CHAMBERLAIN NR507 MIDTERM EXAM /
STUDY GUIDE ACTUAL LATEST VERSION 2025-
2026 /QUESTIONS AND CORRECT ANSWERS /
A GRADE SCORE SOLUTION.
Terms in this set (63)
Type 1 Hypersensitivity - "Allergic reaction"- Mediated by IgE.
Reaction - Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
- Local s/s: itching, rash.
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension,severe
bronchoconstriction.
- Main tx: epinephrine.
Type 2 Hypersensitivity - Cytotoxic reaction; tissue specific
Reaction - Macrophages are the primary effectors cellsinvolved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of alteringthyroid
function, doesn't destroy thyroid tissue. 2) ABO incompatibility-
example of cell/tissue damage; severe transfusion reaction
occurs & the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
, - Type 2: organ specific; antibody binds to the antigenon the
Difference between type 2 cell surface.
& 3 hypersensitivity - Type 3: not organ specific; antibody binds to solubleantigen
reactions outside the cell surface that was released into the blood or
body fluids, and the complex is then deposited in the tissues.
Type 3 Hypersensitivity - Immune complex
Reaction - Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
- Causes autoimmune diseases
- Examples: rheumatoid arthritis (joints), systemiclupus
erythematosus (SLE, organs)
Systemic Lupus - Facial rash confined to the cheeks (malar rash)
Erythematosus (SLE) - Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,leukopenia,
lymphopenia, thrombocytopenia)
- Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
Autoimmunity - Can be familial: Affected family members may not all develop
the same disease, but several members may have different
disorders characterized by a variety of hypersensitivity reactions
(autoimmune and allergic reactions).
STUDY GUIDE ACTUAL LATEST VERSION 2025-
2026 /QUESTIONS AND CORRECT ANSWERS /
A GRADE SCORE SOLUTION.
Terms in this set (63)
Type 1 Hypersensitivity - "Allergic reaction"- Mediated by IgE.
Reaction - Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
- Local s/s: itching, rash.
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension,severe
bronchoconstriction.
- Main tx: epinephrine.
Type 2 Hypersensitivity - Cytotoxic reaction; tissue specific
Reaction - Macrophages are the primary effectors cellsinvolved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of alteringthyroid
function, doesn't destroy thyroid tissue. 2) ABO incompatibility-
example of cell/tissue damage; severe transfusion reaction
occurs & the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
, - Type 2: organ specific; antibody binds to the antigenon the
Difference between type 2 cell surface.
& 3 hypersensitivity - Type 3: not organ specific; antibody binds to solubleantigen
reactions outside the cell surface that was released into the blood or
body fluids, and the complex is then deposited in the tissues.
Type 3 Hypersensitivity - Immune complex
Reaction - Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
- Causes autoimmune diseases
- Examples: rheumatoid arthritis (joints), systemiclupus
erythematosus (SLE, organs)
Systemic Lupus - Facial rash confined to the cheeks (malar rash)
Erythematosus (SLE) - Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,leukopenia,
lymphopenia, thrombocytopenia)
- Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
Autoimmunity - Can be familial: Affected family members may not all develop
the same disease, but several members may have different
disorders characterized by a variety of hypersensitivity reactions
(autoimmune and allergic reactions).
