GMS 6540 ACTUAL TEST PAPER 2025/2026 QUESTIONS
WITH SOLUTIONS GRADED A+
✔✔Osimertinib - ✔✔- inhibits T790M EGFR
- rash, diarrhea
✔✔Trastuzumab - ✔✔- Antibody HER2/Neu Inhibitor
- used in HER2 breast cancer and gastric cancers
- cardiotoxicity in some (increased with doxorubicin)
✔✔Lapatinib, - ✔✔- HER2 Kinase Inhibitor (Inhibit both Her2 and EGFR)
- oral admin
- Used with or after trastuzumab
✔✔Olaratumab - ✔✔Blocks PDGF binding
✔✔Hormone dependent cancers - ✔✔breast, prostate, lymphoma
✔✔Tamoxifen - ✔✔- competitive inhibitor of estrogen
-orginally developed as birth control, used to treat breast cancer after tumor removal or
prophylactively
- increases endometrial cancer risk
✔✔Raloxifene - ✔✔- used for breast cancer prevention in postmenopausal women
- 3x greater risk of deep vein thrombosis
✔✔Fulvestant - ✔✔- only SERD
- IM dosing
- binds to ER and causes proteasomal degradation
- 2nd line for HER2+ cancer
- few side effects vs SERM
✔✔Anastrozole - ✔✔- competitive aromatase inhibitor
- only used postmenopause
- works better than tamoxifen
✔✔Enzalutamide - ✔✔- androgen receptor antagonist
✔✔Lymphoma - ✔✔- use glucocorticoids
✔✔External Beam Radiation Therapy (Teletherapy) - ✔✔- most common
- uses X-Rays
✔✔brachytherapy (internal radiation therapy) - ✔✔- radiated Seeds, rods or wires
, ✔✔Radiosurgery - ✔✔- Use multiple beams to target the tumor
-mostly used in brain cancer
✔✔Radio-sensitive stages in the cell cycle - ✔✔G2 & M
✔✔block IL2 production - ✔✔Cyclosporine, Tacrolimus/FK506- Calcineurin inhibitors
✔✔blocks T cell proliferation - ✔✔Sirolimus- mTOR inhibitor
✔✔suppresses cytokine production - ✔✔Prednisone- synthetic steroid
✔✔alkylating agent; kills dividing cells - ✔✔Cyclophosphamide
✔✔Antimetabolite; kills dividing cells - ✔✔Mycophenolate Mofetil & methotrexate
✔✔Antibody recognizing the CD20 B cell marker - ✔✔Rituximab, used to treat
lymphomas, RA, and MS
✔✔TNFa neutralizing antibody - ✔✔Inflixumab, used in RA and Crohns
✔✔IL6 receptor neutralizing antibody - ✔✔Tocilizumab, used in RA
✔✔Neutralizing antibody to the IL2 receptor - ✔✔Daclizumab, used in transplant
rejection
✔✔Rh(D) immune globulin used to prevent hemolytic disease - ✔✔RHOGAM
✔✔CD3 (OKT-3) - ✔✔Muromonab, used in transplant rejection
✔✔Immunosuppressant with hyperlipidemia as a side effect - ✔✔Sirolimus
✔✔suffix ~omab - ✔✔Murine monoclonal antibodies
✔✔suffix ~ ximab, ~zumab - ✔✔Chimeric and humanized monoclonal antibodies
✔✔suffix ~ mumab - ✔✔Human monoclonal antibodies
✔✔Bactericidal drugs - ✔✔- B-lactams
- vancomycin
- fluoroquinolones
- aminoglycosides
- TB drugs
WITH SOLUTIONS GRADED A+
✔✔Osimertinib - ✔✔- inhibits T790M EGFR
- rash, diarrhea
✔✔Trastuzumab - ✔✔- Antibody HER2/Neu Inhibitor
- used in HER2 breast cancer and gastric cancers
- cardiotoxicity in some (increased with doxorubicin)
✔✔Lapatinib, - ✔✔- HER2 Kinase Inhibitor (Inhibit both Her2 and EGFR)
- oral admin
- Used with or after trastuzumab
✔✔Olaratumab - ✔✔Blocks PDGF binding
✔✔Hormone dependent cancers - ✔✔breast, prostate, lymphoma
✔✔Tamoxifen - ✔✔- competitive inhibitor of estrogen
-orginally developed as birth control, used to treat breast cancer after tumor removal or
prophylactively
- increases endometrial cancer risk
✔✔Raloxifene - ✔✔- used for breast cancer prevention in postmenopausal women
- 3x greater risk of deep vein thrombosis
✔✔Fulvestant - ✔✔- only SERD
- IM dosing
- binds to ER and causes proteasomal degradation
- 2nd line for HER2+ cancer
- few side effects vs SERM
✔✔Anastrozole - ✔✔- competitive aromatase inhibitor
- only used postmenopause
- works better than tamoxifen
✔✔Enzalutamide - ✔✔- androgen receptor antagonist
✔✔Lymphoma - ✔✔- use glucocorticoids
✔✔External Beam Radiation Therapy (Teletherapy) - ✔✔- most common
- uses X-Rays
✔✔brachytherapy (internal radiation therapy) - ✔✔- radiated Seeds, rods or wires
, ✔✔Radiosurgery - ✔✔- Use multiple beams to target the tumor
-mostly used in brain cancer
✔✔Radio-sensitive stages in the cell cycle - ✔✔G2 & M
✔✔block IL2 production - ✔✔Cyclosporine, Tacrolimus/FK506- Calcineurin inhibitors
✔✔blocks T cell proliferation - ✔✔Sirolimus- mTOR inhibitor
✔✔suppresses cytokine production - ✔✔Prednisone- synthetic steroid
✔✔alkylating agent; kills dividing cells - ✔✔Cyclophosphamide
✔✔Antimetabolite; kills dividing cells - ✔✔Mycophenolate Mofetil & methotrexate
✔✔Antibody recognizing the CD20 B cell marker - ✔✔Rituximab, used to treat
lymphomas, RA, and MS
✔✔TNFa neutralizing antibody - ✔✔Inflixumab, used in RA and Crohns
✔✔IL6 receptor neutralizing antibody - ✔✔Tocilizumab, used in RA
✔✔Neutralizing antibody to the IL2 receptor - ✔✔Daclizumab, used in transplant
rejection
✔✔Rh(D) immune globulin used to prevent hemolytic disease - ✔✔RHOGAM
✔✔CD3 (OKT-3) - ✔✔Muromonab, used in transplant rejection
✔✔Immunosuppressant with hyperlipidemia as a side effect - ✔✔Sirolimus
✔✔suffix ~omab - ✔✔Murine monoclonal antibodies
✔✔suffix ~ ximab, ~zumab - ✔✔Chimeric and humanized monoclonal antibodies
✔✔suffix ~ mumab - ✔✔Human monoclonal antibodies
✔✔Bactericidal drugs - ✔✔- B-lactams
- vancomycin
- fluoroquinolones
- aminoglycosides
- TB drugs
