PHCH 667 EXAM 1 QUESTIONS AND
ANSWERS
1. Predictive value for a positive Qualitative Test is best describes as:
a. both answers are correct
b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed positive values
c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed negative values
✅✅ANSW-b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed
positive values
2. There are two kindergarten classes from different parts of a city in which five boys (5 years of age)
were randomly selected to see how their weights compared to the national average of boys this age,
which is 41 pounds. Below are the data for the selective five boys from each of the two classes:
Class 1: 34, 38, 52, 42 and 34 pounds
Class 2: 40, 44, 40, 38 and 38 pounds
Which class provides a more precise representation of the weight of this class of 5 year old boys?
a. Class 1
b. Class 2
c. They are equally accurate ✅✅ANSW-b. Class 2
3. For a Qualitative Test, sensitivity is determined by:
a. TP/(TP+FP) - the number of true positives divided by all positive results seen by the test
b. TP/(TP+FN) - the number of true positives divided by all results that should have been positive
✅✅ANSW-b. TP/(TP+FN) - the number of true positives divided by all results that should have
been positive
,4. Precision is best represented by which of the following?
a. Variance
b. Standard deviation
c. Mean (average)
d. Gaussian distribution ✅✅ANSW-b. Standard deviation
5. Predictive value for a negative Qualitative Test is best describes as:
a. both answers are correct
b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed positive values
c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed negative values
✅✅ANSW-c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed
negative values
6. Accuracy is best represented by which of the following?
a. Standard deviation
b. Variance
c. Gaussian distribution
d. Mean (average) ✅✅ANSW-d. Mean (average)
7. For a Qualitative Test, specificity is determined by:
a. TN/(TN+FP) - the number of true negatives divided by all results that should have been negative
b. TN/(TP+FN) - the number of true negatives divided by all the true positive and negative values
✅✅ANSW-a. TN/(TN+FP) - the number of true negatives divided by all results that should have
been negative
8. There are two kindergarten classes from different parts of a city in which five boys (5 years of age)
were randomly selected to see how their weights compared to the national average of boys this age,
which is 41 pounds. Below are the data for the selective five boys from each of the two classes:
, Class 1: 34, 38, 52, 42 and 34 pounds
Class 2: 40, 44, 40, 38 and 38 pounds
Which class provides a more accurate representation of the weight of this class of 5 year old boys?
a. Class 1
b. Class 2
c. They are equally accurate ✅✅ANSW-b. Class 2
1. Which is the correct definition of international unit for enzyme activity?
a. Amount of enzyme that catalyzes the conversion of one kilogram of substrate in 1 h
b. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1 minute
c. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1 h
d. Amount of enzyme that catalyzes the conversion of one milligram of substrate in 1 minute
✅✅ANSW-b. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1
minute
2. What analytes are separated on agarose gel and SDS-PAGE, respectively?
a. Lipids and protein
b. Proteins and DNA
c. DNA and RNA
d. DNA and protein ✅✅ANSW-d. DNA and protein
3. Enzyme-based clinical assays can be used to measure both endogenous enzymes and endogenous
substrates.
a. True
b. False ✅✅ANSW-a. True
ANSWERS
1. Predictive value for a positive Qualitative Test is best describes as:
a. both answers are correct
b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed positive values
c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed negative values
✅✅ANSW-b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed
positive values
2. There are two kindergarten classes from different parts of a city in which five boys (5 years of age)
were randomly selected to see how their weights compared to the national average of boys this age,
which is 41 pounds. Below are the data for the selective five boys from each of the two classes:
Class 1: 34, 38, 52, 42 and 34 pounds
Class 2: 40, 44, 40, 38 and 38 pounds
Which class provides a more precise representation of the weight of this class of 5 year old boys?
a. Class 1
b. Class 2
c. They are equally accurate ✅✅ANSW-b. Class 2
3. For a Qualitative Test, sensitivity is determined by:
a. TP/(TP+FP) - the number of true positives divided by all positive results seen by the test
b. TP/(TP+FN) - the number of true positives divided by all results that should have been positive
✅✅ANSW-b. TP/(TP+FN) - the number of true positives divided by all results that should have
been positive
,4. Precision is best represented by which of the following?
a. Variance
b. Standard deviation
c. Mean (average)
d. Gaussian distribution ✅✅ANSW-b. Standard deviation
5. Predictive value for a negative Qualitative Test is best describes as:
a. both answers are correct
b. PPV = TP/(TP+FP) - the number of a true positive values divided by all observed positive values
c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed negative values
✅✅ANSW-c. NPV = TN/(TN+FN) - the number of true negative values divided by all observed
negative values
6. Accuracy is best represented by which of the following?
a. Standard deviation
b. Variance
c. Gaussian distribution
d. Mean (average) ✅✅ANSW-d. Mean (average)
7. For a Qualitative Test, specificity is determined by:
a. TN/(TN+FP) - the number of true negatives divided by all results that should have been negative
b. TN/(TP+FN) - the number of true negatives divided by all the true positive and negative values
✅✅ANSW-a. TN/(TN+FP) - the number of true negatives divided by all results that should have
been negative
8. There are two kindergarten classes from different parts of a city in which five boys (5 years of age)
were randomly selected to see how their weights compared to the national average of boys this age,
which is 41 pounds. Below are the data for the selective five boys from each of the two classes:
, Class 1: 34, 38, 52, 42 and 34 pounds
Class 2: 40, 44, 40, 38 and 38 pounds
Which class provides a more accurate representation of the weight of this class of 5 year old boys?
a. Class 1
b. Class 2
c. They are equally accurate ✅✅ANSW-b. Class 2
1. Which is the correct definition of international unit for enzyme activity?
a. Amount of enzyme that catalyzes the conversion of one kilogram of substrate in 1 h
b. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1 minute
c. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1 h
d. Amount of enzyme that catalyzes the conversion of one milligram of substrate in 1 minute
✅✅ANSW-b. Amount of enzyme that catalyzes the conversion of one micromole of substrate in 1
minute
2. What analytes are separated on agarose gel and SDS-PAGE, respectively?
a. Lipids and protein
b. Proteins and DNA
c. DNA and RNA
d. DNA and protein ✅✅ANSW-d. DNA and protein
3. Enzyme-based clinical assays can be used to measure both endogenous enzymes and endogenous
substrates.
a. True
b. False ✅✅ANSW-a. True
