PHCH 667 INTRODUCTION TO
CLINICAL CHEMISTRY EXAM 1
How do we understand the likelihood that the results of a given test are valid? ✅✅ANSW-
through statistics!
why is statistics used in clinical chemistry? ✅✅ANSW-determination of "normal range" and
validity of a test
what are the assay parameters for quantitative tests? ✅✅ANSW-• Accuracy
• Precision
• Reference values
• Critical value
what are the assay parameters for qualitative tests? ✅✅ANSW-• Sensitivity
• Specificity
• Predictive value
• Accuracy
give four examples of quantitative clinical chemistry tests. ✅✅ANSW-• ion-selective electrodes
• colorimetric assays
• immunoassays
• monitors based on enzyme rxns
what does accuracy mean in relation to quantitative tests and how is it calculated statistically?
✅✅ANSW-•Degree of correlation of results between assay
being investigated and the true value.
• Statistics: Mean
what is the purpose of clinical chemistry? ✅✅ANSW-Molecular indicators of health status or
disease - at the interface between biochemistry and medicine
, What are the 6 rationales behind laboratory tests done in clinical chemistry? ✅✅ANSW-•
Diagnosis of disease
• Confirm diagnosis after signs and symptoms appear
• Differentially diagnosing possible diseases
• Determining stage or activity level of the disease
• Detecting the recurrence of a disease
• Measuring the effectiveness of therapy and guiding its course
analyte ✅✅ANSW-substance measured by the assay
biomarker ✅✅ANSW-characteristic that is objectivity measured and evaluated as an indicator of
normal biological processes, pathogenic processes or pharmacological responses to therapeutic
intervention
specimen (you should know this already) ✅✅ANSW-Sample used for laboratory analysis
what to categories do clinical laboratory tests fall into? ✅✅ANSW-qualitative and quantitative
quantitative test ✅✅ANSW-gives a number (generally a concentration or activity)
qualitative ✅✅ANSW-Yes or No answer
what does precision mean in relation to quantitative tests and how is it calculated statistically?
✅✅ANSW-• Degree of variability of assay results when known specimens are tested repeatedly in
one run or over several days
• Statistics: Standard deviation
A patient weighs 120 lbs, she obtains the following weights from two different scales:
Scale 1:
120
122
CLINICAL CHEMISTRY EXAM 1
How do we understand the likelihood that the results of a given test are valid? ✅✅ANSW-
through statistics!
why is statistics used in clinical chemistry? ✅✅ANSW-determination of "normal range" and
validity of a test
what are the assay parameters for quantitative tests? ✅✅ANSW-• Accuracy
• Precision
• Reference values
• Critical value
what are the assay parameters for qualitative tests? ✅✅ANSW-• Sensitivity
• Specificity
• Predictive value
• Accuracy
give four examples of quantitative clinical chemistry tests. ✅✅ANSW-• ion-selective electrodes
• colorimetric assays
• immunoassays
• monitors based on enzyme rxns
what does accuracy mean in relation to quantitative tests and how is it calculated statistically?
✅✅ANSW-•Degree of correlation of results between assay
being investigated and the true value.
• Statistics: Mean
what is the purpose of clinical chemistry? ✅✅ANSW-Molecular indicators of health status or
disease - at the interface between biochemistry and medicine
, What are the 6 rationales behind laboratory tests done in clinical chemistry? ✅✅ANSW-•
Diagnosis of disease
• Confirm diagnosis after signs and symptoms appear
• Differentially diagnosing possible diseases
• Determining stage or activity level of the disease
• Detecting the recurrence of a disease
• Measuring the effectiveness of therapy and guiding its course
analyte ✅✅ANSW-substance measured by the assay
biomarker ✅✅ANSW-characteristic that is objectivity measured and evaluated as an indicator of
normal biological processes, pathogenic processes or pharmacological responses to therapeutic
intervention
specimen (you should know this already) ✅✅ANSW-Sample used for laboratory analysis
what to categories do clinical laboratory tests fall into? ✅✅ANSW-qualitative and quantitative
quantitative test ✅✅ANSW-gives a number (generally a concentration or activity)
qualitative ✅✅ANSW-Yes or No answer
what does precision mean in relation to quantitative tests and how is it calculated statistically?
✅✅ANSW-• Degree of variability of assay results when known specimens are tested repeatedly in
one run or over several days
• Statistics: Standard deviation
A patient weighs 120 lbs, she obtains the following weights from two different scales:
Scale 1:
120
122
