 allele bq
25. A genetic variation in how the metabolite of the cancer drug irinotecan SN-38
bq bq bq bq bq bq bq bq bq bq bq bq
bqis inactivated by the body may lead to
bq bq bq bq bq bq bq
- Increased adverse drug reactions, such as neutropenia bq bq bq bq bq bq
26. Patients who have a poor metabolism phenotype will have:
bq bq bq bq bq bq bq bq
- Slowed metabolism of a prodrug into an active drug, leading to accumulation
bq bq bq bq bq bq bq bq bq bq bq
of prodrugbq bq
27. A patient's nutritional intake and laboratory results reflect hypoalbuminemia. This
bq bq bq bq bq bq bq bq bq
bqis critical to prescribing because:
bq bq bq bq
- Distribution of drugs to target tissue may be affected. bq bq bq bq bq bq bq bq
28. Drugs that have a significant first-pass effect:
bq bq bq bq bq bq
- Are rapidly metabolized by the liver and may have little if any desired action
bq bq bq bq bq bq bq bq bq bq bq bq bq
29. The route of excretion of a volatile drug will likely be the:
bq bq bq bq bq bq bq bq bq bq bq
- Lungs
