MSN 621 - Hem/Onc Quiz- Questions and Answers| Latest
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A 49-year-old male with fatigue and easy bruising is found to have terminal deoxynucleotidyl
transferase (TdT) positive cells in the blood. He may have which of the following conditions?]
A. Acute myelogenous leukemia
B. Hodgkin lymphoma
C. Hairy cell leukemia
D. Acute lymphoblastic leukemia D. Acute lymphoblastic leukemia
A 16-year-old male presents with fatigue, easy bruisability, and weight loss. On examination,
hepatosplenomegaly is noted. After a detailed evaluation, the patient is diagnosed with acute
lymphocytic leukemia. Which of the following is used in the management of this patient's
condition?
A. Dexarazoxane
B. L-asparaginase
C. Imatinib
D. Everolimus B. L-asparaginase
A 16-year-old male presents with lethargy, fatigue, and occasional mucosal bleeding. The
patient also reports weight loss in the past 5 months. Laboratory analysis reveals a white blood
cell count of 32,000 cells/microL. On examination, hepatosplenomegaly is noted. Further
evaluation shows findings suggestive of acute lymphocytic leukemia. What is the most likely
cause of the patient's mucosal bleeding?
A. Hepatosplenomegaly
, B. Decreased platelet count
C. Factor V Deficiency
D. Microthrombi formation B. Decreased platelet count
A 59-year-old male patient with a history of non-Hodgkins lymphoma treated with
cyclophosphamide, adriamycin, vincristine, and prednisone eight years ago presents with a new
diagnosis of myelodysplastic syndrome. Bone marrow biopsy reveals 12% blasts and greater
than 10% dysplasia in the erythroid and granulocytic lineages. Fluorescence in situ hybridization
(FISH) revealed monosomy 7. He asks you about the risk of transformation into acute myeloid
leukemia (AML). What is the risk of treatment-related myelodysplastic syndrome transforming
into AML?
A. 50% of patients will transform into AML
B. 2% of patients will transform into AML
C. 10% of patients will transform into AML
D. There is no risk of transformation into AML A. 50% of patients will transform into AML
A 67-year-old female with a performance status of 0, is brought to the clinic with symptomatic
anemia and has required several transfusions over the past 2 to 3 months. Currently, her
hemoglobin is 7.5 g/dL, absolute neutrophil count 1500/microL and platelet count is
119,000/microL. She had a bone marrow biopsy performed that reveals myelodysplastic
syndrome (MDS) with 6% blasts and cytogenetics positive for 5q deletion. She did not have any
mutations or other cytogenetic abnormalities. Which of the following is the best initial course of
treatment?
A. An erythropoietin stimulating agent
B. A thalidomide derivative
C. A hypomethylating agent
D. Stem cell transplant B. A thalidomide derivative
Update 100% Verified
A 49-year-old male with fatigue and easy bruising is found to have terminal deoxynucleotidyl
transferase (TdT) positive cells in the blood. He may have which of the following conditions?]
A. Acute myelogenous leukemia
B. Hodgkin lymphoma
C. Hairy cell leukemia
D. Acute lymphoblastic leukemia D. Acute lymphoblastic leukemia
A 16-year-old male presents with fatigue, easy bruisability, and weight loss. On examination,
hepatosplenomegaly is noted. After a detailed evaluation, the patient is diagnosed with acute
lymphocytic leukemia. Which of the following is used in the management of this patient's
condition?
A. Dexarazoxane
B. L-asparaginase
C. Imatinib
D. Everolimus B. L-asparaginase
A 16-year-old male presents with lethargy, fatigue, and occasional mucosal bleeding. The
patient also reports weight loss in the past 5 months. Laboratory analysis reveals a white blood
cell count of 32,000 cells/microL. On examination, hepatosplenomegaly is noted. Further
evaluation shows findings suggestive of acute lymphocytic leukemia. What is the most likely
cause of the patient's mucosal bleeding?
A. Hepatosplenomegaly
, B. Decreased platelet count
C. Factor V Deficiency
D. Microthrombi formation B. Decreased platelet count
A 59-year-old male patient with a history of non-Hodgkins lymphoma treated with
cyclophosphamide, adriamycin, vincristine, and prednisone eight years ago presents with a new
diagnosis of myelodysplastic syndrome. Bone marrow biopsy reveals 12% blasts and greater
than 10% dysplasia in the erythroid and granulocytic lineages. Fluorescence in situ hybridization
(FISH) revealed monosomy 7. He asks you about the risk of transformation into acute myeloid
leukemia (AML). What is the risk of treatment-related myelodysplastic syndrome transforming
into AML?
A. 50% of patients will transform into AML
B. 2% of patients will transform into AML
C. 10% of patients will transform into AML
D. There is no risk of transformation into AML A. 50% of patients will transform into AML
A 67-year-old female with a performance status of 0, is brought to the clinic with symptomatic
anemia and has required several transfusions over the past 2 to 3 months. Currently, her
hemoglobin is 7.5 g/dL, absolute neutrophil count 1500/microL and platelet count is
119,000/microL. She had a bone marrow biopsy performed that reveals myelodysplastic
syndrome (MDS) with 6% blasts and cytogenetics positive for 5q deletion. She did not have any
mutations or other cytogenetic abnormalities. Which of the following is the best initial course of
treatment?
A. An erythropoietin stimulating agent
B. A thalidomide derivative
C. A hypomethylating agent
D. Stem cell transplant B. A thalidomide derivative
