, Test Bank mi
to accompany
mi
Psychopharmacology, Fourth Edition mi mi
Meyer • Quenzer mi mi
Chapter 1: Principles of Pharmacology mi mi mi mi
Multiple Choice mi
1. refer(s) to specific molecular changes that occur when a drug binds to a
mi mi mi mi mi mi mi mi mi mi mi mi mi
particular target site or receptor, while
mi mi mi mi mi
are the resulting widespread alterations in function.
mi mi mi mi mi mi
a. Drug action; therapeutic effects
mi mi mi
b. Side effects; drug effects
mi mi mi
c. Therapeutic effects; side effects mi mi mi
d. Drug action; drug effects
mi mi mi
Answer: d mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
2. After drug administration has occurred, the amount of drug in the blood that is free
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
to bind at specific target sites is referred to as
mi mi mi mi mi mi mi mi mi mi
a. the therapeutic dose.
mi mi
b. first-pass effects. mi
c. bioavailability.
d. ED50.
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
3. The specific molecular changes that occur when a drug binds to a particular target s
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
ite or receptor are referred to as
mi mi mi mi mi mi
a. drug effects.mi
b. drug action. mi
c. side effects.
mi
d. placebo effects. mi
Answer: b mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
4. Which of the following is not a possible explanation for placebo effects?
mi mi mi mi mi mi mi mi mi mi mi
a. Pavlovian conditioning mi
b. Genetic variation mi
c. Drug competition mi
d. Expectation of outcome mi mi
Answer: c mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
Page 1 of 247
mi mi mi
,5. The administration of oxytocin has been proposed as a treatment for autism. mi mi mi mi mi mi mi mi mi mi
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
6. Which factor does not affect the pharmacokinetics of a drug?
mi mi mi mi mi mi mi mi mi
a. Route of administration
mi mi
b. Lipid solubility
mi
c. Depot binding mi
d. Drug action mi
Answer: d mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
7. First-pass metabolism occurs when drugs are taken
mi mi mi mi mi mi
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
8. The area postrema is one area in the brain where the
mi mi is not complete.
mi mi mi mi mi mi mi mi mi mi
a. cerebrospinal fluid mi
b. blood–brain barrier mi
c. choroid plexus mi
d. phospholipid membrane mi
Answer: b mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
9. First-pass metabolism occurs with orally administered drugs because
mi mi mi mi mi mi mi
a. their absorption is slowed by food.
mi mi mi mi mi
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wa
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
y to general circulation.
mi mi mi
c. drugs must first survive the acidic environment of the stomach.
mi mi mi mi mi mi mi mi mi
d. salivary enzymes in the mouth begin the process of metabolism.
mi mi mi mi mi mi mi mi mi
Answer: b mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
10. Toxic substances in the blood trigger a vomiting response by activating the
mi mi mi mi mi mi mi mi mi mi mi
a. blood–brain barrier. mi
b. choroid plexus. mi
c. area postrema.
mi
d. median eminence. mi
Page 2 of 247
mi mi mi
, Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
11. Drugs administered _ mi have the most rapid onset of action. mi mi mi mi mi mi mi
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
12. Ionization of a drug depends on the
mi of the solution and the
mi mi mi mi mi mi mi mi mi
of the drug.
mi mi
a. pH; pKa
mi
b. pKa; pH mi
c. concentration; lipid solubility mi mi
d. pH; concentration
mi
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
13. The absorption of a drug depends on all of the following except
mi mi mi mi mi mi mi mi mi mi mi
a. lipid solubility.
mi
b. ionization.
c. body temperature.
mi
d. the concentration of the drug.
mi mi mi mi
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
14. Drugs that are mi should be avoided by women of childbearing age.
mi mi mi mi mi mi mi mi
a. teratogenic
b. able to cross the placental barrier
mi mi mi mi mi
c. psychoactive
d. highly lipid-soluble
mi
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
15. Agents that induce developmental abnormalities in a fetus are known as
mi mi mi mi mi mi mi mi mi mi
a. psychoactive drugs. mi
b. illicit drugs.
mi
c. teratogens.
d. placental drugs. mi
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
16. Depot binding is said to occur when drugs
mi mi mi mi mi mi mi
a. bind to their target sites.
mi mi mi mi
Page 3 of 247
mi mi mi
to accompany
mi
Psychopharmacology, Fourth Edition mi mi
Meyer • Quenzer mi mi
Chapter 1: Principles of Pharmacology mi mi mi mi
Multiple Choice mi
1. refer(s) to specific molecular changes that occur when a drug binds to a
mi mi mi mi mi mi mi mi mi mi mi mi mi
particular target site or receptor, while
mi mi mi mi mi
are the resulting widespread alterations in function.
mi mi mi mi mi mi
a. Drug action; therapeutic effects
mi mi mi
b. Side effects; drug effects
mi mi mi
c. Therapeutic effects; side effects mi mi mi
d. Drug action; drug effects
mi mi mi
Answer: d mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
2. After drug administration has occurred, the amount of drug in the blood that is free
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
to bind at specific target sites is referred to as
mi mi mi mi mi mi mi mi mi mi
a. the therapeutic dose.
mi mi
b. first-pass effects. mi
c. bioavailability.
d. ED50.
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
3. The specific molecular changes that occur when a drug binds to a particular target s
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
ite or receptor are referred to as
mi mi mi mi mi mi
a. drug effects.mi
b. drug action. mi
c. side effects.
mi
d. placebo effects. mi
Answer: b mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
4. Which of the following is not a possible explanation for placebo effects?
mi mi mi mi mi mi mi mi mi mi mi
a. Pavlovian conditioning mi
b. Genetic variation mi
c. Drug competition mi
d. Expectation of outcome mi mi
Answer: c mi
Textbook Reference: Pharmacology: The Science of Drug Action
mi mi mi mi mi mi mi
Page 1 of 247
mi mi mi
,5. The administration of oxytocin has been proposed as a treatment for autism. mi mi mi mi mi mi mi mi mi mi
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
6. Which factor does not affect the pharmacokinetics of a drug?
mi mi mi mi mi mi mi mi mi
a. Route of administration
mi mi
b. Lipid solubility
mi
c. Depot binding mi
d. Drug action mi
Answer: d mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
7. First-pass metabolism occurs when drugs are taken
mi mi mi mi mi mi
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
8. The area postrema is one area in the brain where the
mi mi is not complete.
mi mi mi mi mi mi mi mi mi mi
a. cerebrospinal fluid mi
b. blood–brain barrier mi
c. choroid plexus mi
d. phospholipid membrane mi
Answer: b mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
9. First-pass metabolism occurs with orally administered drugs because
mi mi mi mi mi mi mi
a. their absorption is slowed by food.
mi mi mi mi mi
b. drugs absorbed into the bloodstream from the stomach go to the liver on the wa
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
y to general circulation.
mi mi mi
c. drugs must first survive the acidic environment of the stomach.
mi mi mi mi mi mi mi mi mi
d. salivary enzymes in the mouth begin the process of metabolism.
mi mi mi mi mi mi mi mi mi
Answer: b mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
10. Toxic substances in the blood trigger a vomiting response by activating the
mi mi mi mi mi mi mi mi mi mi mi
a. blood–brain barrier. mi
b. choroid plexus. mi
c. area postrema.
mi
d. median eminence. mi
Page 2 of 247
mi mi mi
, Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
11. Drugs administered _ mi have the most rapid onset of action. mi mi mi mi mi mi mi
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
12. Ionization of a drug depends on the
mi of the solution and the
mi mi mi mi mi mi mi mi mi
of the drug.
mi mi
a. pH; pKa
mi
b. pKa; pH mi
c. concentration; lipid solubility mi mi
d. pH; concentration
mi
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
13. The absorption of a drug depends on all of the following except
mi mi mi mi mi mi mi mi mi mi mi
a. lipid solubility.
mi
b. ionization.
c. body temperature.
mi
d. the concentration of the drug.
mi mi mi mi
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
14. Drugs that are mi should be avoided by women of childbearing age.
mi mi mi mi mi mi mi mi
a. teratogenic
b. able to cross the placental barrier
mi mi mi mi mi
c. psychoactive
d. highly lipid-soluble
mi
Answer: a mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
15. Agents that induce developmental abnormalities in a fetus are known as
mi mi mi mi mi mi mi mi mi mi
a. psychoactive drugs. mi
b. illicit drugs.
mi
c. teratogens.
d. placental drugs. mi
Answer: c mi
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mi mi mi mi mi mi
16. Depot binding is said to occur when drugs
mi mi mi mi mi mi mi
a. bind to their target sites.
mi mi mi mi
Page 3 of 247
mi mi mi
