Endocrine function - regulate cellular & organ function throughout life
- maintain homeostasis
Neurocrine - hormones secreted from nerve terminal
- lack endocrine gland
Paracrine - hormone released by cell acts upon cells nearby
Autocrine - cell releases hormone that acts upon itself
Hypothalamus hormones - releasing & inhibiting hormones
Pituitary hormones - ACTH
- TSH
- GH
- LH
- FSH
- PRL
- SST
- AVP
- OT
Thyroid hormones - T3
- T4
- CT
Parathyroid hormones - PTH
Adrenal hormones - ALDO
- CORT
- Epi
, - NE
Pancreatic hormones - Insulin
- glucagon
Ovarian hormones -E
-P
- Inhibin
Testiuclar hormones - T
- Inhibin
Hormone classes - protein/peptide - largest group - 3-200 amino acids
- steroids & steroid like
- tyrosine-derived hormones
Peptide hormones - mostly made intracellularly
- stored in secretory granules
- Ca2+ induced release
- hydrophillic - usually circulate in free form
- short half life
- bind to membrane receptors
- ANGII extracellularly synthesized from precursors in blood
Steroids & steroid-like hormones - "cholesterol" hormones
- intracellularly synthesized
- not stored in vesicles
- released by diffusion
- hydrophobic - bound to plasma protein in blood leading to longer half-life
- intracellular receptors
Tyrosine-derived hormones - made in adrenal medulla or thyroid
- catecholamines & T3/T