MLS 2210 Exam 3 (347 questions) with verified solutions

MLS 2210 Exam 3 (347 questions) with
verified solutions

How many antigens are in the Kell blood group system? - correct answer
n n n n n n n n n n n n n


✔36


What are the Kell blood group antigens that we are focusing on? - correct
n n n n n n n n n n n n n n


answer ✔K n




k n




Kpa
Kpb
K0
Ku
Jsa
Jsb


K antigen inheritance in Caucasians is - correct answer ✔9%
n n n n n n n n n




How early can the K antigen be detected on fetal RBCs? When is it well
n n n n n n n n n n n n n n n


developed? - correct answer ✔as early as 10 weeks
n n n n n n n n




At birthn




Can HDFN occur because of the K antigen? Why? - correct answer ✔Yes - it's
n n n n n n n n n n n n n n


nhighly expressed on fetal RBC cells and 𝐩𝐫𝐞𝐜𝐮𝐫𝐬𝐨𝐫𝐬
n n n n n n n

,maternal antibodies react with the fetal cells which will be severe and fatal
n n n n n n n n n n n n




K antigens have relatively _____ antigen sites, but are ______. - correct
n n n n n n n n n n n n


answer ✔low, highly immunogenic
n n n




Why don't Kell antibodies activate the complement? - correct answer ✔They
n n n n n n n n n n n


are primarily IgG. They need to activate two globular heads, but they are
n n n n n n n n n n n n n


too far apart due to the low amount of antigen sites
n n n n n n n n n n




Since Kell antibodies do not bind complement, where do HTR occur? -
n n n n n n n n n n n n


correct answer ✔extravascular
n n




What is the third most commonly encountered alloantibody in the U.S.? -
n n n n n n n n n n n n


correct answer ✔Anti-K n n




If a K negative patient was transfused with K positive blood, what is the
n n n n n n n n n n n n n n


chance that they will develop anti-K antibodies? - correct answer ✔10%
n n n n n n n n n n




Anti-K is primarily what Ig?
n n n n




Is it capable of HDFN and HTR? - correct answer ✔IgG
n n n n n n n n n n




Yes


What is the best method to detect Anti-K? - correct answer ✔IAT
n n n n n n n n n n n




Non-RBC immune IgM anti-K is rare and has been associated with - correct
n n n n n n n n n n n n n


answer ✔Bacterial infections of
n n n n

,Mycobacteria
E. coli
n




E. faecalis
n




M. morganii
n




C. jejuni
n




etc.


Some anti-K will react poorly in this media.
n n n n n n n




Although anti-K is primarily IgG, some can agglutinate at what temperature?
n n n n n n n n n n n


- correct answer ✔LISS
n n n




Room temperature in saline
n n n




Remember that IgG likes warm temps
n n n n n




Non-RBC Immune - correct answer ✔does NOT need RBC exposure
n n n n n n n n n




What effect do routine blood bank enzymes (ficin and papain) have on Kell
n n n n n n n n n n n n n


antigens? - correct answer ✔They have no effect on them
n n n n n n n n n




What effect does DTT have on Kell antigens? - correct answer ✔It can
n n n n n n n n n n n n n


destroy them n




What percent of Africans inherit k? - correct answer ✔100%
n n n n n n n n n




What percent of caucasians inherit k? - correct answer ✔98.8%
n n n n n n n n n

, Anti-k antibody is ____. So it is _______ to find k antigen negative blood -
n n n n n n n n n n n n n n n


correct answer ✔rare n n




difficult


What chromosome is the KEL gene found on? - correct answer ✔7
n n n n n n n n n n n




What is responsible for the different Kell antigens? - correct answer ✔Single
n n n n n n n n n n n n


base mutations encoding amino acid substitutions
n n n n n




What is responsible for K0 (Kell null phenotype) - correct answer ✔A rare
n n n n n n n n n n n n n


silent allele at the KEL locus
n n n n n




Occurs when a person inherits two K0 genes
n n n n n n n




K0 is considered to be ____ at 1:25,000 in _____ - correct answer ✔rare
n n n n n n n n n n n n n n




Caucasians


Immunized individuals with K0 typically make an antibody called - correct
n n n n n n n n n n n


answer ✔anti-Ku (K5) n n




anti-Ku (K5) recognizes this antigen - correct answer ✔universal "total-Kell"
n n n n n n n n n




universal "total-Kell" is present on - correct answer ✔all cells except for K0
n n n n n n n n n n n n




Is anti-Ku (K5) capable of causing HTR and HDFN? - correct answer ✔Yes, so
n n n n n n n n n n n n n n


they are considered to be clinically significant
n n n n n n