BMS 411A: Bioinformatics and its applications
A group work assignment II
Submitted to
Dr. Monica Opiyo
By group c members:
Calvin Nyamira 17-0065 (group leader)
Francis Gitonga 17-0053
Vincent Abiero 17-0066
Nicolas Koech 17-0118
Department of Science
School of Science, Engineering and Health
29th October, 2020
, QUESTION ONE
In detail describe what Genomic Mapping is all about and how it has helped in clinical
science (60mks)
Introduction
Genetic mapping is the localization within the genome of genes underlying a disease on the basis
of correlation with DNA variation, without the need for prior hypotheses as opposite to the
candidate gene approach.
A genome map helps scientists navigate around the genome. Like road maps and other familiar
maps, a genome map is a set of landmarks that tells people where they are, and helps them get
where they want to go.
The landmarks on a genome map might include short DNA sequences, regulatory sites that turn
genes on and off, and genes themselves. Often, genome maps are used to help scientists find new
genes.
Some parts of the genome have been mapped in great detail, while others remain relatively
uncharted territory. It may turn out that a few landmarks on current genome maps appear in the
wrong place or at the wrong distance from other landmarks. But over time, as scientists continue
to explore the genome frontier, maps will become more accurate and more detailed.
How it has helped in clinical science.
Genome maps help scientists find genes, particularly those involved in human disease. This
process is much like a scientific game of hot and cold. Scientists study many families affected by
a disease, tracing the inheritance of the disease and of specific genome landmarks through several
generations. Landmarks that tend to be inherited along with the disease are likely to be located
close to the disease gene and become "markers" for the gene in question.
A group work assignment II
Submitted to
Dr. Monica Opiyo
By group c members:
Calvin Nyamira 17-0065 (group leader)
Francis Gitonga 17-0053
Vincent Abiero 17-0066
Nicolas Koech 17-0118
Department of Science
School of Science, Engineering and Health
29th October, 2020
, QUESTION ONE
In detail describe what Genomic Mapping is all about and how it has helped in clinical
science (60mks)
Introduction
Genetic mapping is the localization within the genome of genes underlying a disease on the basis
of correlation with DNA variation, without the need for prior hypotheses as opposite to the
candidate gene approach.
A genome map helps scientists navigate around the genome. Like road maps and other familiar
maps, a genome map is a set of landmarks that tells people where they are, and helps them get
where they want to go.
The landmarks on a genome map might include short DNA sequences, regulatory sites that turn
genes on and off, and genes themselves. Often, genome maps are used to help scientists find new
genes.
Some parts of the genome have been mapped in great detail, while others remain relatively
uncharted territory. It may turn out that a few landmarks on current genome maps appear in the
wrong place or at the wrong distance from other landmarks. But over time, as scientists continue
to explore the genome frontier, maps will become more accurate and more detailed.
How it has helped in clinical science.
Genome maps help scientists find genes, particularly those involved in human disease. This
process is much like a scientific game of hot and cold. Scientists study many families affected by
a disease, tracing the inheritance of the disease and of specific genome landmarks through several
generations. Landmarks that tend to be inherited along with the disease are likely to be located
close to the disease gene and become "markers" for the gene in question.
