NAPLEX PREP QUESTIONS
Name three examples of at-home tests that can be purchased OTC? - Answer-pregnancy, ovulation, HIV,
herpes, fecal occult blood, drug tests
lifespan of platelets? - Answer-7-10 days -- reason you have to hold aspirin 10 days prior to surgery
When would a CMP be helpful? - Answer-getting baseline electrolyte labs and liver function tests in one
blood draw
These are the three white blood cells (leukocytes) classified further as granulocytes - Answer-
neutrophils, basophils, eosinophils
Drug-induced agranulocytosis caused by what drugs? - Answer-clozapine, propylthiouracil, methimazole,
procainamide, carbamazepine, bactrim, isoniazid
For what lab values does JCO require a specific institution protocol? - Answer-critical lab values and in
that protocol, physicians are required to have a time frame to manage them
Define "myelosuppression" - Answer-a reduction in all hematopoietic cells (RBCs, platelets, leukocytes)
,What medications increase serum calcium ? - Answer-vitamin D, thiazides
What medications DECREASE serum calcium? - Answer-corticosteroids, long-term heparin, loops,
bisphosphonates, cinacalcet, topiramate, calcitonin
T/F You must correct calcium every time you get a value for serum calcium. - Answer-False, ionized
calcium does not need to be corrected.
Corrected Ca = Reported Ca + [(4-albumin) x 0.8]
What medications / disease states lower serum magnesium?
normal 1.3-2.1 mEq/L - Answer-PPIs, diuretics, amphoB, echinocandins
Diarrhea, chronic alcohol use disorder
What medications elevate serum magnesium?
normal 1.3-2.1 mEq/L - Answer-Mg-containing antacids, laxatives in renal impairment
Phosphate levels (normal 2.3-4.7 mg/L) in the blood can be lowered by... - Answer-phosphate binders,
oral Calcium
Role of PO4 in the body... - Answer-in bone metabolism, helps to buffer acid-base balance
Electrolyte imbalances/ changes resulting from renal impairment are: - Answer-increased phosphate
increased BUN
increased Scr
,Main intracellular cation that's normal range is 3.5-5mEq/L? - Answer-potassium
Elevate or reduce serum concentrations of potassium?
A. Corticosteroids
B. ACEi/ARBs/aliskerin
C. Canagliflozin
D. Albuterol
E. Loops
F. Insulin
G. Bactrim
H. Immunosuppressives (cyclosporine/ tacrolimus) - Answer-A. lower
B. elevate
C. elevate
D. lower
E. lower
F. lower
G. elevate
H. elevate
Medications that reduce extracellular sodium concentrations (normal 135-145mEq/L) - Answer-
carbamazepine, oxcarbazepine, SSRIs, diuretics
How does a salicylate overdose affect the body's acid-base balance? - Answer-body enters alkalosis
When the anion gap is elevated above 5-12 normal range, what is the body's metabolic state? - Answer-
metabolic acidosis
, A 4 year old gets a new prescription for an antibiotic and her mother is asking you if it's appropriately
dosed. What references could you refer to check? - Answer-Harriet Lane Handbook
Red Book by AAP
You get a call from a Dr. about to discharge a patient from the hospital who just had a GI ulcer bleed.
The doctor is asking what formulations are available for this patient's maintenance medications because
he is afraid oral tablets will be too harsh. What references do you check? - Answer-Package inserts
Any drug monograph - Lexi, Micromedex, ClinPharm, Facts and Comparisons
A very concerned father rushes into your pharmacy after finding a small white pill on his daughter's
bedroom floor. He asks you to identify the medication. How would you go about doing this if you didn't
recognize the tablet? - Answer-Use the Drug ID tool on Micromedex, Lexicomp, Pillbox, Ident-A-Drug
**only source without pill ID = AHFS
Which of the following are included in the package insert?
A. Indications
B. Black box warnings
C. Drug cost
D. Major changes in safety
E. Dosing administration
F. Drug strengths and formulations
G. ADRs and DDIs
H. Mechanism of Action
I. Contraindications
Name three examples of at-home tests that can be purchased OTC? - Answer-pregnancy, ovulation, HIV,
herpes, fecal occult blood, drug tests
lifespan of platelets? - Answer-7-10 days -- reason you have to hold aspirin 10 days prior to surgery
When would a CMP be helpful? - Answer-getting baseline electrolyte labs and liver function tests in one
blood draw
These are the three white blood cells (leukocytes) classified further as granulocytes - Answer-
neutrophils, basophils, eosinophils
Drug-induced agranulocytosis caused by what drugs? - Answer-clozapine, propylthiouracil, methimazole,
procainamide, carbamazepine, bactrim, isoniazid
For what lab values does JCO require a specific institution protocol? - Answer-critical lab values and in
that protocol, physicians are required to have a time frame to manage them
Define "myelosuppression" - Answer-a reduction in all hematopoietic cells (RBCs, platelets, leukocytes)
,What medications increase serum calcium ? - Answer-vitamin D, thiazides
What medications DECREASE serum calcium? - Answer-corticosteroids, long-term heparin, loops,
bisphosphonates, cinacalcet, topiramate, calcitonin
T/F You must correct calcium every time you get a value for serum calcium. - Answer-False, ionized
calcium does not need to be corrected.
Corrected Ca = Reported Ca + [(4-albumin) x 0.8]
What medications / disease states lower serum magnesium?
normal 1.3-2.1 mEq/L - Answer-PPIs, diuretics, amphoB, echinocandins
Diarrhea, chronic alcohol use disorder
What medications elevate serum magnesium?
normal 1.3-2.1 mEq/L - Answer-Mg-containing antacids, laxatives in renal impairment
Phosphate levels (normal 2.3-4.7 mg/L) in the blood can be lowered by... - Answer-phosphate binders,
oral Calcium
Role of PO4 in the body... - Answer-in bone metabolism, helps to buffer acid-base balance
Electrolyte imbalances/ changes resulting from renal impairment are: - Answer-increased phosphate
increased BUN
increased Scr
,Main intracellular cation that's normal range is 3.5-5mEq/L? - Answer-potassium
Elevate or reduce serum concentrations of potassium?
A. Corticosteroids
B. ACEi/ARBs/aliskerin
C. Canagliflozin
D. Albuterol
E. Loops
F. Insulin
G. Bactrim
H. Immunosuppressives (cyclosporine/ tacrolimus) - Answer-A. lower
B. elevate
C. elevate
D. lower
E. lower
F. lower
G. elevate
H. elevate
Medications that reduce extracellular sodium concentrations (normal 135-145mEq/L) - Answer-
carbamazepine, oxcarbazepine, SSRIs, diuretics
How does a salicylate overdose affect the body's acid-base balance? - Answer-body enters alkalosis
When the anion gap is elevated above 5-12 normal range, what is the body's metabolic state? - Answer-
metabolic acidosis
, A 4 year old gets a new prescription for an antibiotic and her mother is asking you if it's appropriately
dosed. What references could you refer to check? - Answer-Harriet Lane Handbook
Red Book by AAP
You get a call from a Dr. about to discharge a patient from the hospital who just had a GI ulcer bleed.
The doctor is asking what formulations are available for this patient's maintenance medications because
he is afraid oral tablets will be too harsh. What references do you check? - Answer-Package inserts
Any drug monograph - Lexi, Micromedex, ClinPharm, Facts and Comparisons
A very concerned father rushes into your pharmacy after finding a small white pill on his daughter's
bedroom floor. He asks you to identify the medication. How would you go about doing this if you didn't
recognize the tablet? - Answer-Use the Drug ID tool on Micromedex, Lexicomp, Pillbox, Ident-A-Drug
**only source without pill ID = AHFS
Which of the following are included in the package insert?
A. Indications
B. Black box warnings
C. Drug cost
D. Major changes in safety
E. Dosing administration
F. Drug strengths and formulations
G. ADRs and DDIs
H. Mechanism of Action
I. Contraindications
