EndocrinePathology
Diabetes Insipidus intensethirst polyuria w inability to concentrate
urine d t tADH or failure ofresponseto ADH
Central DI Nephrogenic DI
Etiology pit tumor AI trauma surgery hereditaryADHreceptormutation
idiopathic isch encephalopathy 20hypercalcemia tht lithium
Findings I ADH normal or T ADH
WaterDeprivation 501 T in urine minimal change in
test osmolality osmolality
desmopressin Hetz amiloride
Treatment hydration hydration dietary salt
restriction
Hypopituitarism undersecretionof pituitaryhormones dit
nonsecreting pit adenoma craniopharyngioma
Sheehan syndrome ischemicinfarct ofpit following postpartumbleeding
inducedpitgrowth t hypoperfusion
is pregnancy
fx to lactate amenorrhea coldintolerance
Emptysella syndrome atrophy compressionofpituitary idiopathic
common in obesewomen
assoc W intracranial ATN
Pituitary apoplexy suddenhemorrhageofpit often w existing
pituitaryadenoma
severe Hla visual impairment sxs of hypopituitarism
Brain injury
Radiation
Treatment HRT
TTGH acromegaly gigantism
Hyperpituitarism pitadenoma
Findings largetongue w deepfurrows deepvoice large hands feet
facialaging insulinresistance HTN
T risk colorectalpolyps cancer
Diagnosis t serumIGF l pit mass on MRI
Treatment adenoma resection octreotide SS analog
alt receptoragonist dopamineagonist
, Hypothyroidism Hyperthyroidism
Metabolic coldintolerance I sweating T wt heatintolerance T sweating I wt
hyponatremia I BMR dalorigenesis TBMR t calorigenesis
I bloodflow drycoolskin vasodilationTBF warm moist skin
skin hair coarse brittlehair alopecia brittle fine hair oncholysis nails pre
nails nonpittingedemaH2Oretent tibial myxedema in Graves
Ocular periorbitaledema periorbital edema exophthalmos
Graves lidlagretraction
I t motility constipation 9 motility diarrhea Bu
t appetite t appetite
MSK prox Weakness t CK carpal tunnel prox weakness norm Ck
myoedema abnormal osteoporosis I fractures
Ifpi t libido t fertility to libido t fertility abnormal
uterinebleeding uterinebleedinggynecomastia
Neuropsych t activity lethargy fatigue activity restlessness anxiety
I mood I reflexes
weakness insomnia finetremor Treflexes
Cardio t HR DOE I CO THR palpitations dyspnea angina
arrhythmias TBP
TTSH if 107 I TSH
Labs I f Tt Tz Tf Tt TZ
hypercholesterolemia t LDL HDL total cholesterol
Hypothyroidism
Hashimotothyroiditis mostcommoncause in iodine sufficientregions
Al disorder w antithyroidperoxidase antitpolt anti TG antibodies
assoc W HLA DR3 HLA DRS
T risk of Hodgkins lymphoma
may be hyperthyroid in early dx alt thyrotoxicosis w follicularrupture
Hurthlecells lymphoidaggregates w germinalcenters
mod enlarged nontendergoiter
Postpartumthyroiditis self limited arisesupto lyrafterdelivery
transientthyroid abnormalities
Mai Women euthyroidfollowing resolution
thyroidpainless normalsize
lymphocytic infiltrate w occasional germinalcenter
Congenital hypothyroid cretinism alt Abmed maternalhypothyroidism
thyroiddysgenesis I deficiency dyshormonogenetic goiter
Subacutegranulomatousthyroiditis de Queuvain self limiting
oftenpostflu likeillness
VERYtenderthyroid TESR jawpain vainassoc w pain
Diabetes Insipidus intensethirst polyuria w inability to concentrate
urine d t tADH or failure ofresponseto ADH
Central DI Nephrogenic DI
Etiology pit tumor AI trauma surgery hereditaryADHreceptormutation
idiopathic isch encephalopathy 20hypercalcemia tht lithium
Findings I ADH normal or T ADH
WaterDeprivation 501 T in urine minimal change in
test osmolality osmolality
desmopressin Hetz amiloride
Treatment hydration hydration dietary salt
restriction
Hypopituitarism undersecretionof pituitaryhormones dit
nonsecreting pit adenoma craniopharyngioma
Sheehan syndrome ischemicinfarct ofpit following postpartumbleeding
inducedpitgrowth t hypoperfusion
is pregnancy
fx to lactate amenorrhea coldintolerance
Emptysella syndrome atrophy compressionofpituitary idiopathic
common in obesewomen
assoc W intracranial ATN
Pituitary apoplexy suddenhemorrhageofpit often w existing
pituitaryadenoma
severe Hla visual impairment sxs of hypopituitarism
Brain injury
Radiation
Treatment HRT
TTGH acromegaly gigantism
Hyperpituitarism pitadenoma
Findings largetongue w deepfurrows deepvoice large hands feet
facialaging insulinresistance HTN
T risk colorectalpolyps cancer
Diagnosis t serumIGF l pit mass on MRI
Treatment adenoma resection octreotide SS analog
alt receptoragonist dopamineagonist
, Hypothyroidism Hyperthyroidism
Metabolic coldintolerance I sweating T wt heatintolerance T sweating I wt
hyponatremia I BMR dalorigenesis TBMR t calorigenesis
I bloodflow drycoolskin vasodilationTBF warm moist skin
skin hair coarse brittlehair alopecia brittle fine hair oncholysis nails pre
nails nonpittingedemaH2Oretent tibial myxedema in Graves
Ocular periorbitaledema periorbital edema exophthalmos
Graves lidlagretraction
I t motility constipation 9 motility diarrhea Bu
t appetite t appetite
MSK prox Weakness t CK carpal tunnel prox weakness norm Ck
myoedema abnormal osteoporosis I fractures
Ifpi t libido t fertility to libido t fertility abnormal
uterinebleeding uterinebleedinggynecomastia
Neuropsych t activity lethargy fatigue activity restlessness anxiety
I mood I reflexes
weakness insomnia finetremor Treflexes
Cardio t HR DOE I CO THR palpitations dyspnea angina
arrhythmias TBP
TTSH if 107 I TSH
Labs I f Tt Tz Tf Tt TZ
hypercholesterolemia t LDL HDL total cholesterol
Hypothyroidism
Hashimotothyroiditis mostcommoncause in iodine sufficientregions
Al disorder w antithyroidperoxidase antitpolt anti TG antibodies
assoc W HLA DR3 HLA DRS
T risk of Hodgkins lymphoma
may be hyperthyroid in early dx alt thyrotoxicosis w follicularrupture
Hurthlecells lymphoidaggregates w germinalcenters
mod enlarged nontendergoiter
Postpartumthyroiditis self limited arisesupto lyrafterdelivery
transientthyroid abnormalities
Mai Women euthyroidfollowing resolution
thyroidpainless normalsize
lymphocytic infiltrate w occasional germinalcenter
Congenital hypothyroid cretinism alt Abmed maternalhypothyroidism
thyroiddysgenesis I deficiency dyshormonogenetic goiter
Subacutegranulomatousthyroiditis de Queuvain self limiting
oftenpostflu likeillness
VERYtenderthyroid TESR jawpain vainassoc w pain
