, Rubin's Pathology: Clinicopathologic Foundations of Medicine Testba
Q Q Q Q Q Q
nk/Studyguide
Chapter 1: Cell Adaptation, Injury and Death
Q Q Q Q Q Q
Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a result o
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
1. f:
A) release of stored calcium from the mitochondria.
Q Q Q Q Q Q
B) improved intracellular volume regulation.
Q Q Q
C) decreased influx across the cell membrane.
Q Q Q Q Q
D) attraction of calcium to fatty infiltrates.
Q Q Q Q Q
The patient is found to have liver disease, resulting in the removal of a lobe of his liver. Ada
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
2. ptation to the reduced size of the liver leads to
Q Q Q of the remaining liver cells.
Q Q Q Q Q Q Q Q Q Q Q
A) metaplasia
B) organ atrophy Q
C) compensatory hyperplasia Q
D) physiologic hypertrophy Q
A person eating peanuts starts choking and collapses. His airway obstruction is partially
Q Q Q Q Q Q Q Q Q Q Q Q Q
cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hypoxia
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
3. caused a cerebral infarction and resulting
Q Q in the brain.
Q Q Q Q Q Q
A) caspase activation Q
B) coagulation necrosis Q
C) rapid phagocytosis Q
D) protein p53 deficiency Q Q
Bacteria and viruses cause cell damage by
Q Q Q Q Q Q Q
4. , which is unique from the intracellular Q Q Q Q Q Q
Q damage caused by other injurious agents.
Q Q Q Q Q
A) disrupting the sodium/potassium ATPase pump Q Q Q Q
B) interrupting oxidative metabolism processes Q Q Q
C) replicating and producing continued injury Q Q Q Q
D) decreasing protein synthesis and function Q Q Q Q
The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hypoxi
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
5. c cell injury and the release of free radicals. Free radicals damage cells by:
Q Q Q Q Q Q Q Q Q Q Q Q Q
A) destroying phospholipids in the cell membrane.
Q Q Q Q Q
B) altering the immune response of the cell.
Q Q Q Q Q Q
C) disrupting calcium storage in the cell. Q Q Q Q Q
,D) inactivation of enzymes and mitochondria. Q Q Q Q
6. Injured cells have impaired flow of substances through the cell membrane as a result of:
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
A) increased fat load. Q Q
B) altered permeability. Q
C) altered glucose utilization.Q Q
D) increased surface receptors. Q Q
7. Reversible adaptive intracellular responses are initiated by:
Q Q Q Q Q Q
A) stimulus overload. Q
B) genetic mutations. Q
C) chemical messengers. Q
D) mitochondrial DNA. Q
8. Injured cells become very swollen as a result of:
Q Q Q Q Q Q Q Q
A) increased cell protein synthesis. Q Q Q
B) altered cell volume regulation.
Q Q Q
C) passive entry of potassium into the cell.
Q Q Q Q Q Q
D) bleb formation in the plasma membrane.
Q Q Q Q Q
A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps on
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The necrotic c
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
9. ell death is characterized by:
Q Q Q Q
A) rapid apoptosis. Q
B) cellular rupture. Q
C) shrinkage and collapse. Q Q
D) chronic inflammation. Q
A 99-year-
Q
10. old woman has experienced the decline of cell function associated with age. A group of theori
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
es of cellular aging focus on programmed:
Q Q Q Q Q Q
A) changes with genetic influences. Q Q Q
B) elimination of cell receptor sites. Q Q Q Q
C) insufficient telomerase enzyme. Q Q
D) DNA mutation or faulty repair.
Q Q Q Q
An 89-year- Q
old female patient has experienced significant decreases in her mobility and stamina during a
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
3-
11. week hospital stay for the treatment of a femoral head fracture. Which of the following pheno
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
mena most likely accounts for the patients decrease in muscle function
Q Q Q Q Q Q Q Q Q Q
that underlies her reduced mobility?
Q Q Q Q
, A) Impaired muscle cell metabolism resulting from metaplasia
Q Q Q Q Q Q
B) Dysplasia as a consequence of inflammation during bone remodeling
Q Q Q Q Q Q Q Q
C) Disuse atrophy of muscle cells during a prolonged period of immobility
Q Q Q Q Q Q Q Q Q Q
D) Ischemic atrophy resulting from vascular changes while on bedrest
Q Q Q Q Q Q Q Q
A 20-year-
Q
old college student has presented to her campus medical clinic for a scheduled Papanicolaou (P
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
12. ap) smear. The clinician who will interpret the smear will examine cell samples for evidence o
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
f:
A) changes in cell shape, size, and organization.
Q Q Q Q Q Q
B) the presence of unexpected cell types.
Q Q Q Q Q
C) ischemic changes in cell samples. Q Q Q Q
D) abnormally high numbers of cells in a specified field. Q Q Q Q Q Q Q Q
Which of the following pathophysiologic processes is most likely to result in metastatic calcific
Q Q Q Q Q Q Q Q Q Q Q Q Q
13. on?
A) Benign prostatic hyperplasia Q Q
B) Liver cirrhosis Q
C) Impaired glycogen metabolism Q Q
D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology techni
Q Q Q Q Q Q Q Q Q Q Q Q Q
an is aware of the need to minimize her exposure to ionizing radiation. What is the primary ratio
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
14. ale for the technicians precautions?
Q Q Q Q
A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
Q Q Q Q Q Q
B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
Q Q Q Q Q Q Q Q Q Q Q
C) Radiation interferes with DNA synthesis and mitosis.
Q Q Q Q Q Q
D) Radiation decreases the action potential of rapidly dividing cells.
Q Q Q Q Q Q Q Q
The parents of a 4-year-
Q Q Q Q
old girl have sought care because their daughter has admitted to chewing and swallowing impo
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
15. rted toy figurines that have been determined to be made of lead. Which of the following blood
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
tests should the care team prioritize?
Q Q Q Q Q
A) White blood cell levels with differential
Q Q Q Q Q
B) Red blood cell levels and morphology
Q Q Q Q Q
C) Urea and creatinine levels
Q Q Q
D) Liver function panel Q Q
A 70-year-
Q
old male patient has been admitted to a hospital for the treatment of a recent hemorrhagic strok
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
16. hat has left him with numerous motor and sensory deficits. These deficits
Q Q Q Q Q Q Q Q Q Q Q
are most likely the result of which of the following mechanisms of cell injury?
Q Q Q Q Q Q Q Q Q Q Q Q Q
Q Q Q Q Q Q
nk/Studyguide
Chapter 1: Cell Adaptation, Injury and Death
Q Q Q Q Q Q
Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a result o
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
1. f:
A) release of stored calcium from the mitochondria.
Q Q Q Q Q Q
B) improved intracellular volume regulation.
Q Q Q
C) decreased influx across the cell membrane.
Q Q Q Q Q
D) attraction of calcium to fatty infiltrates.
Q Q Q Q Q
The patient is found to have liver disease, resulting in the removal of a lobe of his liver. Ada
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
2. ptation to the reduced size of the liver leads to
Q Q Q of the remaining liver cells.
Q Q Q Q Q Q Q Q Q Q Q
A) metaplasia
B) organ atrophy Q
C) compensatory hyperplasia Q
D) physiologic hypertrophy Q
A person eating peanuts starts choking and collapses. His airway obstruction is partially
Q Q Q Q Q Q Q Q Q Q Q Q Q
cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hypoxia
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
3. caused a cerebral infarction and resulting
Q Q in the brain.
Q Q Q Q Q Q
A) caspase activation Q
B) coagulation necrosis Q
C) rapid phagocytosis Q
D) protein p53 deficiency Q Q
Bacteria and viruses cause cell damage by
Q Q Q Q Q Q Q
4. , which is unique from the intracellular Q Q Q Q Q Q
Q damage caused by other injurious agents.
Q Q Q Q Q
A) disrupting the sodium/potassium ATPase pump Q Q Q Q
B) interrupting oxidative metabolism processes Q Q Q
C) replicating and producing continued injury Q Q Q Q
D) decreasing protein synthesis and function Q Q Q Q
The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hypoxi
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
5. c cell injury and the release of free radicals. Free radicals damage cells by:
Q Q Q Q Q Q Q Q Q Q Q Q Q
A) destroying phospholipids in the cell membrane.
Q Q Q Q Q
B) altering the immune response of the cell.
Q Q Q Q Q Q
C) disrupting calcium storage in the cell. Q Q Q Q Q
,D) inactivation of enzymes and mitochondria. Q Q Q Q
6. Injured cells have impaired flow of substances through the cell membrane as a result of:
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
A) increased fat load. Q Q
B) altered permeability. Q
C) altered glucose utilization.Q Q
D) increased surface receptors. Q Q
7. Reversible adaptive intracellular responses are initiated by:
Q Q Q Q Q Q
A) stimulus overload. Q
B) genetic mutations. Q
C) chemical messengers. Q
D) mitochondrial DNA. Q
8. Injured cells become very swollen as a result of:
Q Q Q Q Q Q Q Q
A) increased cell protein synthesis. Q Q Q
B) altered cell volume regulation.
Q Q Q
C) passive entry of potassium into the cell.
Q Q Q Q Q Q
D) bleb formation in the plasma membrane.
Q Q Q Q Q
A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps on
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The necrotic c
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
9. ell death is characterized by:
Q Q Q Q
A) rapid apoptosis. Q
B) cellular rupture. Q
C) shrinkage and collapse. Q Q
D) chronic inflammation. Q
A 99-year-
Q
10. old woman has experienced the decline of cell function associated with age. A group of theori
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
es of cellular aging focus on programmed:
Q Q Q Q Q Q
A) changes with genetic influences. Q Q Q
B) elimination of cell receptor sites. Q Q Q Q
C) insufficient telomerase enzyme. Q Q
D) DNA mutation or faulty repair.
Q Q Q Q
An 89-year- Q
old female patient has experienced significant decreases in her mobility and stamina during a
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
3-
11. week hospital stay for the treatment of a femoral head fracture. Which of the following pheno
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
mena most likely accounts for the patients decrease in muscle function
Q Q Q Q Q Q Q Q Q Q
that underlies her reduced mobility?
Q Q Q Q
, A) Impaired muscle cell metabolism resulting from metaplasia
Q Q Q Q Q Q
B) Dysplasia as a consequence of inflammation during bone remodeling
Q Q Q Q Q Q Q Q
C) Disuse atrophy of muscle cells during a prolonged period of immobility
Q Q Q Q Q Q Q Q Q Q
D) Ischemic atrophy resulting from vascular changes while on bedrest
Q Q Q Q Q Q Q Q
A 20-year-
Q
old college student has presented to her campus medical clinic for a scheduled Papanicolaou (P
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
12. ap) smear. The clinician who will interpret the smear will examine cell samples for evidence o
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
f:
A) changes in cell shape, size, and organization.
Q Q Q Q Q Q
B) the presence of unexpected cell types.
Q Q Q Q Q
C) ischemic changes in cell samples. Q Q Q Q
D) abnormally high numbers of cells in a specified field. Q Q Q Q Q Q Q Q
Which of the following pathophysiologic processes is most likely to result in metastatic calcific
Q Q Q Q Q Q Q Q Q Q Q Q Q
13. on?
A) Benign prostatic hyperplasia Q Q
B) Liver cirrhosis Q
C) Impaired glycogen metabolism Q Q
D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology techni
Q Q Q Q Q Q Q Q Q Q Q Q Q
an is aware of the need to minimize her exposure to ionizing radiation. What is the primary ratio
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
14. ale for the technicians precautions?
Q Q Q Q
A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
Q Q Q Q Q Q
B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
Q Q Q Q Q Q Q Q Q Q Q
C) Radiation interferes with DNA synthesis and mitosis.
Q Q Q Q Q Q
D) Radiation decreases the action potential of rapidly dividing cells.
Q Q Q Q Q Q Q Q
The parents of a 4-year-
Q Q Q Q
old girl have sought care because their daughter has admitted to chewing and swallowing impo
Q Q Q Q Q Q Q Q Q Q Q Q Q Q
15. rted toy figurines that have been determined to be made of lead. Which of the following blood
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
tests should the care team prioritize?
Q Q Q Q Q
A) White blood cell levels with differential
Q Q Q Q Q
B) Red blood cell levels and morphology
Q Q Q Q Q
C) Urea and creatinine levels
Q Q Q
D) Liver function panel Q Q
A 70-year-
Q
old male patient has been admitted to a hospital for the treatment of a recent hemorrhagic strok
Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q
16. hat has left him with numerous motor and sensory deficits. These deficits
Q Q Q Q Q Q Q Q Q Q Q
are most likely the result of which of the following mechanisms of cell injury?
Q Q Q Q Q Q Q Q Q Q Q Q Q
