PHCH 667 EXAM 2 QUIZ QUESTIONS
AND CORRECT ANSWERS
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost completely
filtered by the glomerulus, approximately 50% of the filtered urea is re-absorbed in the kidney
tubules.
A) True
B) False ✅✅ANSW-true
A patient (11 yo) is prescribed imipenem IV for a gram-negative bacterial infection. Imipenem
overdose can cause seizure and other CNS adverse effects, especially in patients with CNS disorders
and/or compromised renal function. Imipenem dosage needs to be adjusted based on calculated
CrCl or GFR. Which formula would be most appropriate in this case to calculate CrCl or GFR?
A) MDRD formula
B) Schwartz formula or Counahan-Barratt formula
C) Cockcroft-Gault equation
D) 24-hour urine collection method ✅✅ANSW-Schwartz formula or Counahan-Barratt formula
The inulin clearance rate is equal to the GFR because inulin is completely filtered through the
glomerulus and not metabolized, not secreted or reabsorbed at kidney tubules.
A) True
B) False ✅✅ANSW-True
Drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to an
elevated serum creatinine concentration without any damage to renal function. These drugs include:
A) cimetidine and probenecid
B) acetaminophen and ibuprofen
C) fexonfenadine and loratidine
D) warfarin and sildenafil ✅✅ANSW-A) cimetidine and probenecid
Which of the following is NOT true about the creatinine renal function test?
A) increased body muscle mass does not significantly change SCr
B) SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method
, C) Creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as creatine
phosphate. Creatinine is produced by cyclization of creatine and then escape muscle cell membrane
into blood.
D) Body fat does not affect SCr level. ✅✅ANSW-A) Increased body muscle mass does not
significantly change SCr
Which of the following is NOT true about kidney glomerulus?
A) GFR reflects kidney function and disease
B) Most small molecule drugs are filtered at glomerulus, except for drugs bound to plasma protein
C) Protein biologics, e.g., monoclonal antibodies (mAbs), are filtered at glomerulus
D) Filter substances with molecular weight <40,000 Da ✅✅ANSW-C) Protein biologics, e.g.,
monoclonal antibodies (mAbs), are filtered at glomerulus
During dipstick urinalysis, normal urine should not contain the following substances except for:
A) Sodium and Potassium
B) Glucose
C) Protein
D) Albumin and Hemoglobin ✅✅ANSW-A) sodium and potassium
Which drug can turn urine into a red to orange color?
A) Chloroquine
B) Amitriptyline
C) Doxorubicin ✅✅ANSW-Doxorubicin
Creatinine clearance is inversely related to the serum concentration.
A) True
B) False ✅✅ANSW-True
Which of the following methods/assays is NOT used to determine creatinine serum concentration?
A) immunoassay (detect using antibodies against creatinine)
B) Jaffe Reaction (reaction of creatinine with piric acid to form red-orange complex)
AND CORRECT ANSWERS
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost completely
filtered by the glomerulus, approximately 50% of the filtered urea is re-absorbed in the kidney
tubules.
A) True
B) False ✅✅ANSW-true
A patient (11 yo) is prescribed imipenem IV for a gram-negative bacterial infection. Imipenem
overdose can cause seizure and other CNS adverse effects, especially in patients with CNS disorders
and/or compromised renal function. Imipenem dosage needs to be adjusted based on calculated
CrCl or GFR. Which formula would be most appropriate in this case to calculate CrCl or GFR?
A) MDRD formula
B) Schwartz formula or Counahan-Barratt formula
C) Cockcroft-Gault equation
D) 24-hour urine collection method ✅✅ANSW-Schwartz formula or Counahan-Barratt formula
The inulin clearance rate is equal to the GFR because inulin is completely filtered through the
glomerulus and not metabolized, not secreted or reabsorbed at kidney tubules.
A) True
B) False ✅✅ANSW-True
Drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to an
elevated serum creatinine concentration without any damage to renal function. These drugs include:
A) cimetidine and probenecid
B) acetaminophen and ibuprofen
C) fexonfenadine and loratidine
D) warfarin and sildenafil ✅✅ANSW-A) cimetidine and probenecid
Which of the following is NOT true about the creatinine renal function test?
A) increased body muscle mass does not significantly change SCr
B) SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method
, C) Creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as creatine
phosphate. Creatinine is produced by cyclization of creatine and then escape muscle cell membrane
into blood.
D) Body fat does not affect SCr level. ✅✅ANSW-A) Increased body muscle mass does not
significantly change SCr
Which of the following is NOT true about kidney glomerulus?
A) GFR reflects kidney function and disease
B) Most small molecule drugs are filtered at glomerulus, except for drugs bound to plasma protein
C) Protein biologics, e.g., monoclonal antibodies (mAbs), are filtered at glomerulus
D) Filter substances with molecular weight <40,000 Da ✅✅ANSW-C) Protein biologics, e.g.,
monoclonal antibodies (mAbs), are filtered at glomerulus
During dipstick urinalysis, normal urine should not contain the following substances except for:
A) Sodium and Potassium
B) Glucose
C) Protein
D) Albumin and Hemoglobin ✅✅ANSW-A) sodium and potassium
Which drug can turn urine into a red to orange color?
A) Chloroquine
B) Amitriptyline
C) Doxorubicin ✅✅ANSW-Doxorubicin
Creatinine clearance is inversely related to the serum concentration.
A) True
B) False ✅✅ANSW-True
Which of the following methods/assays is NOT used to determine creatinine serum concentration?
A) immunoassay (detect using antibodies against creatinine)
B) Jaffe Reaction (reaction of creatinine with piric acid to form red-orange complex)
