PHCH 667 final set with Questions and
correct Answers
The inulin clearance rate is equal to the GFR, because inulin is completely filtered through the
glomerulus and not metabolized, not secreted, and not re-absorbed at kidney tubules.
A. True
B. False - correct answer-✅A. True
Which drug can turn urine into red or orange color?
A. Doxorubicin
B. Amitriptyline
C. Atorvastatin
D. Chloroquine - correct answer-✅A. Doxorubicin
Creatinine Clearance is inversely related to the serum creatinine concentration.
A. True
B. False - correct answer-✅A. True
***urine creatinine concentration IS proportional to clearance***
Which of the following would elevate serum creatinine concentrations?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. all are correct
D. Urinary tract obstruction - correct answer-✅C. all are correct
which of the following is NOT true about kidney glomerulus?
A. protein biological (e.g. monoclonal antibodies) are filtered at glomerulus
B. most small molecule drugs are filtered at glomerulus, except for drugs bound to protein
plasma
C. GFR reflects kidney function and disease
D. filter substrates with moelcules weight <40,000 Da - correct answer-✅A. protein biological
(mAbs) are filtered at glomerulus
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost
completely filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed by
kidney tubules
A. True
B. False - correct answer-✅A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as
creatinine phosphate. creatinine is produced by cyclist ion of creatinine and then escapes
muscle cell membrane into the blood
, D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method - correct
answer-✅B. increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial infection.
imipenem Overdose can cause seizure and other CNS adverse effects, especially in patients
with CNS disorders and/or compromised renal function. imipenem dosage needs to be adjusted
based on calculated CrCl or GFR. Which formula would be most appropriate in this case to
calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation - correct answer-✅A. schwartz formula or counahan-baratt formula
drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to
an elevated serum creatinine concentration without any damage to renal function. these drugs
include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine - correct answer-✅A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances except for..
A. glucose
b. protein
c. sodium and potassium
d. albumin and hemoglobin - correct answer-✅c. sodium and potassium
which of the following methods/assays is NOT used to determine creatinine serum
concentration?
A. immunoassay (detect using antibodies against creatinine)
B. Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex)
C. enzymatic assay (reaction of creatinine with creatinine iminohydrolase) - correct answer-✅A.
immunoassay (detect using antibodies against creatinine)
which of the following would elevate serum creatinine concentration?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. urinary tract obstruction
D. low calorie diet
E. a,b, and c
F. b, c and d - correct answer-✅E. A, b, and c
-- protein rich (low calorie) diet would elevate BUN (not creatinine)
BUN:SCr ratio can be used to determine the cause of acute kidney injury as prerenal or
intrarenal cause. which of the following lab results suggest intrinsic renal damage?
A. BUN:SCr <10 and both BUN and SCr are elevated than normal
correct Answers
The inulin clearance rate is equal to the GFR, because inulin is completely filtered through the
glomerulus and not metabolized, not secreted, and not re-absorbed at kidney tubules.
A. True
B. False - correct answer-✅A. True
Which drug can turn urine into red or orange color?
A. Doxorubicin
B. Amitriptyline
C. Atorvastatin
D. Chloroquine - correct answer-✅A. Doxorubicin
Creatinine Clearance is inversely related to the serum creatinine concentration.
A. True
B. False - correct answer-✅A. True
***urine creatinine concentration IS proportional to clearance***
Which of the following would elevate serum creatinine concentrations?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. all are correct
D. Urinary tract obstruction - correct answer-✅C. all are correct
which of the following is NOT true about kidney glomerulus?
A. protein biological (e.g. monoclonal antibodies) are filtered at glomerulus
B. most small molecule drugs are filtered at glomerulus, except for drugs bound to protein
plasma
C. GFR reflects kidney function and disease
D. filter substrates with moelcules weight <40,000 Da - correct answer-✅A. protein biological
(mAbs) are filtered at glomerulus
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost
completely filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed by
kidney tubules
A. True
B. False - correct answer-✅A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as
creatinine phosphate. creatinine is produced by cyclist ion of creatinine and then escapes
muscle cell membrane into the blood
, D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method - correct
answer-✅B. increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial infection.
imipenem Overdose can cause seizure and other CNS adverse effects, especially in patients
with CNS disorders and/or compromised renal function. imipenem dosage needs to be adjusted
based on calculated CrCl or GFR. Which formula would be most appropriate in this case to
calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation - correct answer-✅A. schwartz formula or counahan-baratt formula
drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to
an elevated serum creatinine concentration without any damage to renal function. these drugs
include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine - correct answer-✅A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances except for..
A. glucose
b. protein
c. sodium and potassium
d. albumin and hemoglobin - correct answer-✅c. sodium and potassium
which of the following methods/assays is NOT used to determine creatinine serum
concentration?
A. immunoassay (detect using antibodies against creatinine)
B. Jaffe reaction (reaction of creatinine with picric acid to form a red-orange complex)
C. enzymatic assay (reaction of creatinine with creatinine iminohydrolase) - correct answer-✅A.
immunoassay (detect using antibodies against creatinine)
which of the following would elevate serum creatinine concentration?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. urinary tract obstruction
D. low calorie diet
E. a,b, and c
F. b, c and d - correct answer-✅E. A, b, and c
-- protein rich (low calorie) diet would elevate BUN (not creatinine)
BUN:SCr ratio can be used to determine the cause of acute kidney injury as prerenal or
intrarenal cause. which of the following lab results suggest intrinsic renal damage?
A. BUN:SCr <10 and both BUN and SCr are elevated than normal
